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1) Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy (Nature Medicine) Monday May 14th 2012
Angelika Bierhaus, Thomas Fleming, Stoyan Stoyanov, Andreas Leffler, Alexandru Babes, Cristian Neacsu, Susanne K Sauer, Mirjam Eberhardt, Martina Schnölzer, Felix Lasischka, Winfried L Neuhuber, Tatjana I Kichko, Ilze Konrade, Ralf Elvert, Walter Mier, Valdis Pirags, Ivan K Lukic, Michael Morcos, Thomas Dehmer, Naila Rabbani, Paul J Thornalley, Diane Edelstein, Carla Nau, Josephine Forbes, Per M Humpert, Markus Schwaninger, Dan Ziegler, David M Stern, Mark E Cooper, Uwe Haberkorn, Michael Brownlee, Peter W Reeh, Peter P Nawroth

2) NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action (Nature Medicine) Monday May 14th 2012
Liang Sheng, Yingjiang Zhou, Zheng Chen, Decheng Ren, Kae Won Cho, Lin Jiang, Hong Shen, Yoshiteru Sasaki, Liangyou Rui

3) ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1 (Nature Medicine) Monday May 14th 2012
Inbal Avraham-Davidi, Yona Ely, Van N Pham, Daniel Castranova, Moshe Grunspan, Guy Malkinson, Liron Gibbs-Bar, Oded Mayseless, Gabriella Allmog, Brigid Lo, Carmen M Warren, Tom T Chen, Josette Ungos, Kameha Kidd, Kenna Shaw, Ilana Rogachev, Wuzhou Wan, Philip M Murphy, Steven A Farber, Liran Carmel, Gregory S Shelness, M Luisa Iruela-Arispe, Brant M Weinstein, Karina Yaniv

4) Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration (Nature Medicine) Sunday May 6th 2012
Zheng Sun, Russell A Miller, Rajesh T Patel, Jie Chen, Ravindra Dhir, Hong Wang, Dongyan Zhang, Mark J Graham, Terry G Unterman, Gerald I Shulman, Carole Sztalryd, Michael J Bennett, Rexford S Ahima, Morris J Birnbaum, Mitchell A Lazar

5) Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo (Nature Medicine) Sunday May 6th 2012
Shuangxi Wang, Cheng Zhang, Miao Zhang, Bin Liang, Huaiping Zhu, Jiyeon Lee, Benoit Viollet, Lijun Xia, Yun Zhang, Ming-Hui Zou

6) Monoclonal TCR-redirected tumor cell killing (Nature Medicine) Sunday May 6th 2012
Nathaniel Liddy, Giovanna Bossi, Katherine J Adams, Anna Lissina, Tara M Mahon, Namir J Hassan, Jessie Gavarret, Frayne C Bianchi, Nicholas J Pumphrey, Kristin Ladell, Emma Gostick, Andrew K Sewell, Nikolai M Lissin, Naomi E Harwood, Peter E Molloy, Yi Li, Brian J Cameron, Malkit Sami, Emma E Baston, Penio T Todorov, Samantha J Paston, Rebecca E Dennis, Jane V Harper, Steve M Dunn, Rebecca Ashfield, Andy Johnson, Yvonne McGrath, Gabriela Plesa, Carl H June, Michael Kalos, David A Price, Annelise Vuidepot, Daniel D Williams, Deborah H Sutton, Bent K Jakobsen

7) Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology (Nature Medicine) Sunday April 29th 2012
Bryan C Petersen, Alison L Budelsky, Alan P Baptist, Matthew A Schaller, Nicholas W Lukacs

8) Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota (Nature Medicine) Sunday April 22nd 2012
Janelle S Ayres, Norver J Trinidad, Russell E Vance

9) Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance (Nature Medicine) Sunday April 22nd 2012
Rebecca L Leshan, Megan Greenwald-Yarnell, Christa M Patterson, Ian E Gonzalez, Martin G Myers

10) MRSA epidemic linked to a quickly spreading colonization and virulence determinant (Nature Medicine) Sunday April 22nd 2012
Min Li, Xin Du, Amer E Villaruz, Binh An Diep, Decheng Wang, Yan Song, Yueru Tian, Jinhui Hu, Fangyou Yu, Yuan Lu, Michael Otto

11) Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia (Nature Medicine) Sunday April 15th 2012
Tobias Eckle, Katherine Hartmann, Stephanie Bonney, Susan Reithel, Michel Mittelbronn, Lori A Walker, Brian D Lowes, Jun Han, Christoph H Borchers, Peter M Buttrick, Douglas J Kominsky, Sean P Colgan, Holger K Eltzschig

12) Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury (Nature Medicine) Sunday April 15th 2012
Mohammad Naimul Islam, Shonit R Das, Memet T Emin, Michelle Wei, Li Sun, Kristin Westphalen, David J Rowlands, Sadiqa K Quadri, Sunita Bhattacharya, Jahar Bhattacharya

