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1) Multiscale representation of genomic signals (Nature Methods) Sunday April 13th 2014
Theo A Knijnenburg, Stephen A Ramsey, Benjamin P Berman, Kathleen A Kennedy, Arian F A Smit, Lodewyk F A Wessels, Peter W Laird, Alan Aderem, Ilya Shmulevich

2) Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos (Nature Methods) Sunday April 13th 2014
Fran, William M McFadden, Baixue Yao, Edwin M Munro

3) Rapid adaptive optical recovery of optimal resolution over large volumes (Nature Methods) Sunday April 13th 2014
Kai Wang, Daniel E Milkie, Ankur Saxena, Peter Engerer, Thomas Misgeld, Marianne E Bronner, Jeff Mumm, Eric Betzig

4) Fluorescence nanoscopy by polarization modulation and polarization angle narrowing (Nature Methods) Sunday April 6th 2014
Nour Hafi, Matthias Grunwald, Laura S van den Heuvel, Timo Aspelmeier, Jian-Hua Chen, Marta Zagrebelsky, Ole M Sch, Claudia Steinem, Martin Korte, Axel Munk, Peter J Walla

5) Light-sheet microscopy using an Airy beam (Nature Methods) Sunday April 6th 2014
Tom Vettenburg, Heather I C Dalgarno, Jonathan Nylk, Clara Coll-Llad, David E K Ferrier, Tom, Frank J Gunn-Moore, Kishan Dholakia

6) Measuring similarity between dynamic ensembles of biomolecules (Nature Methods) Sunday April 6th 2014
Shan Yang, Lo, Hashim M Al-Hashimi

7) Quantifying Drosophila food intake: comparative analysis of current methodology (Nature Methods) Sunday March 30th 2014
Sonali A Deshpande, Gil B Carvalho, Ariadna Amador, Angela M Phillips, Sany Hoxha, Keith J Lizotte, William W Ja

8) Transcriptional profiling of cells sorted by RNA abundance (Nature Methods) Sunday March 30th 2014
Sandy Klemm, Stefan Semrau, Kay Wiebrands, Dylan Mooijman, Dina A Faddah, Rudolf Jaenisch, Alexander van Oudenaarden

9) Function-based identification of mammalian enhancers using site-specific integration (Nature Methods) Sunday March 23rd 2014
Diane E Dickel, Yiwen Zhu, Alex S Nord, John N Wylie, Jennifer A Akiyama, Veena Afzal, Ingrid Plajzer-Frick, Aileen Kirkpatrick, Berthold G, Benoit G Bruneau, Axel Visel, Len A Pennacchio

10) FIREWACh: high-throughput functional detection of transcriptional regulatory modules in mammalian cells (Nature Methods) Sunday March 23rd 2014
Matthew Murtha, Zeynep Tokcaer-Keskin, Zuojian Tang, Francesco Strino, Xi Chen, Yatong Wang, Xiangmei Xi, Claudio Basilico, Stuart Brown, Richard Bonneau, Yuval Kluger, Lisa Dailey

11) The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells (Nature Methods) Sunday March 23rd 2014
Julia Petschnigg, Bella Groisman, Max Kotlyar, Mikko Taipale, Yong Zheng, Christoph F Kurat, Azin Sayad, J Rafael Sierra, Mojca Mattiazzi Usaj, Jamie Snider, Alex Nachman, Irina Krykbaeva, Ming-Sound Tsao, Jason Moffat, Tony Pawson, Susan Lindquist, Igor Jurisica, Igor Stagljar

12) Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon (Nature Methods) Monday March 17th 2014
Christian Fr, M Wayne Davis, Mihail Sarov, Jon Taylor, Stephane Flibotte, Matthew LaBella, Andrei Pozniakovski, Donald G Moerman, Erik M Jorgensen

13) Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein (Nature Methods) Monday March 17th 2014
Jun Chu, Russell D Haynes, St, Pengpeng Li, Emilio Gonz, John S Burg, Niloufar J Ataie, Amy J Lam, Paula J Cranfill, Michelle A Baird, Michael W Davidson, Ho-Leung Ng, K Christopher Garcia, Christopher H Contag, Kang Shen, Helen M Blau, Michael Z Lin

14) Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers (Nature Methods) Monday March 17th 2014
Johan Hattne, Nathaniel Echols, Rosalie Tran, Jan Kern, Richard J Gildea, Aaron S Brewster, Roberto Alonso-Mori, Carina Gl, Julia Hellmich, Hartawan Laksmono, Raymond G Sierra, Benedikt Lassalle-Kaiser, Alyssa Lampe, Guangye Han, Sheraz Gul, D, Despina Milathianaki, Alan R Fry, Alan Miahnahri, William E White, Donald W Schafer, M Marvin Seibert, Jason E Koglin, Dimosthenis Sokaras, Tsu-Chien Weng, Jonas Sellberg, Matthew J Latimer, Pieter Glatzel, Petrus H Zwart, Ralf W Grosse-Kunstleve, Michael J Bogan, Marc Messerschmidt, Garth J Williams, S, Johannes Messinger, Athina Zouni, Junko Yano, Uwe Bergmann, Vittal K Yachandra, Paul D Adams, Nicholas K Sauter

15) PyClone: statistical inference of clonal population structure in cancer (Nature Methods) Monday March 17th 2014
Andrew Roth, Jaswinder Khattra, Damian Yap, Adrian Wan, Emma Laks, Justina Biele, Gavin Ha, Samuel Aparicio, Alexandre Bouchard-C, Sohrab P Shah

16) Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals (Nature Methods) Sunday March 9th 2014
Evan J Olson, Lucas A Hartsough, Brian P Landry, Raghav Shroff, Jeffrey J Tabor

17) Dynamic characterization of growth and gene expression using high-throughput automated flow cytometry (Nature Methods) Sunday March 9th 2014
Ignacio A Zuleta, Andr, Hao Li, Hana El-Samad

18) Single-molecule motions enable direct visualization of biomolecular interactions in solution (Nature Methods) Sunday March 9th 2014
Quan Wang, W E Moerner

19) Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry (Nature Methods) Sunday March 2nd 2014
Charlotte Giesen, Hao A O Wang, Denis Schapiro, Nevena Zivanovic, Andrea Jacobs, Bodo Hattendorf, Peter J Sch, Daniel Grolimund, Joachim M Buhmann, Simone Brandt, Zsuzsanna Varga, Peter J Wild, Detlef G, Bernd Bodenmiller

20) Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects (Nature Methods) Sunday March 2nd 2014
Bin Shen, Wensheng Zhang, Jun Zhang, Jiankui Zhou, Jianying Wang, Li Chen, Lu Wang, Alex Hodgkins, Vivek Iyer, Xingxu Huang, William C Skarnes

21) Structure determination of noncanonical RNA motifs guided by 1H NMR chemical shifts (Nature Methods) Sunday March 2nd 2014
Parin Sripakdeevong, Mirko Cevec, Andrew T Chang, Mich, Melanie Ziegeler, Qin Zhao, George E Fox, Xiaolian Gao, Scott D Kennedy, Ryszard Kierzek, Edward P Nikonowicz, Harald Schwalbe, Roland K O Sigel, Douglas H Turner, Rhiju Das

22) Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering (Nature Methods) Sunday March 2nd 2014
Lu Wei, Fanghao Hu, Yihui Shen, Zhixing Chen, Yong Yu, Chih-Chun Lin, Meng C Wang, Wei Min

23) Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods (Nature Methods) Sunday February 23rd 2014
Simon C Warby, Sabrina L Wendt, Peter Welinder, Emil G S Munk, Oscar Carrillo, Helge B D Sorensen, Poul Jennum, Paul E Peppard, Pietro Perona, Emmanuel Mignot

