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1) Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII (Nature Chemical Biology) Sunday May 13th 2012
Wojciech Jankowski, Tamjeed Saleh, Ming-Tao Pai, Ganapathy Sriram, Raymond B Birge, Charalampos G Kalodimos

2) Fluorescent castasterone reveals BRI1 signaling from the plasma membrane (Nature Chemical Biology) Monday May 7th 2012
Niloufer G Irani, Simone Di Rubbo, Evelien Mylle, Jos Van den Begin, Joanna Schneider-Pizoń, Jaroslava Hniliková, Miroslav Šíša, Dieter Buyst, Josep Vilarrasa-Blasi, Anna-Mária Szatmári, Daniël Van Damme, Kiril Mishev, Mirela-Corina Codreanu, Ladislav Kohout, Miroslav Strnad, Ana I Caño-Delgado, Jiří Friml, Annemieke Madder, Eugenia Russinova

3) YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations (Nature Chemical Biology) Sunday April 22nd 2012
Kyle L Dunbar, Joel O Melby, Douglas A Mitchell

4) Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase (Nature Chemical Biology) Sunday April 22nd 2012
Yi-Fan Xu, Daniel Amador-Noguez, Marshall Louis Reaves, Xiao-Jiang Feng, Joshua D Rabinowitz

5) Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing (Nature Chemical Biology) Sunday April 15th 2012
Frank Rigo, Yimin Hua, Seung J Chun, Thazha P Prakash, Adrian R Krainer, C Frank Bennett

6) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling (Nature Chemical Biology) Sunday April 15th 2012
Mathew Sajish, Quansheng Zhou, Shuji Kishi, Delgado M Valdez, Mili Kapoor, Min Guo, Sunhee Lee, Sunghoon Kim, Xiang-Lei Yang, Paul Schimmel

7) Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells (Nature Chemical Biology) Sunday April 8th 2012
Chuan-Xu Liu, Qian-Qian Yin, Hu-Chen Zhou, Ying-Li Wu, Jian-Xin Pu, Li Xia, Wei Liu, Xin Huang, Tao Jiang, Ming-Xuan Wu, Li-Cai He, Ya-Xue Zhao, Xiao-Lin Wang, Wei-Lie Xiao, Hong-Zhuan Chen, Qian Zhao, Ai-Wu Zhou, Li-Shun Wang, Han-Dong Sun, Guo-Qiang Chen

8) A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin (Nature Chemical Biology) Sunday April 1st 2012
Luz Irina A Calderón Villalobos, Sarah Lee, Cesar De Oliveira, Anthony Ivetac, Wolfgang Brandt, Lynne Armitage, Laura B Sheard, Xu Tan, Geraint Parry, Haibin Mao, Ning Zheng, Richard Napier, Stefan Kepinski, Mark Estelle

9) Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles (Nature Chemical Biology) Sunday April 1st 2012
Iana M Serafimova, Miles A Pufall, Shyam Krishnan, Katarzyna Duda, Michael S Cohen, Rebecca L Maglathlin, Jesse M McFarland, Rand M Miller, Morten Frödin, Jack Taunton

10) An engineered eukaryotic protein glycosylation pathway in Escherichia coli (Nature Chemical Biology) Sunday March 25th 2012
Juan D Valderrama-Rincon, Adam C Fisher, Judith H Merritt, Yao-Yun Fan, Craig A Reading, Krishan Chhiba, Christian Heiss, Parastoo Azadi, Markus Aebi, Matthew P DeLisa

11) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system (Nature Chemical Biology) Sunday March 25th 2012
Takafumi Miyamoto, Robert DeRose, Allison Suarez, Tasuku Ueno, Melinda Chen, Tai-ping Sun, Michael J Wolfgang, Chandrani Mukherjee, David J Meyers, Takanari Inoue

12) Rationally designed families of orthogonal RNA regulators of translation (Nature Chemical Biology) Sunday March 25th 2012
Vivek K Mutalik, Lei Qi, Joao C Guimaraes, Julius B Lucks, Adam P Arkin

13) Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands (Nature Chemical Biology) Sunday March 25th 2012
Lars Richter, Chris de Graaf, Werner Sieghart, Zdravko Varagic, Martina Mörzinger, Iwan J P de Esch, Gerhard F Ecker, Margot Ernst