13) A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle (Nature Medicine) Sunday April 15th 2012
Moritz F Kircher, Adam de la Zerda, Jesse V Jokerst, Cristina L Zavaleta, Paul J Kempen, Erik Mittra, Ken Pitter, Ruimin Huang, Carl Campos, Frezghi Habte, Robert Sinclair, Cameron W Brennan, Ingo K Mellinghoff, Eric C Holland, Sanjiv S Gambhir

14) Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides (Nature Medicine) Sunday April 8th 2012
Katherina Siewert, Joachim Malotka, Naoto Kawakami, Hartmut Wekerle, Reinhard Hohlfeld, Klaus Dornmair

15) RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing (Nature Medicine) Sunday April 1st 2012
Wei Guo, Sebastian Schafer, Marion L Greaser, Michael H Radke, Martin Liss, Thirupugal Govindarajan, Henrike Maatz, Herbert Schulz, Shijun Li, Amanda M Parrish, Vita Dauksaite, Padmanabhan Vakeel, Sabine Klaassen, Brenda Gerull, Ludwig Thierfelder, Vera Regitz-Zagrosek, Timothy A Hacker, Kurt W Saupe, G William Dec, Patrick T Ellinor, Calum A MacRae, Bastian Spallek, Robert Fischer, Andreas Perrot, Cemil Özcelik, Kathrin Saar, Norbert Hubner, Michael Gotthardt

16) Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia (Nature Medicine) Sunday April 1st 2012
Jiali Li, Jianmin Chen, Christopher L Ricupero, Ronald P Hart, Melanie S Schwartz, Alexander Kusnecov, Karl Herrup

17) Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer (Nature Medicine) Sunday April 1st 2012
Elena Provasi, Pietro Genovese, Angelo Lombardo, Zulma Magnani, Pei-Qi Liu, Andreas Reik, Victoria Chu, David E Paschon, Lei Zhang, Jurgen Kuball, Barbara Camisa, Attilio Bondanza, Giulia Casorati, Maurilio Ponzoni, Fabio Ciceri, Claudio Bordignon, Philip D Greenberg, Michael C Holmes, Philip D Gregory, Luigi Naldini, Chiara Bonini

18) Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation (Nature Medicine) Sunday March 25th 2012
David A Hill, Mark C Siracusa, Michael C Abt, Brian S Kim, Dmytro Kobuley, Masato Kubo, Taku Kambayashi, David F LaRosa, Ellen D Renner, Jordan S Orange, Frederic D Bushman, David Artis

19) NOD2 triggers an interleukin-32–dependent human dendritic cell program in leprosy (Nature Medicine) Sunday March 25th 2012
Mirjam Schenk, Stephan R Krutzik, Peter A Sieling, Delphine J Lee, Rosane M B Teles, Maria Teresa Ochoa, Evangelia Komisopoulou, Euzenir N Sarno, Thomas H Rea, Thomas G Graeber, Soohyun Kim, Genhong Cheng, Robert L Modlin

20) Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin (Nature Medicine) Sunday March 18th 2012
Guey-Ying Liao, Juan Ji An, Kusumika Gharami, Emily G Waterhouse, Filip Vanevski, Kevin R Jones, Baoji Xu

21) A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer (Nature Medicine) Sunday March 18th 2012
King Pan Ng, Axel M Hillmer, Charles T H Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S M Teo, Pramila N Ariyaratne, Naoto Takahashi, Kenichi Sawada, Yao Fei, Sheila Soh, Wah Heng Lee, John W J Huang, John C Allen, Xing Yi Woo, Niranjan Nagarajan, Vikrant Kumar, Anbupalam Thalamuthu, Wan Ting Poh, Ai Leen Ang, Hae Tha Mya, Gee Fung How, Li Yi Yang, Liang Piu Koh, Balram Chowbay, Chia-Tien Chang, Veera S Nadarajan, Wee Joo Chng, Hein Than, Lay Cheng Lim, Yeow Tee Goh, Shenli Zhang, Dianne Poh, Patrick Tan, Ju-Ee Seet, Mei-Kim Ang, Noan-Minh Chau, Quan-Sing Ng, Daniel S W Tan, Manabu Soda, Kazutoshi Isobe, Markus M Nöthen, Tien Y Wong, Atif Shahab, Xiaoan Ruan, Valère Cacheux-Rataboul, Wing-Kin Sung, Eng Huat Tan, Yasushi Yatabe, Hiroyuki Mano, Ross A Soo, Tan Min Chin, Wan-Teck Lim, Yijun Ruan, S Tiong Ong

22) Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis (Nature Medicine) Sunday March 18th 2012
Brian D Gulbransen, Mohammad Bashashati, Simon A Hirota, Xianyong Gui, Jane A Roberts, Justin A MacDonald, Daniel A Muruve, Derek M McKay, Paul L Beck, Gary M Mawe, Roger J Thompson, Keith A Sharkey

23) CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis (Nature Medicine) Sunday March 18th 2012
Mashito Sakai, Michihiro Matsumoto, Tomoko Tujimura, Cao Yongheng, Tetsuya Noguchi, Kenjiro Inagaki, Hiroshi Inoue, Tetsuya Hosooka, Kazuo Takazawa, Yoshiaki Kido, Kazuki Yasuda, Ryuji Hiramatsu, Yasushi Matsuki, Masato Kasuga

24) Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia (Nature Medicine) Sunday March 11th 2012
Tino Schenk, Weihsu Claire Chen, Stefanie Göllner, Louise Howell, Liqing Jin, Katja Hebestreit, Hans-Ulrich Klein, Andreea C Popescu, Alan Burnett, Ken Mills, Robert A Casero, Laurence Marton, Patrick Woster, Mark D Minden, Martin Dugas, Jean C Y Wang, John E Dick, Carsten Müller-Tidow, Kevin Petrie, Arthur Zelent

25) Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell (Nature Medicine) Sunday March 11th 2012
Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe

26) Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop (Nature Medicine) Sunday March 4th 2012
Nicola Aceto, Nina Sausgruber, Heike Brinkhaus, Dimos Gaidatzis, Georg Martiny-Baron, Giovanni Mazzarol, Stefano Confalonieri, Micaela Quarto, Guang Hu, Piotr J Balwierz, Mikhail Pachkov, Stephen J Elledge, Erik van Nimwegen, Michael B Stadler, Mohamed Bentires-Alj

27) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease (Nature Medicine) Sunday March 4th 2012
Luke Boulter, Olivier Govaere, Tom G Bird, Sorina Radulescu, Prakash Ramachandran, Antonella Pellicoro, Rachel A Ridgway, Sang Soo Seo, Bart Spee, Nico Van Rooijen, Owen J Sansom, John P Iredale, Sally Lowell, Tania Roskams, Stuart J Forbes

28) IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction (Nature Medicine) Sunday March 4th 2012
Makoto Kudo, Andrew C Melton, Chun Chen, Mary B Engler, Katherine E Huang, Xin Ren, Yanli Wang, Xin Bernstein, John T Li, Kamran Atabai, Xiaozhu Huang, Dean Sheppard

29) Vitamin E decreases bone mass by stimulating osteoclast fusion (Nature Medicine) Sunday March 4th 2012
Koji Fujita, Makiko Iwasaki, Hiroki Ochi, Toru Fukuda, Chengshan Ma, Takeshi Miyamoto, Kimitaka Takitani, Takako Negishi-Koga, Satoko Sunamura, Tatsuhiko Kodama, Hiroshi Takayanagi, Hiroshi Tamai, Shigeaki Kato, Hiroyuki Arai, Kenichi Shinomiya, Hiroshi Itoh, Atsushi Okawa, Shu Takeda

30) Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women (Nature Medicine) Sunday February 26th 2012
Yvonne A R White, Dori C Woods, Yasushi Takai, Osamu Ishihara, Hiroyuki Seki, Jonathan L Tilly

31) Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL (Nature Medicine) Sunday February 26th 2012
Giusy Della Gatta, Teresa Palomero, Arianne Perez-Garcia, Alberto Ambesi-Impiombato, Mukesh Bansal, Zachary W Carpenter, Kim De Keersmaecker, Xavier Sole, Luyao Xu, Elisabeth Paietta, Janis Racevskis, Peter H Wiernik, Jacob M Rowe, Jules P Meijerink, Andrea Califano, Adolfo A Ferrando

32) High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions (Nature Medicine) Sunday February 26th 2012
Roberto Di Niro, Luka Mesin, Nai-Ying Zheng, Jorunn Stamnaes, Michael Morrissey, Jane-Hwei Lee, Min Huang, Rasmus Iversen, M Fleur du Pré, Shuo-Wang Qiao, Knut E A Lundin, Patrick C Wilson, Ludvig M Sollid

33) Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging (Nature Medicine) Sunday February 26th 2012
Mya S Thu, L Henry Bryant, Tiziana Coppola, E Kay Jordan, Matthew D Budde, Bobbi K Lewis, Aneeka Chaudhry, Jiaqiang Ren, Nadimpalli Ravi S Varma, Ali S Arbab, Joseph A Frank

34) Blockade of PDGFR-β activation eliminates morphine analgesic tolerance (Nature Medicine) Sunday February 19th 2012
Yan Wang, Katherine Barker, Shanping Shi, Miguel Diaz, Bing Mo, Howard B Gutstein

35) USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma (Nature Medicine) Sunday February 19th 2012
Pieter J A Eichhorn, Laura Rodón, Alba Gonzàlez-Juncà, Annette Dirac, Magüi Gili, Elena Martínez-Sáez, Claudia Aura, Ignasi Barba, Vicente Peg, Aleix Prat, Isabel Cuartas, Jose Jimenez, David García-Dorado, Juan Sahuquillo, Réné Bernards, José Baselga, Joan Seoane

36) Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1 (Nature Medicine) Sunday February 19th 2012
Mingjian Lu, Min Wan, Karla F Leavens, Qingwei Chu, Bobby R Monks, Sully Fernandez, Rexford S Ahima, Kohjiro Ueki, C Ronald Kahn, Morris J Birnbaum

37) Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis (Nature Medicine) Sunday February 19th 2012
Kazuhiro Maeda, Yasuhiro Kobayashi, Nobuyuki Udagawa, Shunsuke Uehara, Akihiro Ishihara, Toshihide Mizoguchi, Yuichiro Kikuchi, Ichiro Takada, Shigeaki Kato, Shuichi Kani, Michiru Nishita, Keishi Marumo, T John Martin, Yasuhiro Minami, Naoyuki Takahashi

38) A quantitative basis for antiretroviral therapy for HIV-1 infection (Nature Medicine) Sunday February 19th 2012
Benjamin L Jilek, Melissa Zarr, Maame E Sampah, S Alireza Rabi, Cynthia K Bullen, Jun Lai, Lin Shen, Robert F Siliciano

39) Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases (Nature Medicine) Sunday February 19th 2012
Alan J Russell, James J Hartman, Aaron C Hinken, Alexander R Muci, Raja Kawas, Lena Driscoll, Guillermo Godinez, Kenneth H Lee, David Marquez, William F Browne, Michael M Chen, David Clarke, Scott E Collibee, Marc Garard, Richard Hansen, Zhiheng Jia, Pu-Ping Lu, Hector Rodriguez, Khalil G Saikali, Julia Schaletzky, Vipin Vijayakumar, Daniel L Albertus, Dennis R Claflin, David J Morgans, Bradley P Morgan, Fady I Malik

40) KIF5B-RET fusions in lung adenocarcinoma (Nature Medicine) Sunday February 12th 2012
Takashi Kohno, Hitoshi Ichikawa, Yasushi Totoki, Kazuki Yasuda, Masaki Hiramoto, Takao Nammo, Hiromi Sakamoto, Koji Tsuta, Koh Furuta, Yoko Shimada, Reika Iwakawa, Hideaki Ogiwara, Takahiro Oike, Masato Enari, Aaron J Schetter, Hirokazu Okayama, Aage Haugen, Vidar Skaug, Suenori Chiku, Itaru Yamanaka, Yasuhito Arai, Shun-ichi Watanabe, Ikuo Sekine, Seishi Ogawa, Curtis C Harris, Hitoshi Tsuda, Teruhiko Yoshida, Jun Yokota, Tatsuhiro Shibata

41) Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies (Nature Medicine) Sunday February 12th 2012
Doron Lipson, Marzia Capelletti, Roman Yelensky, Geoff Otto, Alex Parker, Mirna Jarosz, John A Curran, Sohail Balasubramanian, Troy Bloom, Kristina W Brennan, Amy Donahue, Sean R Downing, Garrett M Frampton, Lazaro Garcia, Frank Juhn, Kathy C Mitchell, Emily White, Jared White, Zac Zwirko, Tamar Peretz, Hovav Nechushtan, Lior Soussan-Gutman, Jhingook Kim, Hidefumi Sasaki, Hyeong Ryul Kim, Seung-il Park, Dalia Ercan, Christine E Sheehan, Jeffrey S Ross, Maureen T Cronin, Pasi A Jänne, Philip J Stephens

42) RET, ROS1 and ALK fusions in lung cancer (Nature Medicine) Sunday February 12th 2012
Kengo Takeuchi, Manabu Soda, Yuki Togashi, Ritsuro Suzuki, Seiji Sakata, Satoko Hatano, Reimi Asaka, Wakako Hamanaka, Hironori Ninomiya, Hirofumi Uehara, Young Lim Choi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hiroyuki Mano, Yuichi Ishikawa

43) Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis (Nature Medicine) Sunday February 5th 2012
Hikaru Sugimoto, Valerie S LeBleu, Dattatreyamurty Bosukonda, Peter Keck, Gangadhar Taduri, Wibke Bechtel, Hirokazu Okada, William Carlson, Philippe Bey, Mary Rusckowski, Björn Tampe, Desiree Tampe, Keizo Kanasaki, Michael Zeisberg, Raghu Kalluri

44) Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass (Nature Medicine) Sunday February 5th 2012
Min Guan, Wei Yao, Ruiwu Liu, Kit S Lam, Jan Nolta, Junjing Jia, Brian Panganiban, Liping Meng, Ping Zhou, Mohammad Shahnazari, Robert O Ritchie, Nancy E Lane

45) MicroRNA-21 targets the vitamin D–dependent antimicrobial pathway in leprosy (Nature Medicine) Sunday January 29th 2012
Philip T Liu, Matthew Wheelwright, Rosane Teles, Evangelia Komisopoulou, Kristina Edfeldt, Benjamin Ferguson, Manali D Mehta, Aria Vazirnia, Thomas H Rea, Euzenir N Sarno, Thomas G Graeber, Robert L Modlin

46) Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans (Nature Medicine) Sunday January 29th 2012
Tom M Wilkinson, Chris K F Li, Cecilia S C Chui, Arthur K Y Huang, Molly Perkins, Julia C Liebner, Rob Lambkin-Williams, Anthony Gilbert, John Oxford, Ben Nicholas, Karl J Staples, Tao Dong, Daniel C Douek, Andrew J McMichael, Xiao-Ning Xu

47) Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export (Nature Medicine) Sunday January 29th 2012
Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

48) A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy (Nature Medicine) Sunday January 29th 2012
Ge Zhang, Baosheng Guo, Heng Wu, Tao Tang, Bao-Ting Zhang, Lizhen Zheng, Yixin He, Zhijun Yang, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang, Ling Qin

49) 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas (Nature Medicine) Thursday January 26th 2012
Changho Choi, Sandeep K Ganji, Ralph J DeBerardinis, Kimmo J Hatanpaa, Dinesh Rakheja, Zoltan Kovacs, Xiao-Li Yang, Tomoyuki Mashimo, Jack M Raisanen, Isaac Marin-Valencia, Juan M Pascual, Christopher J Madden, Bruce E Mickey, Craig M Malloy, Robert M Bachoo, Elizabeth A Maher

50) Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer (Nature Medicine) Monday January 23rd 2012
Clara Montagut, Alba Dalmases, Beatriz Bellosillo, Marta Crespo, Silvia Pairet, Mar Iglesias, Marta Salido, Manuel Gallen, Scot Marsters, Siao Ping Tsai, André Minoche, Seshagiri Somasekar, Sergi Serrano, Heinz Himmelbauer, Joaquim Bellmunt, Ana Rovira, Jeff Settleman, Francesc Bosch, Joan Albanell

51) Prostaglandin E2 promotes intestinal tumor growth via DNA methylation (Nature Medicine) Monday January 23rd 2012
Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh, Raymond N DuBois

52) cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function (Nature Medicine) Monday January 23rd 2012
Mirko Jaumann, Juliane Dettling, Martin Gubelt, Ulrike Zimmermann, Andrea Gerling, François Paquet-Durand, Susanne Feil, Stephan Wolpert, Christoph Franz, Ksenya Varakina, Hao Xiong, Niels Brandt, Stephanie Kuhn, Hyun-Soon Geisler, Karin Rohbock, Peter Ruth, Jens Schlossmann, Joachim Hütter, Peter Sandner, Robert Feil, Jutta Engel, Marlies Knipper, Lukas Rüttiger

53) Magnetic resonance imaging of glutamate (Nature Medicine) Monday January 23rd 2012
Kejia Cai, Mohammad Haris, Anup Singh, Feliks Kogan, Joel H Greenberg, Hari Hariharan, John A Detre, Ravinder Reddy

54) An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection (Nature Medicine) Sunday January 15th 2012
Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F Urban, Thomas A Wynn, William C Gause

55) Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids (Nature Medicine) Sunday January 15th 2012
Wenshan Wang, Na Lv, Shasha Zhang, Guanghou Shui, Hui Qian, Jingfeng Zhang, Yuanying Chen, Jing Ye, Yuansheng Xie, Yuemao Shen, Markus R Wenk, Peng Li

56) Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension (Nature Medicine) Sunday January 15th 2012
Oleksandra Prysyazhna, Olena Rudyk, Philip Eaton

57) Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia (Nature Medicine) Wednesday January 11th 2012
Panagiotis Ntziachristos, Aristotelis Tsirigos, Pieter Van Vlierberghe, Jelena Nedjic, Thomas Trimarchi, Maria Sol Flaherty, Dolors Ferres-Marco, Vanina da Ros, Zuojian Tang, Jasmin Siegle, Patrik Asp, Michael Hadler, Isaura Rigo, Kim De Keersmaecker, Jay Patel, Tien Huynh, Filippo Utro, Sandrine Poglio, Jeremy B Samon, Elisabeth Paietta, Janis Racevskis, Jacob M Rowe, Raul Rabadan, Ross L Levine, Stuart Brown, Francoise Pflumio, Maria Dominguez, Adolfo Ferrando, Iannis Aifantis

58) A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20 (Nature Medicine) Monday January 9th 2012
Michael Blank, Yi Tang, Motozo Yamashita, Sandra S Burkett, Steven Y Cheng, Ying E Zhang

59) AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation (Nature Medicine) Monday January 9th 2012
Johanna T Lanner, Dimitra K Georgiou, Adan Dagnino-Acosta, Alina Ainbinder, Qing Cheng, Aditya D Joshi, Zanwen Chen, Viktor Yarotskyy, Joshua M Oakes, Chang Seok Lee, Tanner O Monroe, Arturo Santillan, Keke Dong, Laurie Goodyear, Iskander I Ismailov, George G Rodney, Robert T Dirksen, Susan L Hamilton

60) Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (Nature Medicine) Monday January 9th 2012
Bruno Sainz, Naina Barretto, Danyelle N Martin, Nobuhiko Hiraga, Michio Imamura, Snawar Hussain, Katherine A Marsh, Xuemei Yu, Kazuaki Chayama, Waddah A Alrefai, Susan L Uprichard

61) Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential (Nature Medicine) Sunday December 25th 2011
Netta Sela-Passwell, Raghavendra Kikkeri, Orly Dym, Haim Rozenberg, Raanan Margalit, Rina Arad-Yellin, Miriam Eisenstein, Ori Brenner, Tsipi Shoham, Tamar Danon, Abraham Shanzer, Irit Sagi

62) Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury (Nature Medicine) Sunday December 25th 2011
Ali Ertürk, Christoph P Mauch, Farida Hellal, Friedrich Förstner, Tara Keck, Klaus Becker, Nina Jährling, Heinz Steffens, Melanie Richter, Mark Hübener, Edgar Kramer, Frank Kirchhoff, Hans Ulrich Dodt, Frank Bradke

63) Malaria impairs resistance to Salmonella through heme- and heme oxygenase–dependent dysfunctional granulocyte mobilization (Nature Medicine) Sunday December 18th 2011
Aubrey J Cunnington, J Brian de Souza, Michael Walther, Eleanor M Riley

64) ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression (Nature Medicine) Sunday December 18th 2011
Wolfram Hoetzenecker, Bernd Echtenacher, Emmanuella Guenova, Konrad Hoetzenecker, Florian Woelbing, Jürgen Brück, Anna Teske, Nadejda Valtcheva, Kerstin Fuchs, Manfred Kneilling, Ji-Hyeon Park, Kyu-Han Kim, Kyu-Won Kim, Petra Hoffmann, Claus Krenn, Tsonwin Hai, Kamran Ghoreschi, Tilo Biedermann, Martin Röcken

65) Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway (Nature Medicine) Sunday December 18th 2011
Hyunkyung Jeong, Dena E Cohen, Libin Cui, Andrea Supinski, Jeffrey N Savas, Joseph R Mazzulli, John R Yates, Laura Bordone, Leonard Guarente, Dimitri Krainc

66) Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets (Nature Medicine) Sunday December 18th 2011
Mali Jiang, Jiawei Wang, Jinrong Fu, Lin Du, Hyunkyung Jeong, Tim West, Lan Xiang, Qi Peng, Zhipeng Hou, Huan Cai, Tamara Seredenina, Nicolas Arbez, Shanshan Zhu, Katherine Sommers, Jennifer Qian, Jiangyang Zhang, Susumu Mori, X William Yang, Kellie L K Tamashiro, Susan Aja, Timothy H Moran, Ruth Luthi-Carter, Bronwen Martin, Stuart Maudsley, Mark P Mattson, Robert H Cichewicz, Christopher A Ross, David M Holtzman, Dimitri Krainc, Wenzhen Duan

67) Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice (Nature Medicine) Sunday December 11th 2011
Anette Schneider, Christian Thiel, Jan Rindermann, Charles DeRossi, Diana Popovici, Georg F Hoffmann, Hermann-Josef Gröne, Christian Körner

68) Reciprocal repression between P53 and TCTP (Nature Medicine) Sunday December 11th 2011
Robert Amson, Salvatore Pece, Alexandra Lespagnol, Rajesh Vyas, Giovanni Mazzarol, Daniela Tosoni, Ivan Colaluca, Giuseppe Viale, Sylvie Rodrigues-Ferreira, Jessika Wynendaele, Olivier Chaloin, Johan Hoebeke, Jean-Christophe Marine, Pier Paolo Di Fiore, Adam Telerman

69) EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers (Nature Medicine) Sunday December 11th 2011
Michela Garofalo, Giulia Romano, Gianpiero Di Leva, Gerard Nuovo, Young-Jun Jeon, Apollinaire Ngankeu, Jin Sun, Francesca Lovat, Hansjuerg Alder, Gerolama Condorelli, Jeffrey A Engelman, Mayumi Ono, Jin Kyung Rho, Luciano Cascione, Stefano Volinia, Kenneth P Nephew, Carlo M Croce

70) Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling (Nature Medicine) Sunday December 11th 2011
Victor W Wong, Kristine C Rustad, Satoshi Akaishi, Michael Sorkin, Jason P Glotzbach, Michael Januszyk, Emily R Nelson, Kemal Levi, Josemaria Paterno, Ivan N Vial, Anna A Kuang, Michael T Longaker, Geoffrey C Gurtner

71) Key contribution of CPEB4-mediated translational control to cancer progression (Nature Medicine) Sunday December 4th 2011
Elena Ortiz-Zapater, David Pineda, Neus Martínez-Bosch, Gonzalo Fernández-Miranda, Mar Iglesias, Francesc Alameda, Mireia Moreno, Carolina Eliscovich, Eduardo Eyras, Francisco X Real, Raúl Méndez, Pilar Navarro

72) PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells (Nature Medicine) Sunday December 4th 2011
Yuan Xue, Sharon Lim, Yunlong Yang, Zongwei Wang, Lasse Dahl Ejby Jensen, Eva-Maria Hedlund, Patrik Andersson, Masakiyo Sasahara, Ola Larsson, Dagmar Galter, Renhai Cao, Kayoko Hosaka, Yihai Cao

