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1) A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis (Nature Medicine) Monday March 2nd 2015
Bappaditya Dey, Ruchi Jain Dey, Laurene S Cheung, Supriya Pokkali, Haidan Guo, Jong-Hee Lee, William R Bishai

2) Rapid mass spectrometric conversion of tissue biopsy samples into permanent quantitative digital proteome maps (Nature Medicine) Monday March 2nd 2015
Tiannan Guo, Petri Kouvonen, Ching Chiek Koh, Ludovic C Gillet, Witold E Wolski, Hannes L R, George Rosenberger, Ben C Collins, Lorenz C Blum, Silke Gillessen, Markus Joerger, Wolfram Jochum, Ruedi Aebersold

3) LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes (Nature Medicine) Monday February 23rd 2015
Pingping Li, Da Young Oh, Gautam Bandyopadhyay, William S Lagakos, Saswata Talukdar, Olivia Osborn, Andrew Johnson, Heekyung Chung, Rafael Mayoral, Michael Maris, Jachelle M Ofrecio, Sayaka Taguchi, Min Lu, Jerrold M Olefsky

4) Modeling colorectal cancer using CRISPR-Cas9 (Nature Medicine) Monday February 23rd 2015
Mami Matano, Shoichi Date, Mariko Shimokawa, Ai Takano, Masayuki Fujii, Yuki Ohta, Toshiaki Watanabe, Takanori Kanai, Toshiro Sato

5) DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine (Nature Medicine) Monday February 23rd 2015
Keizo Nishikawa, Yoriko Iwamoto, Yasuhiro Kobayashi, Fumiki Katsuoka, Shin-ichi Kawaguchi, Tadayuki Tsujita, Takashi Nakamura, Shigeaki Kato, Masayuki Yamamoto, Hiroshi Takayanagi, Masaru Ishii

6) Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers (Nature Medicine) Monday February 16th 2015
Benjamin G Bitler, Katherine M Aird, Azat Garipov, Hua Li, Michael Amatangelo, Andrew V Kossenkov, David C Schultz, Qin Liu, Ie-Ming Shih, Jose R Conejo-Garcia, David W Speicher, Rugang Zhang

7) A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease (Nature Medicine) Monday February 9th 2015
Mathias Riebold, Christian Kozany, Lee Freiburger, Michael Sattler, Michael Buchfelder, Felix Hausch, G, Marcelo Paez-Pereda

8) Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference (Nature Medicine) Monday February 9th 2015
Chao Liang, Baosheng Guo, Heng Wu, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, Wing Ki Lau, Yu Cao, Zhijun Yang, Cheng Lu, Xiaojuan He, D W T Au, Xiaohua Pan, Bao-Ting Zhang, Changwei Lu, Hongqi Zhang, Kinman Yue, Airong Qian, Peng Shang, Jiake Xu, Lianbo Xiao, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Fuchu He, Lingqiang Zhang, Aiping Lu, Ge Zhang

9) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers (Nature Medicine) Monday February 2nd 2015
Aur, Graziella Griffith, Arran Babbs, Samir El Andaloussi, Kariem Ezzat, Aur, Branislav Dugovic, R, Arnaud Ferry, Thomas Voit, Helge Amthor, Claudia B, Stefan Sch, Matthew J A Wood, Kay E Davies, Cyrille Vaillend, Christian Leumann, Luis Garcia

10) Access sought to tuberculosis drug from nutraceutical company (Nature Medicine) Monday February 2nd 2015
Karl Gruber

11) B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers (Nature Medicine) Monday January 19th 2015
Yoshinori Fukazawa, Richard Lum, Afam A Okoye, Haesun Park, Kenta Matsuda, Jin Young Bae, Shoko I Hagen, Rebecca Shoemaker, Claire Deleage, Carissa Lucero, David Morcock, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Joseph Hesselgesser, Romas Geleziunas, Vanessa M Hirsch, Paul T Edlefsen, Michael Piatak, Jacob D Estes, Jeffrey D Lifson, Louis J Picker

12) Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia (Nature Medicine) Monday January 19th 2015
Steven M Chan, Daniel Thomas, M Ryan Corces-Zimmerman, Seethu Xavy, Suchita Rastogi, Wan-Jen Hong, Feifei Zhao, Bruno C Medeiros, David A Tyvoll, Ravindra Majeti

13) Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction (Nature Medicine) Monday January 12th 2015
Mortimer Korf-Klingebiel, Marc R Reboll, Stefanie Klede, Torben Brod, Andreas Pich, Felix Polten, L Christian Napp, Johann Bauersachs, Arnold Ganser, Eva Brinkmann, Ines Reimann, Tibor Kempf, Hans W Niessen, Jacques Mizrahi, Hans-Joachim Sch, Antonio Iglesias, Maria Bobadilla, Yong Wang, Kai C Wollert

14) Orphan nuclear receptor NR4A1 regulates transforming growth factor- (Nature Medicine) Monday January 12th 2015
Katrin Palumbo-Zerr, Pawel Zerr, Alfiya Distler, Judith Fliehr, Rossella Mancuso, Jingang Huang, Dirk Mielenz, Michal Tomcik, Barbara G F, Carina Scholtysek, Clara Dees, Christian Beyer, Gerhard Kr, Daniel Metzger, Oliver Distler, Georg Schett, J

15) Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes (Nature Medicine) Monday January 12th 2015
Cong Tang, Kashan Ahmed, Andreas Gille, Shun Lu, Hermann-Josef Gr, Sorin Tunaru, Stefan Offermanns

16) Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance (Nature Medicine) Monday January 5th 2015
Sungsoon Fang, Jae Myoung Suh, Shannon M Reilly, Elizabeth Yu, Olivia Osborn, Denise Lackey, Eiji Yoshihara, Alessia Perino, Sandra Jacinto, Yelizaveta Lukasheva, Annette R Atkins, Alexander Khvat, Bernd Schnabl, Ruth T Yu, David A Brenner, Sally Coulter, Christopher Liddle, Kristina Schoonjans, Jerrold M Olefsky, Alan R Saltiel, Michael Downes, Ronald M Evans

17) Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging (Nature Medicine) Monday January 5th 2015
Hoon Hyun, Min Ho Park, Eric A Owens, Hideyuki Wada, Maged Henary, Henricus J M Handgraaf, Alexander L Vahrmeijer, John V Frangioni, Hak Soo Choi

18) High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma (Nature Medicine) Monday December 22nd 2014
Carsten Linnemann, Marit M van Buuren, Laura Bies, Els M E Verdegaal, Remko Schotte, Jorg J A Calis, Sam Behjati, Arno Velds, Henk Hilkmann, Dris el Atmioui, Marten Visser, Michael R Stratton, John B A G Haanen, Hergen Spits, Sjoerd H van der Burg, Ton N M Schumacher

19) Notch controls the survival of memory CD4+ T cells by regulating glucose uptake (Nature Medicine) Monday December 15th 2014
Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita, Koji Yasutomo

20) Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia (Nature Medicine) Monday December 15th 2014
Christopher S Fry, Jonah D Lee, Jyothi Mula, Tyler J Kirby, Janna R Jackson, Fujun Liu, Lin Yang, Christopher L Mendias, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterson

21) In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire (Nature Medicine) Monday December 15th 2014
Brandon J DeKosky, Takaaki Kojima, Alexa Rodin, Wissam Charab, Gregory C Ippolito, Andrew D Ellington, George Georgiou

22) Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles (Nature Medicine) Monday December 15th 2014
Sarah A Stanley, Jeremy Sauer, Ravi S Kane, Jonathan S Dordick, Jeffrey M Friedman

23) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents (Nature Medicine) Monday December 8th 2014
Brian Finan, Bin Yang, Nickki Ottaway, David L Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, Lianshan Zhang, Kirk M Habegger, Katrin Fischer, Jonathan E Campbell, Darleen Sandoval, Randy J Seeley, Konrad Bleicher, Sabine Uhles, William Riboulet, J, Cornelia Hertel, Sara Belli, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Daniel J Drucker, Vasily Gelfanov, Paul T Pfluger, Timo D M, Diego Perez-Tilve, Richard D DiMarchi, Matthias H Tsch

24) The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling (Nature Medicine) Monday December 8th 2014
Renata Grozovsky, Antonija Jurak Begonja, Kaifeng Liu, Gary Visner, John H Hartwig, Herv, Karin M Hoffmeister

25) Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy (Nature Medicine) Monday December 8th 2014
Norihiko Yokoi, Yuko Fukata, Daisuke Kase, Taisuke Miyazaki, Martine Jaegle, Toshika Ohkawa, Naoki Takahashi, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Keiji Imoto, Dies Meijer, Masahiko Watanabe, Masaki Fukata

26) Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis (Nature Medicine) Monday December 8th 2014
Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Bl, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinberg

27) Mutations in G protein (Nature Medicine) Monday December 8th 2014
Akinori Yoda, Guillaume Adelmant, Jerome Tamburini, Bjoern Chapuy, Nobuaki Shindoh, Yuka Yoda, Oliver Weigert, Nadja Kopp, Shuo-Chieh Wu, Sunhee S Kim, Huiyun Liu, Trevor Tivey, Amanda L Christie, Kutlu G Elpek, Joseph Card, Kira Gritsman, Jason Gotlib, Michael W Deininger, Hideki Makishima, Shannon J Turley, Nathalie Javidi-Sharifi, Jaroslaw P Maciejewski, Siddhartha Jaiswal, Benjamin L Ebert, Scott J Rodig, Jeffrey W Tyner, Jarrod A Marto, David M Weinstock, Andrew A Lane

28) Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche (Nature Medicine) Monday December 1st 2014
Hayley Davis, Shazia Irshad, Mukesh Bansal, Hannah Rafferty, Tatjana Boitsova, Chiara Bardella, Emma Jaeger, Annabelle Lewis, Luke Freeman-Mills, Francesc C Giner, Pedro Rodenas-Cuadrado, Sreelakshmi Mallappa, Susan Clark, Huw Thomas, Rosemary Jeffery, Richard Poulsom, Manuel Rodriguez-Justo, Marco Novelli, Runjan Chetty, Andrew Silver, Owen J Sansom, Florian R Greten, Lai Mun Wang, James E East, Ian Tomlinson, Simon J Leedham

29) Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development (Nature Medicine) Monday December 1st 2014
Hyun Mi Kang, Seon Ho Ahn, Peter Choi, Yi-An Ko, Seung Hyeok Han, Frank Chinga, Ae Seo Deok Park, Jianling Tao, Kumar Sharma, James Pullman, Erwin P Bottinger, Ira J Goldberg, Katalin Susztak

30) Targeting (Nature Medicine) Monday November 24th 2014
Siddappa N Byrareddy, Brianne Kallam, James Arthos, Claudia Cicala, Fatima Nawaz, Joseph Hiatt, Ellen N Kersh, Janet M McNicholl, Debra Hanson, Keith A Reimann, Markus Brameier, Lutz Walter, Kenneth Rogers, Ann E Mayne, Paul Dunbar, Tara Villinger, Dawn Little, Tristram G Parslow, Philip J Santangelo, Francois Villinger, Anthony S Fauci, Aftab A Ansari

31) Chronic enrichment of hepatic endoplasmic reticulum (Nature Medicine) Monday November 24th 2014
Ana Paula Arruda, Benedicte M Pers, G, Ekin G, Karen Inouye, G

32) Disruption of the PRKCD (Nature Medicine) Monday November 24th 2014
Ursula Baumann, Vanesa Fern, Martina Rudelius, Simone Lemeer, Roland Rad, Anna-Maria Knorn, Jolanta Slawska, Katharina Engel, Irmela Jeremias, Zhoulei Li, Viktoriya Tomiatti, Anna-Lena Illert, Bianca-Sabrina Targosz, Martin Braun, Sven Perner, Michael Leitges, Wolfram Klapper, Martin Dreyling, Cornelius Miething, Georg Lenz, Andreas Rosenwald, Christian Peschel, Ulrich Keller, Bernhard Kuster, Florian Bassermann

33) A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death (Nature Medicine) Monday November 24th 2014
Monica K Wetzel-Smith, Julie Hunkapiller, Tushar R Bhangale, Karpagam Srinivasan, Janice A Maloney, Jasvinder K Atwal, Susan M Sa, Murat B Yaylaoglu, Oded Foreman, Ward Ortmann, Nisha Rathore, David V Hansen, Marc Tessier-Lavigne, Richard Mayeux, Margaret Pericak-Vance, Jonathan Haines, Lindsay A Farrer, Gerard D Schellenberg, Alison Goate, Timothy W Behrens, Carlos Cruchaga, Ryan J Watts, Robert R Graham

34) Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma (Nature Medicine) Monday November 17th 2014
Rintaro Hashizume, Noemi Andor, Yuichiro Ihara, Robin Lerner, Haiyun Gan, Xiaoyue Chen, Dong Fang, Xi Huang, Maxwell W Tom, Vy Ngo, David Solomon, Sabine Mueller, Pamela L Paris, Zhiguo Zhang, Claudia Petritsch, Nalin Gupta, Todd A Waldman, C David James

35) Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia (Nature Medicine) Monday November 17th 2014
Eduardo Gascon, Kelleen Lynch, Hongyu Ruan, Sandra Almeida, Jamie M Verheyden, William W Seeley, Dennis W Dickson, Leonard Petrucelli, Danqiong Sun, Jian Jiao, Hongru Zhou, Mira Jakovcevski, Schahram Akbarian, Wei-Dong Yao, Fen-Biao Gao

36) The brown fat (Nature Medicine) Monday November 17th 2014
Guo-Xiao Wang, Xu-Yun Zhao, Zhuo-Xian Meng, Matthias Kern, Arne Dietrich, Zhimin Chen, Zoharit Cozacov, Dequan Zhou, Adewole L Okunade, Xiong Su, Siming Li, Matthias Bl, Jiandie D Lin

37) Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes (Nature Medicine) Monday November 10th 2014
Menna R Clatworthy, Caren E Petrie Aronin, Rebeccah J Mathews, Nicole Y Morgan, Kenneth G C Smith, Ronald N Germain

38) Longitudinal PET-MRI reveals (Nature Medicine) Monday November 10th 2014
Florian C Maier, Hans F Wehrl, Andreas M Schmid, Julia G Mannheim, Stefan Wiehr, Chommanad Lerdkrai, Carsten Calaminus, Anke Stahlschmidt, Lan Ye, Michael Burnet, Detlef Stiller, Osama Sabri, Gerald Reischl, Mathias Staufenbiel, Olga Garaschuk, Mathias Jucker, Bernd J Pichler

39) Anchored multiplex PCR for targeted next-generation sequencing (Nature Medicine) Monday November 10th 2014
Zongli Zheng, Matthew Liebers, Boryana Zhelyazkova, Yi Cao, Divya Panditi, Kerry D Lynch, Juxiang Chen, Hayley E Robinson, Hyo Sup Shim, Juliann Chmielecki, William Pao, Jeffrey A Engelman, A John Iafrate, Long Phi Le

40) University travel bans and quarantines may impede Ebola response (Nature Medicine) Monday November 10th 2014
Cassandra Willyard

41) Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress (Nature Medicine) Sunday November 2nd 2014
Sumaira Z Hasnain, Danielle J Borg, Brooke E Harcourt, Hui Tong, Yonghua H Sheng, Choa Ping Ng, Indrajit Das, Ran Wang, Alice C-H Chen, Thomas Loudovaris, Thomas W Kay, Helen E Thomas, Jonathan P Whitehead, Josephine M Forbes, Johannes B Prins, Michael A McGuckin

42) An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease (Nature Medicine) Sunday November 2nd 2014
Ryosuke Kikuchi, Kazuto Nakamura, Susan MacLauchlan, Doan Thi-Minh Ngo, Ippei Shimizu, Jose Javier Fuster, Yasufumi Katanasaka, Sumiko Yoshida, Yan Qiu, Terry P Yamaguchi, Tadashi Matsushita, Toyoaki Murohara, Noyan Gokce, David O Bates, Naomi M Hamburg, Kenneth Walsh

43) A role for interleukin-22 in the alleviation of metabolic syndrome (Nature Medicine) Sunday November 2nd 2014
Elise Dalmas, Marc Y Donath

44) Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension (Nature Medicine) Sunday October 26th 2014
Rajkumar Savai, Hamza M Al-Tamari, Daniel Sedding, Baktybek Kojonazarov, Christian Muecke, Rebecca Teske, Mario R Capecchi, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti

45) Cancer cell (Nature Medicine) Sunday October 26th 2014
Antonella Sistigu, Takahiro Yamazaki, Erika Vacchelli, Kariman Chaba, David P Enot, Julien Adam, Ilio Vitale, Aicha Goubar, Elisa E Baracco, Catarina Rem, Laetitia Fend, Dalil Hannani, Laetitia Aymeric, Yuting Ma, Mireia Niso-Santano, Oliver Kepp, Joachim L Schultze, Thomas T, Filippo Belardelli, Laura Bracci, Valentina La Sorsa, Giovanna Ziccheddu, Paola Sestili, Francesca Urbani, Mauro Delorenzi, Magali Lacroix-Triki, Virginie Quidville, Rosa Conforti, Jean-Philippe Spano, Lajos Pusztai, Vichnou Poirier-Colame, Suzette Delaloge, Frederique Penault-Llorca, Sylvain Ladoire, Laurent Arnould, Joanna Cyrta, Marie-Charlotte Dessoliers, Alexander Eggermont, Marco E Bianchi, Mikael Pittet, Camilla Engblom, Christina Pfirschke, Xavier Pr, Gilles Uz, Robert D Schreiber, Melvyn T Chow, Mark J Smyth, Enrico Proietti, Fabrice Andr, Guido Kroemer, Laurence Zitvogel

46) Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging (Nature Medicine) Sunday October 26th 2014
Kenneth M Tichauer, Kimberley S Samkoe, Jason R Gunn, Stephen C Kanick, P Jack Hoopes, Richard J Barth, Peter A Kaufman, Tayyaba Hasan, Brian W Pogue

47) Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations (Nature Medicine) Monday October 20th 2014
Desir, Claudia Bode, Rupert Kenefeck, Tie Zheng Hou, James B Wing, Alan Kennedy, Alla Bulashevska, Britt-Sabina Petersen, Alejandro A Sch, Bj, Susanne Unger, Natalie Frede, Ulrich Baumann, Torsten Witte, Reinhold E Schmidt, Gregor Dueckers, Tim Niehues, Suranjith Seneviratne, Maria Kanariou, Carsten Speckmann, Stephan Ehl, Anne Rensing-Ehl, Klaus Warnatz, Mirzokhid Rakhmanov, Robert Thimme, Peter Hasselblatt, Florian Emmerich, Toni Cathomen, Rolf Backofen, Paul Fisch, Maximilian Seidl, Annette May, Annette Schmitt-Graeff, Shinji Ikemizu, Ulrich Salzer, Andre Franke, Shimon Sakaguchi, Lucy S K Walker, David M Sansom, Bodo Grimbacher

48) Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease (Nature Medicine) Sunday October 19th 2014
Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M Duong, Nicholas T Seyfried, William T Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Yi E Sun, Shan Ping Yu, Allan I Levey, Keqiang Ye

49) Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion (Nature Medicine) Sunday October 19th 2014
Ingmar Bruns, Daniel Lucas, Sandra Pinho, Jalal Ahmed, Michele P Lambert, Yuya Kunisaki, Christoph Scheiermann, Lauren Schiff, Mortimer Poncz, Aviv Bergman, Paul S Frenette

50) Regulatory B cells are induced by gut microbiota (Nature Medicine) Sunday October 19th 2014
Elizabeth C Rosser, Kristine Oleinika, Silvia Tonon, Ronan Doyle, Anneleen Bosma, Natalie A Carter, Kathryn A Harris, Simon A Jones, Nigel Klein, Claudia Mauri

51) An in vivo model of human small intestine using pluripotent stem cells (Nature Medicine) Sunday October 19th 2014
Carey L Watson, Maxime M Mahe, Jorge M, Jonathan C Howell, Nambirajan Sundaram, Holly M Poling, Jamie I Schweitzer, Jefferson E Vallance, Christopher N Mayhew, Ying Sun, Gregory Grabowski, Stacy R Finkbeiner, Jason R Spence, Noah F Shroyer, James M Wells, Michael A Helmrath

52) Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells (Nature Medicine) Sunday October 19th 2014
Meng Zhao, John M Perry, Heather Marshall, Aparna Venkatraman, Pengxu Qian, Xi C He, Jasimuddin Ahamed, Linheng Li

53) A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer (Nature Medicine) Sunday October 19th 2014
Nina Sch, Barbara Seidler, Kathleen Schuck, Christian Veltkamp, Christina Schachtler, Magdalena Zukowska, Stefan Eser, Thorsten B Feyerabend, Mariel C Paul, Philipp Eser, Sabine Klein, Andrew M Lowy, Ruby Banerjee, Fangtang Yang, Chang-Lung Lee, Everett J Moding, David G Kirsch, Angelika Scheideler, Dario R Alessi, Ignacio Varela, Allan Bradley, Alexander Kind, Angelika E Schnieke, Hans-Reimer Rodewald, Roland Rad, Roland M Schmid, G, Dieter Saur

54) Age-related mutations associated with clonal hematopoietic expansion and malignancies (Nature Medicine) Sunday October 19th 2014
Mingchao Xie, Charles Lu, Jiayin Wang, Michael D McLellan, Kimberly J Johnson, Michael C Wendl, Joshua F McMichael, Heather K Schmidt, Venkata Yellapantula, Christopher A Miller, Bradley A Ozenberger, John S Welch, Daniel C Link, Matthew J Walter, Elaine R Mardis, John F Dipersio, Feng Chen, Richard K Wilson, Timothy J Ley, Li Ding

55) Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures (Nature Medicine) Sunday October 12th 2014
Sofia Mov, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E B, Klara Sj, Sara H Windahl, Helen Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars S, Jian Q Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H Lerner, Francesca Gori, Claes Ohlsson

56) Niclosamide ethanolamine (Nature Medicine) Sunday October 5th 2014
Hanlin Tao, Yong Zhang, Xiangang Zeng, Gerald I Shulman, Shengkan Jin

57) PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis (Nature Medicine) Sunday October 5th 2014
Hui Xie, Zhuang Cui, Long Wang, Zhuying Xia, Yin Hu, Lingling Xian, Changjun Li, Liang Xie, Janet Crane, Mei Wan, Gehua Zhen, Qin Bian, Bin Yu, Weizhong Chang, Tao Qiu, Maureen Pickarski, Le Thi Duong, Jolene J Windle, Xianghang Luo, Eryuan Liao, Xu Cao

58) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells (Nature Medicine) Sunday October 5th 2014
Luciana Berod, Christin Friedrich, Amrita Nandan, Jenny Freitag, Stefanie Hagemann, Kirsten Harmrolfs, Aline Sandouk, Christina Hesse, Carla N Castro, Heike B, Sarah K Tschirner, Nataliya Gorinski, Melanie Gohmert, Christian T Mayer, Jochen Huehn, Evgeni Ponimaskin, Wolf-Rainer Abraham, Rolf M, Matthias Lochner, Tim Sparwasser

59) Progranulin protects against amyloid (Nature Medicine) Sunday September 28th 2014
S Sakura Minami, Sang-Won Min, Grietje Krabbe, Chao Wang, Yungui Zhou, Rustam Asgarov, Yaqiao Li, Lauren H Martens, Lisa P Elia, Michael E Ward, Lennart Mucke, Robert V Farese, Li Gan

60) Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development (Nature Medicine) Sunday September 28th 2014
Jared R Mayers, Chen Wu, Clary B Clish, Peter Kraft, Margaret E Torrence, Brian P Fiske, Chen Yuan, Ying Bao, Mary K Townsend, Shelley S Tworoger, Shawn M Davidson, Thales Papagiannakopoulos, Annan Yang, Talya L Dayton, Shuji Ogino, Meir J Stampfer, Edward L Giovannucci, Zhi Rong Qian, Douglas A Rubinson, Jing Ma, Howard D Sesso, John M Gaziano, Barbara B Cochrane, Simin Liu, Jean Wactawski-Wende, JoAnn E Manson, Michael N Pollak, Alec C Kimmelman, Amanda Souza, Kerry Pierce, Thomas J Wang, Robert E Gerszten, Charles S Fuchs, Matthew G Vander Heiden, Brian M Wolpin

61) Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants (Nature Medicine) Monday September 22nd 2014
Deena Gibbons, Paul Fleming, Alex Virasami, Marie-Laure Michel, Neil J Sebire, Kate Costeloe, Robert Carr, Nigel Klein, Adrian Hayday

62) Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis (Nature Medicine) Friday September 12th 2014
Jean-S, Satra Nim, Tang Zhu, Nicholas Sitaras, Jos, Zhuo Shao, Przemyslaw Sapieha, David Hamel, Melanie Sanchez, Karine Zaniolo, Manon St-Louis, Johanne Ouellette, Martin Montoya-Zavala, Alexandra Zabeida, Emilie Picard, Pierre Hardy, Vikrant Bhosle, Daya R Varma, Fernand Gobeil, Christian Beaus, Christelle Boileau, William Klein, Morley Hollenberg, Alfredo Ribeiro-da-Silva, Gregor Andelfinger, Sylvain Chemtob

63) Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation (Nature Medicine) Friday September 12th 2014
Lior Mayo, Sunia A Trauger, Manon Blain, Meghan Nadeau, Bonny Patel, Jorge I Alvarez, Ivan D Mascanfroni, Ada Yeste, Pia Kivis, Keith Kallas, Benjamin Ellezam, Rohit Bakshi, Alexandre Prat, Jack P Antel, Howard L Weiner, Francisco J Quintana

64) In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer (Nature Medicine) Friday September 12th 2014
Ramona Rudalska, Daniel Dauch, Thomas Longerich, Katherine McJunkin, Torsten Wuestefeld, Tae-Won Kang, Anja Hohmeyer, Marina Pesic, Josef Leibold, Anne von Thun, Peter Schirmacher, Johannes Zuber, Karl-Heinz Weiss, Scott Powers, Nisar P Malek, Martin Eilers, Bence Sipos, Scott W Lowe, Robert Geffers, Stefan Laufer, Lars Zender

65) The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy (Nature Medicine) Friday September 12th 2014
Xiping Cheng, Xiaoli Zhang, Qiong Gao, Mohammad Ali Samie, Marlene Azar, Wai Lok Tsang, Libing Dong, Nirakar Sahoo, Xinran Li, Yue Zhuo, Abigail G Garrity, Xiang Wang, Marc Ferrer, James Dowling, Li Xu, Renzhi Han, Haoxing Xu

66) An extracorporeal blood-cleansing device for sepsis therapy (Nature Medicine) Friday September 12th 2014
Joo H Kang, Michael Super, Chong Wing Yung, Ryan M Cooper, Karel Domansky, Amanda R Graveline, Tadanori Mammoto, Julia B Berthet, Heather Tobin, Mark J Cartwright, Alexander L Watters, Martin Rottman, Anna Waterhouse, Akiko Mammoto, Nazita Gamini, Melissa J Rodas, Anxhela Kole, Amanda Jiang, Thomas M Valentin, Alexander Diaz, Kazue Takahashi, Donald E Ingber

67) Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge (Nature Medicine) Sunday September 7th 2014
Daphne A Stanley, Anna N Honko, Clement Asiedu, John C Trefry, Annie W Lau-Kilby, Joshua C Johnson, Lisa Hensley, Virginia Ammendola, Adele Abbate, Fabiana Grazioli, Kathryn E Foulds, Cheng Cheng, Lingshu Wang, Mitzi M Donaldson, Stefano Colloca, Antonella Folgori, Mario Roederer, Gary J Nabel, John Mascola, Alfredo Nicosia, Riccardo Cortese, Richard A Koup, Nancy J Sullivan

68) A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia (Nature Medicine) Sunday September 7th 2014
Daniel Herranz, Alberto Ambesi-Impiombato, Teresa Palomero, Stephanie A Schnell, Laura Belver, Agnieszka A Wendorff, Luyao Xu, Mireia Castillo-Martin, David Llobet-Nav, Carlos Cordon-Cardo, Emmanuelle Clappier, Jean Soulier, Adolfo A Ferrando

69) Inhibition of JAK-STAT signaling stimulates adult satellite cell function (Nature Medicine) Sunday September 7th 2014
Feodor D Price, Julia von Maltzahn, C Florian Bentzinger, Nicolas A Dumont, Hang Yin, Natasha C Chang, David H Wilson, J, Michael A Rudnicki

70) A new tumor suppressor role for the Notch pathway in bladder cancer (Nature Medicine) Sunday September 7th 2014
Theodoros Rampias, Paraskevi Vgenopoulou, Margaritis Avgeris, Alexander Polyzos, Konstantinos Stravodimos, Christos Valavanis, Andreas Scorilas, Apostolos Klinakis

71) STAT3 signaling controls satellite cell expansion and skeletal muscle repair (Nature Medicine) Sunday September 7th 2014
Matthew Timothy Tierney, Tufan Aydogdu, David Sala, Barbora Malecova, Sole Gatto, Pier Lorenzo Puri, Lucia Latella, Alessandra Sacco

72) Rationale for co-targeting IGF-1R and ALK in ALK fusion (Nature Medicine) Sunday August 31st 2014
Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozreti, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ans, Sven Perner, Michael Brockmann, Marc Bos, J, Masyar Gardizi, Gavin M Wright, Benjamin Solomon, Prudence A Russell, Toni-Maree Rogers, Yoshiyuki Suehara, Monica Red-Brewer, Rudy Tieu, Elisa de Stanchina, Qingguo Wang, Zhongming Zhao, David H Johnson, Leora Horn, Kwok-Kin Wong, Roman K Thomas, Marc Ladanyi, William Pao

73) Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis (Nature Medicine) Sunday August 31st 2014
Weng Kung Peng, Tian Fook Kong, Chee Sheng Ng, Lan Chen, Yongxue Huang, Ali Asgar S Bhagat, Nam-Trung Nguyen, Peter Rainer Preiser, Jongyoon Han