24) Gold rotor bead tracking for high-speed measurements of DNA twist, torque and extension (Nature Methods) Sunday February 23rd 2014
Paul Lebel, Aakash Basu, Florian C Oberstrass, Elsa M Tretter, Zev Bryant

25) Identification of small molecules that support human leukemia stem cell activity ex vivo (Nature Methods) Sunday February 23rd 2014
Caroline Pabst, Jana Krosl, Iman Fares, Genevi, R, Anne Marinier, S, Jos, Guy Sauvageau

26) Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity (Nature Methods) Sunday February 16th 2014
John P Guilinger, Vikram Pattanayak, Deepak Reyon, Shengdar Q Tsai, Jeffry D Sander, J Keith Joung, David R Liu

27) Cryo-scanning transmission electron tomography of vitrified cells (Nature Methods) Sunday February 16th 2014
Sharon Grayer Wolf, Lothar Houben, Michael Elbaum

28) Efficient multivariate linear mixed model algorithms for genome-wide association studies (Nature Methods) Sunday February 16th 2014
Xiang Zhou, Matthew Stephens

29) Independent optical excitation of distinct neural populations (Nature Methods) Sunday February 9th 2014
Nathan C Klapoetke, Yasunobu Murata, Sung Soo Kim, Stefan R Pulver, Amanda Birdsey-Benson, Yong Ku Cho, Tania K Morimoto, Amy S Chuong, Eric J Carpenter, Zhijian Tian, Jun Wang, Yinlong Xie, Zhixiang Yan, Yong Zhang, Brian Y Chow, Barbara Surek, Michael Melkonian, Vivek Jayaraman, Martha Constantine-Paton, Gane Ka-Shu Wong, Edward S Boyden

30) A synthetic luciferin improves bioluminescence imaging in live mice (Nature Methods) Sunday February 9th 2014
Melanie S Evans, Joanna P Chaurette, Spencer T Adams, Gadarla R Reddy, Miranwda A Paley, Neil Aronin, Jennifer A Prescher, Stephen C Miller

31) Isolation of single-base genome-edited human iPS cells without antibiotic selection (Nature Methods) Sunday February 9th 2014
Yuichiro Miyaoka, Amanda H Chan, Luke M Judge, Jennie Yoo, Miller Huang, Trieu D Nguyen, Paweena P Lizarraga, Po-Lin So, Bruce R Conklin

32) A mass spectrometry (Nature Methods) Sunday February 9th 2014
Argyris Politis, Florian Stengel, Zoe Hall, Helena Hern, Alexander Leitner, Thomas Walzthoeni, Carol V Robinson, Ruedi Aebersold

33) Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT (Nature Methods) Sunday February 2nd 2014
Ralf Jungmann, Maier S Avenda, Johannes B Woehrstein, Mingjie Dai, William M Shih, Peng Yin

34) Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells (Nature Methods) Sunday February 2nd 2014
Nils A Kulak, Garwin Pichler, Igor Paron, Nagarjuna Nagaraj, Matthias Mann

35) Functional annotation of noncoding sequence variants (Nature Methods) Sunday February 2nd 2014
Graham R S Ritchie, Ian Dunham, Eleftheria Zeggini, Paul Flicek

36) Similarity network fusion for aggregating data types on a genomic scale (Nature Methods) Sunday January 26th 2014
Bo Wang, Aziz M Mezlini, Feyyaz Demir, Marc Fiume, Zhuowen Tu, Michael Brudno, Benjamin Haibe-Kains, Anna Goldenberg

37) Correlative super-resolution fluorescence and metal-replica transmission electron microscopy (Nature Methods) Sunday January 26th 2014
Kem A Sochacki, Gleb Shtengel, Schuyler B van Engelenburg, Harald F Hess, Justin W Taraska