73) In vivo imaging of ligand receptor binding with Gaussia luciferase complementation (Nature Medicine) Sunday December 4th 2011
Kathryn E Luker, Laura Anne Mihalko, Bradley T Schmidt, Sarah A Lewin, Paramita Ray, Dmitry Shcherbo, Dmitriy M Chudakov, Gary D Luker

74) Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease (Nature Medicine) Tuesday November 29th 2011
Motoko Koyama, Rachel D Kuns, Stuart D Olver, Neil C Raffelt, Yana A Wilson, Alistair L J Don, Katie E Lineburg, Melody Cheong, Renee J Robb, Kate A Markey, Antiopi Varelias, Bernard Malissen, Günter J Hämmerling, Andrew D Clouston, Christian R Engwerda, Purnima Bhat, Kelli P A MacDonald, Geoffrey R Hill

75) Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease (Nature Medicine) Sunday November 27th 2011
Mohammad R Ebrahimkhani, Fiona Oakley, Lindsay B Murphy, Jelena Mann, Anna Moles, Maria J Perugorria, Elizabeth Ellis, Anne F Lakey, Alastair D Burt, Angela Douglass, Matthew C Wright, Steven A White, Fabrice Jaffré, Luc Maroteaux, Derek A Mann

76) Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome (Nature Medicine) Sunday November 27th 2011
Sergiu P Paşca, Thomas Portmann, Irina Voineagu, Masayuki Yazawa, Aleksandr Shcheglovitov, Anca M Paşca, Branden Cord, Theo D Palmer, Sachiko Chikahisa, Seiji Nishino, Jonathan A Bernstein, Joachim Hallmayer, Daniel H Geschwind, Ricardo E Dolmetsch

77) A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design (Nature Medicine) Sunday November 20th 2011
Fikri Y Avci, Xiangming Li, Moriya Tsuji, Dennis L Kasper

78) Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α (Nature Medicine) Sunday November 20th 2011
Yi Liu, Lei Wang, Takashi Kikuiri, Kentaro Akiyama, Chider Chen, Xingtian Xu, Ruili Yang, WanJun Chen, Songlin Wang, Songtao Shi

79) miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response (Nature Medicine) Sunday November 20th 2011
Bogdan Mateescu, Luciana Batista, Melissa Cardon, Tina Gruosso, Yvan de Feraudy, Odette Mariani, André Nicolas, Jean-Philippe Meyniel, Paul Cottu, Xavier Sastre-Garau, Fatima Mechta-Grigoriou

80) Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut (Nature Medicine) Sunday November 20th 2011
Natalia Shulzhenko, Andrey Morgun, William Hsiao, Michele Battle, Michael Yao, Oksana Gavrilova, Marlene Orandle, Lloyd Mayer, Andrew J Macpherson, Kathy D McCoy, Claire Fraser-Liggett, Polly Matzinger

81) The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis (Nature Medicine) Sunday November 20th 2011
Merit Cudkowicz, Michael E Bozik, Evan W Ingersoll, Robert Miller, Hiroshi Mitsumoto, Jeremy Shefner, Dan H Moore, David Schoenfeld, James L Mather, Donald Archibald, Mary Sullivan, Craig Amburgey, Juliet Moritz, Valentin K Gribkoff

82) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer (Nature Medicine) Sunday November 20th 2011
Dan R Robinson, Shanker Kalyana-Sundaram, Yi-Mi Wu, Sunita Shankar, Xuhong Cao, Bushra Ateeq, Irfan A Asangani, Matthew Iyer, Christopher A Maher, Catherine S Grasso, Robert J Lonigro, Michael Quist, Javed Siddiqui, Rohit Mehra, Xiaojun Jing, Thomas J Giordano, Michael S Sabel, Celina G Kleer, Nallasivam Palanisamy, Rachael Natrajan, Maryou B Lambros, Jorge S Reis-Filho, Chandan Kumar-Sinha, Arul M Chinnaiyan

83) A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism (Nature Medicine) Sunday November 13th 2011
Arlee Fafalios, Jihong Ma, Xinping Tan, John Stoops, Jianhua Luo, Marie C DeFrances, Reza Zarnegar

84) Oxidation of CaMKII determines the cardiotoxic effects of aldosterone (Nature Medicine) Sunday November 13th 2011
B Julie He, Mei-ling A Joiner, Madhu V Singh, Elizabeth D Luczak, Paari Dominic Swaminathan, Olha M Koval, William Kutschke, Chantal Allamargot, Jinying Yang, Xiaoqun Guan, Kathy Zimmerman, Isabella M Grumbach, Robert M Weiss, Douglas R Spitz, Curt D Sigmund, W Matthijs Blankesteijn, Stephane Heymans, Peter J Mohler, Mark E Anderson

85) Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells (Nature Medicine) Sunday November 13th 2011
Dilan Dissanayake, Håkan Hall, Nancy Berg-Brown, Alisha R Elford, Sara R Hamilton, Kiichi Murakami, Leslie Summers Deluca, Jennifer L Gommerman, Pamela S Ohashi

86) A MEK-independent role for CRAF in mitosis and tumor progression (Nature Medicine) Sunday November 13th 2011
Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Maria Fernanda Camargo, Sudarshan Anand, Aleksandra Franovic, Sara M Weis, Sunil J Advani, Eric A Murphy, David A Cheresh