74) The G protein (Nature Medicine) Sunday August 24th 2014
Xuelian He, Liguo Zhang, Ying Chen, Marc Remke, David Shih, Fanghui Lu, Haibo Wang, Yaqi Deng, Yang Yu, Yong Xia, Xiaochong Wu, Vijay Ramaswamy, Tom Hu, Fan Wang, Wenhao Zhou, Dennis K Burns, Se Hoon Kim, Marcel Kool, Stefan M Pfister, Lee S Weinstein, Scott L Pomeroy, Richard J Gilbertson, Joshua B Rubin, Yiping Hou, Robert Wechsler-Reya, Michael D Taylor, Q Richard Lu

75) Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A (Nature Medicine) Sunday August 24th 2014
Robert Fledrich, Ruth M Stassart, Axel Klink, Lennart M Rasch, Thomas Prukop, Lauren Haag, Dirk Czesnik, Theresa Kungl, Tamer A M Abdelaal, Naureen Keric, Christine Stadelmann, Wolfgang Br, Klaus-Armin Nave, Michael W Sereda

76) An implantable microfluidic device for self-monitoring of intraocular pressure (Nature Medicine) Sunday August 24th 2014
Ismail E Araci, Baolong Su, Stephen R Quake, Yossi Mandel

77) Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition (Nature Medicine) Sunday August 17th 2014
Luzhou Xing, Zhenpeng Dai, Ali Jabbari, Jane E Cerise, Claire A Higgins, Weijuan Gong, Annemieke de Jong, Sivan Harel, Gina M DeStefano, Lisa Rothman, Pallavi Singh, Lynn Petukhova, Julian Mackay-Wiggan, Angela M Christiano, Raphael Clynes

78) CAPON-nNOS coupling can serve as a target for developing new anxiolytics (Nature Medicine) Sunday August 17th 2014
Li-Juan Zhu, Ting-You Li, Chun-Xia Luo, Nan Jiang, Lei Chang, Yu-Hui Lin, Hai-Hui Zhou, Chen Chen, Yu Zhang, Wei Lu, Li-Yan Gao, Yu Ma, Qi-Gang Zhou, Qin Hu, Xiao-Ling Hu, Jing Zhang, Hai-Yin Wu, Dong-Ya Zhu

79) In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors (Nature Medicine) Sunday August 17th 2014
Phil Oh, Jacqueline E Testa, Per Borgstrom, Halina Witkiewicz, Yan Li, Jan E Schnitzer

80) Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice (Nature Medicine) Sunday August 10th 2014
Nicolas Wein, Adeline Vulin, Maria S Falzarano, Christina Al-Khalili Szigyarto, Baijayanta Maiti, Andrew Findlay, Kristin N Heller, Mathias Uhl, Baskar Bakthavachalu, Sonia Messina, Giuseppe Vita, Chiara Passarelli, Francesca Gualandi, Steve D Wilton, Louise R Rodino-Klapac, Lin Yang, Diane M Dunn, Daniel R Schoenberg, Robert B Weiss, Michael T Howard, Alessandra Ferlini, Kevin M Flanigan

81) An acetate switch regulates stress erythropoiesis (Nature Medicine) Sunday August 10th 2014
Min Xu, Jason S Nagati, Jian Xie, Jiwen Li, Holly Walters, Young-Ah Moon, Robert D Gerard, Chou-Long Huang, Sarah A Comerford, Robert E Hammer, Jay D Horton, Rui Chen, Joseph A Garcia

82) Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor- (Nature Medicine) Sunday August 10th 2014
Bo Yu, Jia Chang, Yunsong Liu, Jiong Li, Kareena Kevork, Khalid Al-Hezaimi, Dana T Graves, No-Hee Park, Cun-Yu Wang

83) Obesity- and aging-induced excess of central transforming growth factor- (Nature Medicine) Sunday August 3rd 2014
Jingqi Yan, Hai Zhang, Ye Yin, Juxue Li, Yizhe Tang, Sudarshana Purkayastha, Lianxi Li, Dongsheng Cai

84) An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action (Nature Medicine) Monday July 28th 2014
Julie Gibbs, Louise Ince, Laura Matthews, Junjie Mei, Thomas Bell, Nan Yang, Ben Saer, Nicola Begley, Toryn Poolman, Marie Pariollaud, Stuart Farrow, Francesco DeMayo, Tracy Hussell, G Scott Worthen, David Ray, Andrew Loudon

85) Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation (Nature Medicine) Monday July 28th 2014
Daisuke Yamane, David R McGivern, Eliane Wauthier, MinKyung Yi, Victoria J Madden, Christoph Welsch, Iris Antes, Yahong Wen, Pauline E Chugh, Charles E McGee, Douglas G Widman, Ichiro Misumi, Sibali Bandyopadhyay, Seungtaek Kim, Tetsuro Shimakami, Tsunekazu Oikawa, Jason K Whitmire, Mark T Heise, Dirk P Dittmer, C Cheng Kao, Stuart M Pitson, Alfred H Merrill, Lola M Reid, Stanley M Lemon