14) Programmable enantioselective one-pot synthesis of molecules with eight stereocenters (Nature Chemical Biology) Sunday March 18th 2012
Marco Potowski, Markus Schürmann, Hans Preut, Andrey P Antonchick, Herbert Waldmann

15) Signaling-mediated bacterial persister formation (Nature Chemical Biology) Sunday March 18th 2012
Nicole M Vega, Kyle R Allison, Ahmad S Khalil, James J Collins

16) LYP inhibits T-cell activation when dissociated from CSK (Nature Chemical Biology) Sunday March 18th 2012
Torkel Vang, Wallace H Liu, Laurence Delacroix, Shuangding Wu, Stefan Vasile, Russell Dahl, Li Yang, Lucia Musumeci, Dana Francis, Johannes Landskron, Kjetil Tasken, Michel L Tremblay, Benedicte A Lie, Rebecca Page, Tomas Mustelin, Souad Rahmouni, Robert C Rickert, Lutz Tautz

17) A fungal ketoreductase domain that displays substrate-dependent stereospecificity (Nature Chemical Biology) Sunday March 11th 2012
Hui Zhou, Zhizeng Gao, Kangjian Qiao, Jingjing Wang, John C Vederas, Yi Tang

18) A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion (Nature Chemical Biology) Sunday March 11th 2012
Felix Kopp, Christopher F Stratton, Lakshmi B Akella, Derek S Tan

19) Peptides induce persistent signaling from endosomes by a nutrient transceptor (Nature Chemical Biology) Sunday March 4th 2012
Marta Rubio-Texeira, Griet Van Zeebroeck, Johan M Thevelein

20) The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A (Nature Chemical Biology) Sunday February 26th 2012
Leif Flühe, Thomas A Knappe, Michael J Gattner, Antje Schäfer, Olaf Burghaus, Uwe Linne, Mohamed A Marahiel

21) Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP (Nature Chemical Biology) Sunday February 26th 2012
Vedangi Sample, Lisa M DiPilato, Jason H Yang, Qiang Ni, Jeffrey J Saucerman, Jin Zhang

22) Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation (Nature Chemical Biology) Sunday February 26th 2012
Scott A Yuzwa, Xiaoyang Shan, Matthew S Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J Vocadlo

23) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination (Nature Chemical Biology) Sunday February 26th 2012
Xing Zeng, Randall W King

24) Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles (Nature Chemical Biology) Sunday February 19th 2012
George Georghiou, Ralph E Kleiner, Michael Pulkoski-Gross, David R Liu, Markus A Seeliger

25) Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane (Nature Chemical Biology) Sunday February 19th 2012
Anna E Grzegorzewicz, Ha Pham, Vijay A K B Gundi, Michael S Scherman, Elton J North, Tamara Hess, Victoria Jones, Veronica Gruppo, Sarah E M Born, Jana Korduláková, Sivagami Sundaram Chavadi, Christophe Morisseau, Anne J Lenaerts, Richard E Lee, Michael R McNeil, Mary Jackson

26) Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein (Nature Chemical Biology) Sunday February 19th 2012
Lei Zhang, Feng Yan, Shengli Zhang, Dongsheng Lei, M Arthur Charles, Giorgio Cavigiolio, Michael Oda, Ronald M Krauss, Karl H Weisgraber, Kerry-Anne Rye, Henry J Pownall, Xiayang Qiu, Gang Ren

27) Using transcriptome sequencing to identify mechanisms of drug action and resistance (Nature Chemical Biology) Sunday February 12th 2012
Sarah A Wacker, Benjamin R Houghtaling, Olivier Elemento, Tarun M Kapoor

28) Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA (Nature Chemical Biology) Sunday February 12th 2012
Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Qing Dai, Guo-Liang Xu, Cheng Luo, Hualiang Jiang, Chuan He

29) Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase (Nature Chemical Biology) Sunday February 12th 2012
Tracy L Keller, Davide Zocco, Mark S Sundrud, Margaret Hendrick, Maja Edenius, Jinah Yum, Yeon-Jin Kim, Hak-Kyo Lee, Joseph F Cortese, Dyann F Wirth, John David Dignam, Anjana Rao, Chang-Yeol Yeo, Ralph Mazitschek, Malcolm Whitman

30) Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis (Nature Chemical Biology) Sunday February 5th 2012
Sagar D Khare, Yakov Kipnis, Per Jr Greisen, Ryo Takeuchi, Yacov Ashani, Moshe Goldsmith, Yifan Song, Jasmine L Gallaher, Israel Silman, Haim Leader, Joel L Sussman, Barry L Stoddard, Dan S Tawfik, David Baker

31) Small-molecule–induced DNA damage identifies alternative DNA structures in human genes (Nature Chemical Biology) Sunday February 5th 2012
Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan, Sébastien Britton, Tobias Oelschlaegel, Blerta Xhemalce, Shankar Balasubramanian, Stephen P Jackson

32) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia (Nature Chemical Biology) Sunday January 29th 2012
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G Muntean, Roderick J Sorenson, Hollis D Showalter, Marcelo J Murai, Amalia M Belcher, Thomas Hartley, Jay L Hess, Tomasz Cierpicki

33) BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia (Nature Chemical Biology) Sunday January 29th 2012
Oliver Hantschel, Wolfgang Warsch, Eva Eckelhart, Ines Kaupe, Florian Grebien, Kay-Uwe Wagner, Giulio Superti-Furga, Veronika Sexl

34) Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development (Nature Chemical Biology) Sunday January 29th 2012
Ilya A Shestopalov, Cameron L W Pitt, James K Chen

35) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin (Nature Chemical Biology) Monday January 23rd 2012
Gary J. Patti, Oscar Yanes, Leah P Shriver, Jean-Phillipe Courade, Ralf Tautenhahn, Marianne Manchester, Gary Siuzdak

36) Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation (Nature Chemical Biology) Monday January 23rd 2012
Jessica E Rexach, Peter M Clark, Daniel E Mason, Rachael L Neve, Eric C Peters, Linda C Hsieh-Wilson

37) Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis (Nature Chemical Biology) Monday January 23rd 2012
Mary Katherine Tarrant, Hee-Sool Rho, Zhi Xie, Yu Lin Jiang, Christopher Gross, Jeffrey C Culhane, Gai Yan, Jiang Qian, Yoshitaka Ichikawa, Tatsuji Matsuoka, Natasha Zachara, Felicia A Etzkorn, Gerald W Hart, Jun Seop Jeong, Seth Blackshaw, Heng Zhu, Philip A Cole

38) Chemical chaperones assist intracellular folding to buffer mutational variations (Nature Chemical Biology) Sunday January 15th 2012
Anannya Bandyopadhyay, Kanika Saxena, Neha Kasturia, Vijit Dalal, Niraj Bhatt, Asher Rajkumar, Shuvadeep Maity, Shantanu Sengupta, Kausik Chakraborty

39) Evidence for dynamics in proteins as a mechanism for ligand dissociation (Nature Chemical Biology) Sunday January 15th 2012
Mary J Carroll, Randall V Mauldin, Anna V Gromova, Scott F Singleton, Edward J Collins, Andrew L Lee

40) Disease-specific non–reducing end carbohydrate biomarkers for mucopolysaccharidoses (Nature Chemical Biology) Monday January 9th 2012
Roger Lawrence, Jillian R Brown, Kanar Al-Mafraji, William C Lamanna, James R Beitel, Geert-Jan Boons, Jeffrey D Esko, Brett E Crawford

41) Oxysterols are allosteric activators of the oncoprotein Smoothened (Nature Chemical Biology) Monday January 9th 2012
Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey, Rajat Rohatgi

42) Timing facilitated site transfer of an enzyme on DNA (Nature Chemical Biology) Monday January 9th 2012
Joseph D Schonhoft, James T Stivers

43) Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor (Nature Chemical Biology) Sunday December 25th 2011
Solveigh C Koeberle, Johannes Romir, Stefan Fischer, Andreas Koeberle, Verena Schattel, Wolfgang Albrecht, Christian Grütter, Oliver Werz, Daniel Rauh, Thilo Stehle, Stefan A Laufer

44) Small-molecule proteostasis regulators for protein conformational diseases (Nature Chemical Biology) Sunday December 25th 2011
Barbara Calamini, Maria Catarina Silva, Franck Madoux, Darren M Hutt, Shilpi Khanna, Monica A Chalfant, S Adrian Saldanha, Peter Hodder, Bradley D Tait, Dan Garza, William E Balch, Richard I Morimoto