87) Identification of a central role for complement in osteoarthritis (Nature Medicine) Sunday November 6th 2011
Qian Wang, Andrew L Rozelle, Christin M Lepus, Carla R Scanzello, Jason J Song, D Meegan Larsen, James F Crish, Gurkan Bebek, Susan Y Ritter, Tamsin M Lindstrom, Inyong Hwang, Heidi H Wong, Leonardo Punzi, Angelo Encarnacion, Mehrdad Shamloo, Stuart B Goodman, Tony Wyss-Coray, Steven R Goldring, Nirmal K Banda, Joshua M Thurman, Reuben Gobezie, Mary K Crow, V Michael Holers, David M Lee, William H Robinson

88) Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules (Nature Medicine) Sunday November 6th 2011
Makoto Mitsunaga, Mikako Ogawa, Nobuyuki Kosaka, Lauren T Rosenblum, Peter L Choyke, Hisataka Kobayashi

89) Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo (Nature Medicine) Sunday November 6th 2011
Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R McCarthy, Vasilis Ntziachristos, Brett E Bouma, Farouc A Jaffer, Guillermo J Tearney

90) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells (Nature Medicine) Sunday October 30th 2011
Helga Ellingsgaard, Irina Hauselmann, Beat Schuler, Abdella M Habib, Laurie L Baggio, Daniel T Meier, Elisabeth Eppler, Karim Bouzakri, Stephan Wueest, Yannick D Muller, Ann Maria Kruse Hansen, Manfred Reinecke, Daniel Konrad, Max Gassmann, Frank Reimann, Philippe A Halban, Jesper Gromada, Daniel J Drucker, Fiona M Gribble, Jan A Ehses, Marc Y Donath

91) Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth (Nature Medicine) Sunday October 30th 2011
Kristin M Nieman, Hilary A Kenny, Carla V Penicka, Andras Ladanyi, Rebecca Buell-Gutbrod, Marion R Zillhardt, Iris L Romero, Mark S Carey, Gordon B Mills, Gökhan S Hotamisligil, S Diane Yamada, Marcus E Peter, Katja Gwin, Ernst Lengyel

92) Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation (Nature Medicine) Sunday October 23rd 2011
Leylla Badeanlou, Christian Furlan-Freguia, Guang Yang, Wolfram Ruf, Fahumiya Samad

93) Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia (Nature Medicine) Sunday October 23rd 2011
Séverine Coulon, Michaël Dussiot, Damien Grapton, Thiago Trovati Maciel, Pamella Huey Mei Wang, Celine Callens, Meetu Kaushik Tiwari, Saurabh Agarwal, Aurelie Fricot, Julie Vandekerckhove, Houda Tamouza, Yael Zermati, Jean-Antoine Ribeil, Kamel Djedaini, Zeliha Oruc, Virginie Pascal, Geneviève Courtois, Bertrand Arnulf, Marie-Alexandra Alyanakian, Patrick Mayeux, Tomas Leanderson, Marc Benhamou, Michel Cogné, Renato C Monteiro, Olivier Hermine, Ivan C Moura

94) Suppression of bone formation by osteoclastic expression of semaphorin 4D (Nature Medicine) Sunday October 23rd 2011
Takako Negishi-Koga, Masahiro Shinohara, Noriko Komatsu, Haruhiko Bito, Tatsuhiko Kodama, Roland H Friedel, Hiroshi Takayanagi

95) Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes (Nature Medicine) Sunday October 23rd 2011
Yoko S DeRose, Guoying Wang, Yi-Chun Lin, Philip S Bernard, Saundra S Buys, Mark T W Ebbert, Rachel Factor, Cindy Matsen, Brett A Milash, Edward Nelson, Leigh Neumayer, R Lor Randall, Inge J Stijleman, Bryan E Welm, Alana L Welm

96) Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1 (Nature Medicine) Sunday October 16th 2011
Marija Cvetanovic, Jay M Patel, Hugo H Marti, Ameet R Kini, Puneet Opal

97) Thyroid hormone receptor repression is linked to type I pneumocyte–associated respiratory distress syndrome (Nature Medicine) Sunday October 16th 2011
Liming Pei, Mathias Leblanc, Grant Barish, Annette Atkins, Russell Nofsinger, Jamie Whyte, David Gold, Mingxiao He, Kazuko Kawamura, Hai-Ri Li, Michael Downes, Ruth T Yu, Henry C Powell, Jerry B Lingrel, Ronald M Evans

98) Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure (Nature Medicine) Sunday October 16th 2011
Madhuri S Salker, Mark Christian, Jennifer H Steel, Jaya Nautiyal, Stuart Lavery, Geoffrey Trew, Zoe Webster, Marwa Al-Sabbagh, Goverdhan Puchchakayala, Michael Föller, Christian Landles, Andrew M Sharkey, Siobhan Quenby, John D Aplin, Lesley Regan, Florian Lang, Jan J Brosens

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