86) Intracellular calcium regulates nonsense-mediated mRNA decay (Nature Medicine) Monday July 28th 2014
Andrew Nickless, Erin Jackson, Jayne Marasa, Patrick Nugent, Robert W Mercer, David Piwnica-Worms, Zhongsheng You

87) Huntington's disease is a four-repeat tauopathy with tau nuclear rods (Nature Medicine) Sunday July 20th 2014
Marta Fern, Jorge R Cabrera, Mar, Jeroen J M Hoozemans, Isidro Ferrer, Annemieke J M Rozemuller, F, Jes, Jos

88) Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity (Nature Medicine) Sunday July 20th 2014
Pengpeng Bi, Tizhong Shan, Weiyi Liu, Feng Yue, Xin Yang, Xin-Rong Liang, Jinghua Wang, Jie Li, Nadia Carlesso, Xiaoqi Liu, Shihuan Kuang

89) The ribonuclease activity of SAMHD1 is required for HIV-1 restriction (Nature Medicine) Sunday July 20th 2014
Jeongmin Ryoo, Jongsu Choi, Changhoon Oh, Sungchul Kim, Minji Seo, Seok-Young Kim, Daekwan Seo, Jongkyu Kim, Tommy E White, Alberto Brandariz-Nu, Felipe Diaz-Griffero, Cheol-Heui Yun, Joseph A Hollenbaugh, Baek Kim, Daehyun Baek, Kwangseog Ahn

90) Asfotase- (Nature Medicine) Sunday July 13th 2014
Jean de la Croix Ndong, Alexander J Makowski, Sasidhar Uppuganti, Guillaume Vignaux, Koichiro Ono, Daniel S Perrien, Simon Joubert, Serena R Baglio, Donatella Granchi, David A Stevenson, Jonathan J Rios, Jeffry S Nyman, Florent Elefteriou

91) GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease (Nature Medicine) Sunday July 13th 2014
Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-Jin Oh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim, C Justin Lee

92) A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice (Nature Medicine) Sunday July 13th 2014
Da Young Oh, Evelyn Walenta, Taro E Akiyama, William S Lagakos, Denise Lackey, Ariane R Pessentheiner, Roman Sasik, Nasun Hah, Tyler J Chi, Jason M Cox, Mary Ann Powels, Jerry Di Salvo, Christopher Sinz, Steven M Watkins, Aaron M Armando, Heekyung Chung, Ronald M Evans, Oswald Quehenberger, Joanne McNelis, Juliane G Bogner-Strauss, Jerrold M Olefsky

93) A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes (Nature Medicine) Sunday July 13th 2014
Bo Zhang, Rajiv B Kumar, Hongjie Dai, Brian J Feldman

94) Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis (Nature Medicine) Sunday July 13th 2014
Feng Mei, Stephen P J Fancy, Yun-An A Shen, Jianqin Niu, Chao Zhao, Bryan Presley, Edna Miao, Seonok Lee, Sonia R Mayoral, Stephanie A Redmond, Ainhoa Etxeberria, Lan Xiao, Robin J M Franklin, Ari Green, Stephen L Hauser, Jonah R Chan

95) Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition (Nature Medicine) Sunday June 29th 2014
Yujie Tang, Sharareh Gholamin, Simone Schubert, Minde I Willardson, Alex Lee, Pratiti Bandopadhayay, Guillame Bergthold, Sabran Masoud, Brian Nguyen, Nujsaubnusi Vue, Brianna Balansay, Furong Yu, Sekyung Oh, Pamelyn Woo, Spenser Chen, Anitha Ponnuswami, Michelle Monje, Scott X Atwood, Ramon J Whitson, Siddhartha Mitra, Samuel H Cheshier, Jun Qi, Rameen Beroukhim, Jean Y Tang, Rob Wechsler-Reya, Anthony E Oro, Brian A Link, James E Bradner, Yoon-Jae Cho

96) Chronic variable stress activates hematopoietic stem cells (Nature Medicine) Sunday June 29th 2014
Timo Heidt, Hendrik B Sager, Gabriel Courties, Partha Dutta, Yoshiko Iwamoto, Alex Zaltsman, Constantin von zur Muhlen, Christoph Bode, Gregory L Fricchione, John Denninger, Charles P Lin, Claudio Vinegoni, Peter Libby, Filip K Swirski, Ralph Weissleder, Matthias Nahrendorf

97) Altered translation of GATA1 in Diamond-Blackfan anemia (Nature Medicine) Sunday June 29th 2014
Leif S Ludwig, Hanna T Gazda, Jennifer C Eng, Stephen W Eichhorn, Prathapan Thiru, Roxanne Ghazvinian, Tracy I George, Jason R Gotlib, Alan H Beggs, Colin A Sieff, Harvey F Lodish, Eric S Lander, Vijay G Sankaran

98) Supercooling enables long-term transplantation survival following 4 days of liver preservation (Nature Medicine) Sunday June 29th 2014
Tim A Berendsen, Bote G Bruinsma, Catheleyne F Puts, Nima Saeidi, O Berk Usta, Basak E Uygun, Maria-Louisa Izamis, Mehmet Toner, Martin L Yarmush, Korkut Uygun

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