45) Natural product–inspired cascade synthesis yields modulators of centrosome integrity (Nature Chemical Biology) Sunday December 25th 2011
Heiko Dückert, Verena Pries, Vivek Khedkar, Sascha Menninger, Hanna Bruss, Alexander W Bird, Zoltan Maliga, Andreas Brockmeyer, Petra Janning, Anthony Hyman, Stefan Grimme, Markus Schürmann, Hans Preut, Katja Hübel, Slava Ziegler, Kamal Kumar, Herbert Waldmann

46) Primary amines protect against retinal degeneration in mouse models of retinopathies (Nature Chemical Biology) Sunday December 25th 2011
Akiko Maeda, Marcin Golczak, Yu Chen, Kiichiro Okano, Hideo Kohno, Satomi Shiose, Kaede Ishikawa, William Harte, Grazyna Palczewska, Tadao Maeda, Krzysztof Palczewski

47) Chemical informatics and target identification in a zebrafish phenotypic screen (Nature Chemical Biology) Sunday December 18th 2011
Christian Laggner, David Kokel, Vincent Setola, Alexandra Tolia, Henry Lin, John J Irwin, Michael J Keiser, Chung Yan J Cheung, Daniel L Minor, Bryan L Roth, Randall T Peterson, Brian K Shoichet

48) A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis (Nature Chemical Biology) Sunday December 18th 2011
Tom Bretschneider, Georg Zocher, Michelle Unger, Kirstin Scherlach, Thilo Stehle, Christian Hertweck

49) How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels (Nature Chemical Biology) Sunday December 18th 2011
Jana Kusch, Susanne Thon, Eckhard Schulz, Christoph Biskup, Vasilica Nache, Thomas Zimmer, Reinhard Seifert, Frank Schwede, Klaus Benndorf

50) Knot formation in newly translated proteins is spontaneous and accelerated by chaperonins (Nature Chemical Biology) Sunday December 18th 2011
Anna L Mallam, Sophie E Jackson

51) Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity (Nature Chemical Biology) Sunday December 11th 2011
Candice E Paulsen, Thu H Truong, Francisco J Garcia, Arne Homann, Vinayak Gupta, Stephen E Leonard, Kate S Carroll

52) Unusual carbon fixation gives rise to diverse polyketide extender units (Nature Chemical Biology) Sunday December 4th 2011
Nick Quade, Liujie Huo, Shwan Rachid, Dirk W Heinz, Rolf Müller

53) Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes (Nature Chemical Biology) Sunday November 27th 2011
Daili J A Netz, Carrie M Stith, Martin Stümpfig, Gabriele Köpf, Daniel Vogel, Heide M Genau, Joseph L Stodola, Roland Lill, Peter M J Burgers, Antonio J Pierik

54) Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding (Nature Chemical Biology) Sunday November 27th 2011
Huanchen Wang, J R Falck, Traci M Tanaka Hall, Stephen B Shears

55) Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils (Nature Chemical Biology) Sunday November 20th 2011
Jan Bieschke, Martin Herbst, Thomas Wiglenda, Ralf P Friedrich, Annett Boeddrich, Franziska Schiele, Daniela Kleckers, Juan Miguel Lopez del Amo, Björn A Grüning, Qinwen Wang, Michael R Schmidt, Rudi Lurz, Roger Anwyl, Sigrid Schnoegl, Marcus Fändrich, Ronald F Frank, Bernd Reif, Stefan Günther, Dominic M Walsh, Erich E Wanker

56) Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site (Nature Chemical Biology) Sunday November 20th 2011
Andrés Nieto-Posadas, Giovanni Picazo-Juárez, Itzel Llorente, Andrés Jara-Oseguera, Sara Morales-Lázaro, Diana Escalante-Alcalde, León D Islas, Tamara Rosenbaum

57) FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy (Nature Chemical Biology) Sunday November 20th 2011
Aline M Santos, Deborah Schechtman, Alisson C Cardoso, Carolina F M Z Clemente, Júlio C Silva, Mariana Fioramonte, Michelle B M Pereira, Talita M Marin, Paulo S L Oliveira, Ana Carolina M Figueira, Saulo H P Oliveira, Íris L Torriani, Fábio C Gozzo, José Xavier Neto, Kleber G Franchini

58) Mechanical modulation of catalytic power on F1-ATPase (Nature Chemical Biology) Sunday November 20th 2011
Rikiya Watanabe, Daichi Okuno, Shouichi Sakakihara, Katsuya Shimabukuro, Ryota Iino, Masasuke Yoshida, Hiroyuki Noji