38) Epigenome-wide association studies without the need for cell-type composition (Nature Methods) Sunday January 26th 2014
James Zou, Christoph Lippert, David Heckerman, Martin Aryee, Jennifer Listgarten

39) Objective comparison of particle tracking methods (Nature Methods) Sunday January 19th 2014
Nicolas Chenouard, Ihor Smal, Fabrice de Chaumont, Martin Ma, Ivo F Sbalzarini, Yuanhao Gong, Janick Cardinale, Craig Carthel, Stefano Coraluppi, Mark Winter, Andrew R Cohen, William J Godinez, Karl Rohr, Yannis Kalaidzidis, Liang Liang, James Duncan, Hongying Shen, Yingke Xu, Klas E G Magnusson, Joakim Jald, Helen M Blau, Perrine Paul-Gilloteaux, Philippe Roudot, Charles Kervrann, Fran, Jean-Yves Tinevez, Spencer L Shorte, Joost Willemse, Katherine Celler, Gilles P van Wezel, Han-Wei Dan, Yuh-Show Tsai, Carlos Ortiz de Sol, Jean-Christophe Olivo-Marin, Erik Meijering

40) Targeted protein quantification using sparse reference labeling (Nature Methods) Sunday January 19th 2014
Ching-Yun Chang, Eduard Sabid, Ruedi Aebersold, Olga Vitek

41) Continuous throughput and long-term observation of single-molecule FRET without immobilization (Nature Methods) Sunday January 19th 2014
Swati Tyagi, Virginia VanDelinder, Niccol, Gustavo Fuertes, Sigrid Milles, Morgane Agez, Edward A Lemke

42) Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue (Nature Methods) Monday January 13th 2014
Ditte Lovatt, Brittani K Ruble, Jaehee Lee, Hannah Dueck, Tae Kyung Kim, Stephen Fisher, Chantal Francis, Jennifer M Spaethling, John A Wolf, M Sean Grady, Alexandra V Ulyanova, Sean B Yeldell, Julianne C Griepenburg, Peter T Buckley, Junhyong Kim, Jai-Yoon Sul, Ivan J Dmochowski, James Eberwine

43) Scalable inference of heterogeneous reaction kinetics from pooled single-cell recordings (Nature Methods) Monday January 13th 2014
Christoph Zechner, Michael Unger, Serge Pelet, Matthias Peter, Heinz Koeppl

44) EC-BLAST: a tool to automatically search and compare enzyme reactions (Nature Methods) Monday January 13th 2014
Syed Asad Rahman, Sergio Martinez Cuesta, Nicholas Furnham, Gemma L Holliday, Janet M Thornton

45) Single-molecule evaluation of fluorescent protein photoactivation efficiency using an in vivo nanotemplate (Nature Methods) Sunday January 5th 2014
Nela Durisic, Lara Laparra-Cuervo, Ángel Sandoval-Álvarez, Joseph Steven Borbely, Melike Lakadamyali

46) Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes (Nature Methods) Sunday January 5th 2014
Thomas Thestrup, Julia Litzlbauer, Ingo Bartholom, Marsilius Mues, Luigi Russo, Hod Dana, Yuri Kovalchuk, Yajie Liang, Georgios Kalamakis, Yvonne Laukat, Stefan Becker, Gregor Witte, Anselm Geiger, Taylor Allen, Lawrence C Rome, Tsai-Wen Chen, Douglas S Kim, Olga Garaschuk, Christian Griesinger, Oliver Griesbeck

47) Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship (Nature Methods) Sunday December 22nd 2013
Hidehiko K Inagaki, Yonil Jung, Eric D Hoopfer, Allan M Wong, Neeli Mishra, John Y Lin, Roger Y Tsien, David J Anderson

48) Quantitative single-cell RNA-seq with unique molecular identifiers (Nature Methods) Sunday December 22nd 2013
Saiful Islam, Amit Zeisel, Simon Joost, Gioele La Manno, Pawel Zajac, Maria Kasper, Peter L, Sten Linnarsson