59) Deciphering the transcriptional regulatory logic of amino acid metabolism (Nature Chemical Biology) Monday November 14th 2011
Byung-Kwan Cho, Stephen Federowicz, Young-Seoub Park, Karsten Zengler, Bernhard Ø Palsson

60) A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase (Nature Chemical Biology) Monday November 14th 2011
Jiaoyang Jiang, Michael B Lazarus, Lincoln Pasquina, Piotr Sliz, Suzanne Walker

61) Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans (Nature Chemical Biology) Sunday November 6th 2011
Genna M Luciani, Lilia Magomedova, Rachel Puckrin, Malene L Urbanus, Iain M Wallace, Guri Giaever, Corey Nislow, Carolyn L Cummins, Peter J Roy

62) Structural basis of p38α regulation by hematopoietic tyrosine phosphatase (Nature Chemical Biology) Sunday November 6th 2011
Dana M Francis, Bartosz Różycki, Dorothy Koveal, Gerhard Hummer, Rebecca Page, Wolfgang Peti

63) Identifying polyglutamine protein species in situ that best predict neurodegeneration (Nature Chemical Biology) Sunday October 30th 2011
Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A Shaby, Gregor P Lotz, Yvonne Newhouse, Emily J Mitchell, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frédéric Saudou, Mark Segal, X William Yang, Eliezer Masliah, Leslie M Thompson, Paul J Muchowski, Karl H Weisgraber, Steven Finkbeiner

64) Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes (Nature Chemical Biology) Sunday October 30th 2011
Gregory C Patton, Pål Stenmark, Deviprasad R Gollapalli, Robin Sevastik, Petri Kursula, Susanne Flodin, Herwig Schuler, Colin T Swales, Hans Eklund, Fahmi Himo, Pär Nordlund, Lizbeth Hedstrom

65) A de novo peptide hexamer with a mutable channel (Nature Chemical Biology) Sunday October 30th 2011
Nathan R Zaccai, Bertie Chi, Andrew R Thomson, Aimee L Boyle, Gail J Bartlett, Marc Bruning, Noah Linden, Richard B Sessions, Paula J Booth, R Leo Brady, Derek N Woolfson

66) Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing (Nature Chemical Biology) Sunday October 23rd 2011
Ben G Small, Barry W McColl, Richard Allmendinger, Jürgen Pahle, Gloria López-Castejón, Nancy J Rothwell, Joshua Knowles, Pedro Mendes, David Brough, Douglas B Kell

67) GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis (Nature Chemical Biology) Sunday October 23rd 2011
Florence Verrier, Songon An, Ann M Ferrie, Haiyan Sun, Minjoung Kyoung, Huayun Deng, Ye Fang, Stephen J Benkovic

68) N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO (Nature Chemical Biology) Sunday October 16th 2011
Guifang Jia, Ye Fu, Xu Zhao, Qing Dai, Guanqun Zheng, Ying Yang, Chengqi Yi, Tomas Lindahl, Tao Pan, Yun-Gui Yang, Chuan He

69) α-ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition (Nature Chemical Biology) Sunday October 16th 2011
Christopher D Doucette, David J Schwab, Ned S Wingreen, Joshua D Rabinowitz

70) Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo (Nature Chemical Biology) Sunday October 16th 2011
Shehab A Ismail, Yong-Xiang Chen, Alexandra Rusinova, Anchal Chandra, Martin Bierbaum, Lothar Gremer, Gemma Triola, Herbert Waldmann, Philippe I H Bastiaens, Alfred Wittinghofer

71) A mass spectrometry–guided genome mining approach for natural product peptidogenomics (Nature Chemical Biology) Sunday October 9th 2011
Roland D Kersten, Yu-Liang Yang, Yuquan Xu, Peter Cimermancic, Sang-Jip Nam, William Fenical, Michael A Fischbach, Bradley S Moore, Pieter C Dorrestein

72) The proteoglycan bikunin has a defined sequence (Nature Chemical Biology) Sunday October 9th 2011
Mellisa Ly, Franklin E Leach, Tatiana N Laremore, Toshihiko Toida, I Jonathan Amster, Robert J Linhardt

73) Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation (Nature Chemical Biology) Sunday October 9th 2011
Je Won Park, Sung Ryeol Park, Keshav Kumar Nepal, Ah Reum Han, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eui Min Kim, Dooil Kim, Jae Kyung Sohng, Yeo Joon Yoon

74) Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4 (Nature Chemical Biology) Sunday October 2nd 2011
Michael Hothorn, Tsegaye Dabi, Joanne Chory

75) Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana (Nature Chemical Biology) Sunday September 25th 2011
Cyrille Y Botté, Michael Deligny, Aymeric Roccia, Anne-Laure Bonneau, Nadia Saïdani, Hélène Hardré, Samia Aci, Yoshiki Yamaryo-Botté, Juliette Jouhet, Emmanuelle Dubots, Karen Loizeau, Olivier Bastien, Laurent Bréhélin, Jacques Joyard, Jean-Christophe Cintrat, Denis Falconet, Maryse A Block, Bernard Rousseau, Roman Lopez, Eric Maréchal

76) (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 (Nature Chemical Biology) Sunday September 25th 2011
Kelsey C Duggan, Daniel J Hermanson, Joel Musee, Jeffery J Prusakiewicz, Jami L Scheib, Bruce D Carter, Surajit Banerjee, J A Oates, Lawrence J Marnett

77) Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 (Nature Chemical Biology) Sunday September 25th 2011
Kamalika Moulick, James H Ahn, Hongliang Zong, Anna Rodina, Leandro Cerchietti, Erica M Gomes DaGama, Eloisi Caldas-Lopes, Kristin Beebe, Fabiana Perna, Katerina Hatzi, Ly P Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Peter Smith-Jones, Mary Alpaugh, Steven S Gross, Nagavarakishore Pillarsetty, Thomas Ku, Jason S Lewis, Steven M Larson, Ross Levine, Hediye Erdjument-Bromage, Monica L Guzman, Stephen D Nimer, Ari Melnick, Len Neckers, Gabriela Chiosis

78) A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer (Nature Chemical Biology) Sunday September 25th 2011
Markus K Muellner, Iris Z Uras, Bianca V Gapp, Claudia Kerzendorfer, Michal Smida, Hannelore Lechtermann, Nils Craig-Mueller, Jacques Colinge, Gerhard Duernberger, Sebastian M B Nijman

79) On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds (Nature Chemical Biology) Sunday September 25th 2011
Tina R White, Chad M Renzelman, Arthur C Rand, Taha Rezai, Cayla M McEwen, Vladimir M Gelev, Rushia A Turner, Roger G Linington, Siegfried S F Leung, Amit S Kalgutkar, Jonathan N Bauman, Yizhong Zhang, Spiros Liras, David A Price, Alan M Mathiowetz, Matthew P Jacobson, R Scott Lokey

80) Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids (Nature Chemical Biology) Sunday September 18th 2011
Jonathan Z Long, Justin S Cisar, David Milliken, Sherry Niessen, Chu Wang, Sunia A Trauger, Gary Siuzdak, Benjamin F Cravatt

81) A natural prodrug activation mechanism in nonribosomal peptide synthesis (Nature Chemical Biology) Sunday September 18th 2011
Daniela Reimer, Klaas M Pos, Marco Thines, Peter Grün, Helge B Bode

82) Ligand discovery from a dopamine D3 receptor homology model and crystal structure (Nature Chemical Biology) Sunday September 18th 2011
Jens Carlsson, Ryan G Coleman, Vincent Setola, John J Irwin, Hao Fan, Avner Schlessinger, Andrej Sali, Bryan L Roth, Brian K Shoichet

83) RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites (Nature Chemical Biology) Sunday September 18th 2011
David B F Johnson, Jianfeng Xu, Zhouxin Shen, Jeffrey K Takimoto, Matthew D Schultz, Robert J Schmitz, Zheng Xiang, Joseph R Ecker, Steven P Briggs, Lei Wang

84) Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor (Nature Chemical Biology) Sunday September 11th 2011
Miguel A Mata, Neal Satterly, Gijs A Versteeg, Doug Frantz, Shuguang Wei, Noelle Williams, Mirco Schmolke, Samuel Peña-Llopis, James Brugarolas, Christian V Forst, Michael A White, Adolfo García-Sastre, Michael G Roth, Beatriz M A Fontoura

85) High-frequency transposition for determining antibacterial mode of action (Nature Chemical Biology) Sunday September 4th 2011
Hao Wang, David Claveau, John P Vaillancourt, Terry Roemer, Timothy C Meredith

86) A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance (Nature Chemical Biology) Sunday September 4th 2011
Meng Zhang, Shixian Lin, Xinwen Song, Jun Liu, Ye Fu, Xi Ge, Xinmiao Fu, Zengyi Chang, Peng R Chen

87) Epigenetics: Targeting leukemia on the DOT (Nature Chemical Biology) Sunday August 28th 2011
Jon Travers, Julian Blagg, Paul Workman

88) Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers (Nature Chemical Biology) Sunday August 28th 2011
Kou Qin, Chunmin Dong, Guangyu Wu, Nevin A Lambert

89) TRPA1 underlies a sensing mechanism for O2 (Nature Chemical Biology) Sunday August 28th 2011
Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Daisuke Kozai, Yusuke Mizuno, Shinichiro Yamamoto, Shinji Naito, Ellen Knevels, Peter Carmeliet, Toru Oga, Shuji Kaneko, Seiji Suga, Toshiki Nokami, Jun-ichi Yoshida, Yasuo Mori

90) Ligand binding to distinct states diverts aggregation of an amyloid-forming protein (Nature Chemical Biology) Sunday August 28th 2011
Lucy A Woods, Geoffrey W Platt, Andrew L Hellewell, Eric W Hewitt, Steve W Homans, Alison E Ashcroft, Sheena E Radford

91) Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions (Nature Chemical Biology) Sunday August 21st 2011
Richard W Gantt, Pauline Peltier-Pain, William J Cournoyer, Jon S Thorson

92) Multiple ligand-specific conformations of the β2-adrenergic receptor (Nature Chemical Biology) Sunday August 21st 2011
Alem W Kahsai, Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K Shukla, Jinpeng Sun, Terrence G Oas, Robert J Lefkowitz

93) Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism (Nature Chemical Biology) Sunday August 21st 2011
Anja Lehwess-Litzmann, Piotr Neumann, Christoph Parthier, Stefan Lüdtke, Ralph Golbik, Ralf Ficner, Kai Tittmann

94) The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine (Nature Chemical Biology) Sunday August 14th 2011
Hervé Roy, S Betty Zou, Tammy J Bullwinkle, Benjamin S Wolfe, Marla S Gilreath, Craig J Forsyth, William W Navarre, Michael Ibba

95) Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch (Nature Chemical Biology) Sunday August 14th 2011
Olga Pikovskaya, Anna Polonskaia, Dinshaw J Patel, Alexander Serganov

96) Natural products reveal cancer cell dependence on oxysterol-binding proteins (Nature Chemical Biology) Sunday August 7th 2011
Anthony W G Burgett, Thomas B Poulsen, Kittikhun Wangkanont, D Ryan Anderson, Chikako Kikuchi, Kousei Shimada, Shuichi Okubo, Kevin C Fortner, Yoshihiro Mimaki, Minpei Kuroda, Jason P Murphy, David J Schwalb, Eugene C Petrella, Ivan Cornella-Taracido, Markus Schirle, John A Tallarico, Matthew D Shair

97) Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase (Nature Chemical Biology) Sunday August 7th 2011
Seung Seo Lee, Sung You Hong, James C Errey, Atsushi Izumi, Gideon J Davies, Benjamin G Davis

98) Mussel protein adhesion depends on interprotein thiol-mediated redox modulation (Nature Chemical Biology) Sunday July 31st 2011
Jing Yu, Wei Wei, Eric Danner, Rebekah K Ashley, Jacob N Israelachvili, J Herbert Waite

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- TCNE: Molecular Magnet, Unicorn Killer
Carbon-Based Curiosities
- Chemistry World’s roundup of money and molecules
Chemistry World blog
- Solid Phase Extraction
ChemScrapes
- Photolysis
ChemScrapes
- Washington Post reporter wants to talk to recently unemployed scientists
Chemjobber
- Independence: learn to be a Big Player in the lab
Chemjobber
- Awesome Reader of the Century of the week: "Chemist"
Chemjobber
- The Genetic Diversity of Cancer Cells
In the Pipeline
- Strangely Good Results in Diabetes and Cardiovascular Disease
In the Pipeline
- De-caffeinating pills? Say it ain't so, Think Geek
C&ENtral Science
- Space, electric cars and philanthropy
Babbage
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Mitch Andre Garcia's Chem Feeds 2008-present

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