49) High-resolution mapping of transcription factor binding sites on native chromatin (Nature Methods) Sunday December 15th 2013
Sivakanthan Kasinathan, Guillermo A Orsi, Gabriel E Zentner, Kami Ahmad, Steven Henikoff

50) Drift time-specific collision energies enable deep-coverage data- independent acquisition proteomics (Nature Methods) Sunday December 15th 2013
Ute Distler, J, Pedro Navarro, Yishai Levin, Hansj, Stefan Tenzer

51) Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins (Nature Methods) Monday December 9th 2013
Jacob J Kennedy, Susan E Abbatiello, Kyunggon Kim, Ping Yan, Jeffrey R Whiteaker, Chenwei Lin, Jun Seok Kim, Yuzheng Zhang, Xianlong Wang, Richard G Ivey, Lei Zhao, Hophil Min, Youngju Lee, Myeong-Hee Yu, Eun Gyeong Yang, Cheolju Lee, Pei Wang, Henry Rodriguez, Youngsoo Kim, Steven A Carr, Amanda G Paulovich

52) A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles (Nature Methods) Sunday December 1st 2013
Chu Wang, Eranthie Weerapana, Megan M Blewett, Benjamin F Cravatt

53) Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny (Nature Methods) Sunday December 1st 2013
Xiaolei Yin, Henner F Farin, Johan H van Es, Hans Clevers, Robert Langer, Jeffrey M Karp

54) A quantitative liposome microarray to systematically characterize protein-lipid interactions (Nature Methods) Sunday November 24th 2013
Antoine-Emmanuel Saliba, Ivana Vonkova, Stefano Ceschia, Greg M Findlay, Kenji Maeda, Christian Tischer, Samy Deghou, Vera van Noort, Peer Bork, Tony Pawson, Jan Ellenberg, Anne-Claude Gavin

55) Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing (Nature Methods) Sunday November 24th 2013
Rui Zhang, Xin Li, Gokul Ramaswami, Kevin S Smith, Gustavo Turecki, Stephen B Montgomery, Jin Billy Li

56) A holidic medium for Drosophila melanogaster (Nature Methods) Sunday November 17th 2013
Matthew D W Piper, Eric Blanc, Ricardo Leit, Mingyao Yang, Xiaoli He, Nancy J Linford, Matthew P Hoddinott, Corinna Hopfen, George A Soultoukis, Christine Niemeyer, Fiona Kerr, Scott D Pletcher, Carlos Ribeiro, Linda Partridge

57) Integrating protein-protein interaction networks with phenotypes reveals signs of interactions (Nature Methods) Sunday November 17th 2013
Arunachalam Vinayagam, Jonathan Zirin, Charles Roesel, Yanhui Hu, Bahar Yilmazel, Anastasia A Samsonova, Ralph A Neum, Stephanie E Mohr, Norbert Perrimon

58) HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics (Nature Methods) Sunday November 17th 2013
Rui M M Branca, Lukas M Orre, Henrik J Johansson, Viktor Granholm, Mikael Huss, Åsa Pérez-Bercoff, Jenny Forshed, Lukas K, Janne Lehti

59) Deciphering laminar-specific neural inputs with line-scanning fMRI (Nature Methods) Sunday November 17th 2013
Xin Yu, Chunqi Qian, Der-yow Chen, Stephen J Dodd, Alan P Koretsky

60) Parallel measurement of dynamic changes in translation rates in single cells (Nature Methods) Sunday November 10th 2013
Kyuho Han, Ariel Jaimovich, Gautam Dey, Davide Ruggero, Oded Meyuhas, Nahum Sonenberg, Tobias Meyer

61) Quantifying the local resolution of cryo-EM density maps (Nature Methods) Sunday November 10th 2013
Alp Kucukelbir, Fred J Sigworth, Hemant D Tagare

62) Systematic evaluation of spliced alignment programs for RNA-seq data (Nature Methods) Sunday November 3rd 2013
P, Tamara Steijger, Botond Sipos, Gregory R Grant, Andr, Gunnar R, Nick Goldman, Tim J Hubbard, Jennifer Harrow, Roderic Guig, Paul Bertone

63) Assessment of transcript reconstruction methods for RNA-seq (Nature Methods) Sunday November 3rd 2013
Tamara Steijger, Josep F Abril, P, Felix Kokocinski, Tim J Hubbard, Roderic Guig, Jennifer Harrow, Paul Bertone

64) Coupling transcription factor occupancy to nucleosome architecture with DNase-FLASH (Nature Methods) Sunday November 3rd 2013
Jeff Vierstra, Hao Wang, Sam John, Richard Sandstrom, John A Stamatoyannopoulos

65) Accelerated discovery via a whole-cell model (Nature Methods) Sunday November 3rd 2013
Jayodita C Sanghvi, Sergi Regot, Silvia Carrasco, Jonathan R Karr, Miriam V Gutschow, Benjamin Bolival, Markus W Covert

66) Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system (Nature Methods) Sunday October 27th 2013
Ben C Collins, Ludovic C Gillet, George Rosenberger, Hannes L R, Anton Vichalkovski, Matthias Gstaiger, Ruedi Aebersold

67) Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition (Nature Methods) Sunday October 27th 2013
Jean-Philippe Lambert, Gordana Ivosev, Amber L Couzens, Brett Larsen, Mikko Taipale, Zhen-Yuan Lin, Quan Zhong, Susan Lindquist, Marc Vidal, Ruedi Aebersold, Tony Pawson, Ron Bonner, Stephen Tate, Anne-Claude Gingras

68) A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat (Nature Methods) Sunday October 27th 2013
Rita L Strack, Matthew D Disney, Samie R Jaffrey

69) Quantitative assessment of single-cell RNA-sequencing methods (Nature Methods) Sunday October 20th 2013
Angela R Wu, Norma F Neff, Tomer Kalisky, Piero Dalerba, Barbara Treutlein, Michael E Rothenberg, Francis M Mburu, Gary L Mantalas, Sopheak Sim, Michael F Clarke, Stephen R Quake

70) High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias (Nature Methods) Sunday October 20th 2013
Emanuel J P Nazareth, Joel E E Ostblom, Petra B L, Shreya Shukla, Manuel M Alvarez, Steve K W Oh, Ting Yin, Peter W Zandstra

71) Metagenomic species profiling using universal phylogenetic marker genes (Nature Methods) Sunday October 20th 2013
Shinichi Sunagawa, Daniel R Mende, Georg Zeller, Fernando Izquierdo-Carrasco, Simon A Berger, Jens Roat Kultima, Luis Pedro Coelho, Manimozhiyan Arumugam, Julien Tap, Henrik Bj, Simon Rasmussen, S, Oluf Pedersen, Francisco Guarner, Willem M de Vos, Jun Wang, Junhua Li, Jo, S Dusko Ehrlich, Alexandros Stamatakis, Peer Bork

72) Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells (Nature Methods) Sunday October 13th 2013
Shigeki Kiyonaka, Taketoshi Kajimoto, Reiko Sakaguchi, Daisuke Shinmi, Mariko Omatsu-Kanbe, Hiroshi Matsuura, Hiromi Imamura, Takenao Yoshizaki, Itaru Hamachi, Takashi Morii, Yasuo Mori

73) Formation of targeted monovalent quantum dots by steric exclusion (Nature Methods) Sunday October 13th 2013
Justin Farlow, Daeha Seo, Kyle E Broaders, Marcus J Taylor, Zev J Gartner, Young-wook Jun

74) DGIdb: mining the druggable genome (Nature Methods) Sunday October 13th 2013
Malachi Griffith, Obi L Griffith, Adam C Coffman, James V Weible, Josh F McMichael, Nicholas C Spies, James Koval, Indraniel Das, Matthew B Callaway, James M Eldred, Christopher A Miller, Janakiraman Subramanian, Ramaswamy Govindan, Runjun D Kumar, Ron Bose, Li Ding, Jason R Walker, David E Larson, David J Dooling, Scott M Smith, Timothy J Ley, Elaine R Mardis, Richard K Wilson

75) Detergent-free mass spectrometry of membrane protein complexes (Nature Methods) Sunday October 13th 2013
Jonathan T S Hopper, Yvonne Ting-Chun Yu, Dianfan Li, Alison Raymond, Mark Bostock, Idlir Liko, Victor Mikhailov, Arthur Laganowsky, Justin L P Benesch, Martin Caffrey, Daniel Nietlispach, Carol V Robinson

76) Image-based transcriptomics in thousands of single human cells at single-molecule resolution (Nature Methods) Sunday October 6th 2013
Nico Battich, Thomas Stoeger, Lucas Pelkmans

77) Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position (Nature Methods) Sunday October 6th 2013
Jason D Buenrostro, Paul G Giresi, Lisa C Zaba, Howard Y Chang, William J Greenleaf

78) Instant super-resolution imaging in live cells and embryos via analog image processing (Nature Methods) Sunday October 6th 2013
Andrew G York, Panagiotis Chandris, Damian Dalle Nogare, Jeffrey Head, Peter Wawrzusin, Robert S Fischer, Ajay Chitnis, Hari Shroff

79) Predicting functional gene interactions with the hierarchical interaction score (Nature Methods) Sunday October 6th 2013
Berend Snijder, Prisca Liberali, Mathieu Frechin, Thomas Stoeger, Lucas Pelkmans

80) Orthogonal Cas9 proteins for RNA-guided gene regulation and editing (Nature Methods) Sunday September 29th 2013
Kevin M Esvelt, Prashant Mali, Jonathan L Braff, Mark Moosburner, Stephanie J Yaung, George M Church

81) Improved low-resolution crystallographic refinement with Phenix and Rosetta (Nature Methods) Sunday September 29th 2013
Frank DiMaio, Nathaniel Echols, Jeffrey J Headd, Thomas C Terwilliger, Paul D Adams, David Baker

82) Differential abundance analysis for microbial marker-gene surveys (Nature Methods) Sunday September 29th 2013
Joseph N Paulson, O Colin Stine, H, Mihai Pop

83) eXtasy: variant prioritization by genomic data fusion (Nature Methods) Sunday September 29th 2013
Alejandro Sifrim, Dusan Popovic, Leon-Charles Tranchevent, Amin Ardeshirdavani, Ryo Sakai, Peter Konings, Joris R Vermeesch, Jan Aerts, Bart De Moor, Yves Moreau

84) Accounting for technical noise in single-cell RNA-seq experiments (Nature Methods) Sunday September 22nd 2013
Philip Brennecke, Simon Anders, Jong Kyoung Kim, Aleksandra A Ko, Xiuwei Zhang, Valentina Proserpio, Bianka Baying, Vladimir Benes, Sarah A Teichmann, John C Marioni, Marcus G Heisler

85) Smart-seq2 for sensitive full-length transcriptome profiling in single cells (Nature Methods) Sunday September 22nd 2013
Simone Picelli, Åsa K Björklund, Omid R Faridani, Sven Sagasser, G, Rickard Sandberg

86) Inducible control of gene expression with destabilized Cre (Nature Methods) Sunday September 22nd 2013
Richard Sando, Karsten Baumgaertel, Simon Pieraut, Nina Torabi-Rander, Thomas J Wandless, Mark Mayford, Anton Maximov

87) Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia (Nature Methods) Sunday September 22nd 2013
Steven Su, Siew Cheng Phua, Robert DeRose, Shuhei Chiba, Keishi Narita, Peter N Kalugin, Toshiaki Katada, Kenji Kontani, Sen Takeda, Takanari Inoue

88) TCPA: a resource for cancer functional proteomics data (Nature Methods) Sunday September 15th 2013
Jun Li, Yiling Lu, Rehan Akbani, Zhenlin Ju, Paul L Roebuck, Wenbin Liu, Ji-Yeon Yang, Bradley M Broom, Roeland G W Verhaak, David W Kane, Chris Wakefield, John N Weinstein, Gordon B Mills, Han Liang

89) Network-based stratification of tumor mutations (Nature Methods) Sunday September 15th 2013
Matan Hofree, John P Shen, Hannah Carter, Andrew Gross, Trey Ideker

90) IntOGen-mutations identifies cancer drivers across tumor types (Nature Methods) Sunday September 15th 2013
Abel Gonzalez-Perez, Christian Perez-Llamas, Jordi Deu-Pons, David Tamborero, Michael P Schroeder, Alba Jene-Sanz, Alberto Santos, Nuria Lopez-Bigas

91) Exploiting tertiary structure through local folds for crystallographic phasing (Nature Methods) Sunday September 15th 2013
Massimo Sammito, Claudia Mill, Dayt, I, Kathrin Meindl, Ivan De Marino, Giovanna Petrillo, Rub, Jos, Kornelius Zeth, George M Sheldrick, Isabel Us

92) Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light (Nature Methods) Sunday September 8th 2013
Tina Schr, Robert Prevedel, Karin Aumayr, Manuel Zimmer, Alipasha Vaziri

93) Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein (Nature Methods) Sunday September 8th 2013
Shenlin Wang, Rachel A Munro, Lichi Shi, Izuru Kawamura, Takashi Okitsu, Akimori Wada, So-Young Kim, Kwang-Hwan Jung, Leonid S Brown, Vladimir Ladizhansky

94) Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination (Nature Methods) Sunday September 1st 2013
Daniel J Dickinson, Jordan D Ward, David J Reiner, Bob Goldstein

95) Engineering of weak helper interactions for high-efficiency FRET probes (Nature Methods) Sunday September 1st 2013
Raik Gr, Julia V Burnier, Tony Ferrar, Violeta Beltran-Sastre, Fran, Almer M van der Sloot, Raquel Garcia-Olivas, Arrate Mallabiabarrena, Xavier Sanjuan, Timo Zimmermann, Luis Serrano

96) Absolute quantification by droplet digital PCR versus analog real-time PCR (Nature Methods) Sunday September 1st 2013
Christopher M Hindson, John R Chevillet, Hilary A Briggs, Emily N Gallichotte, Ingrid K Ruf, Benjamin J Hindson, Robert L Vessella, Muneesh Tewari

97) Practical innovations for high-throughput amplicon sequencing (Nature Methods) Sunday September 1st 2013
Derek S Lundberg, Scott Yourstone, Piotr Mieczkowski, Corbin D Jones, Jeffery L Dangl

98) A reversible gene trap collection empowers haploid genetics in human cells (Nature Methods) Monday August 26th 2013
Tilmann B, Carina Banning, Philipp Hainzl, Richard Schobesberger, Claudia Kerzendorfer, Florian M Pauler, Doris Chen, Nicole Them, Fiorella Schischlik, Manuele Rebsamen, Michal Smida, Ferran Fece de la Cruz, Ana Lapao, Melissa Liszt, Benjamin Eizinger, Philipp M Guenzl, Vincent A Blomen, Tomasz Konopka, Bianca Gapp, Katja Parapatics, Barbara Maier, Johannes St, Wolfgang Fischl, Sejla Salic, M Rita Taba Casari, Sylvia Knapp, Keiryn L Bennett, Christoph Bock, Jacques Colinge, Robert Kralovics, Gustav Ammerer, Georg Casari, Thijn R Brummelkamp, Giulio Superti-Furga, Sebastian M B Nijman

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