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1) Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (Nature Biotechnology) Monday May 2nd 2016
Benjamin L Oakes, Dana C Nadler, Avi Flamholz, Christof Fellmann, Brett T Staahl, Jennifer A Doudna, David F Savage

2) CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes (Nature Biotechnology) Monday April 25th 2016
Bastiaan Evers, Katarzyna Jastrzebski, Jeroen P M Heijmans, Wipawadee Grernrum, Roderick L Beijersbergen, Rene Bernards

3) A pigeonpea gene confers resistance to Asian soybean rust in soybean (Nature Biotechnology) Monday April 25th 2016
Cintia G Kawashima, Gustavo Augusto Guimar, S, Dan MacLean, Doug R Cook, Burkhard Steuernagel, Jongmin Baek, Costas Bouyioukos, Bernardo do V A Melo, Gustavo Trist, Jamile Camargos de Oliveira, Gilda Rauscher, Shipra Mittal, Lisa Panichelli, Karen Bacot, Ebony Johnson, Geeta Iyer, Girma Tabor, Brande B H Wulff, Eric Ward, Gregory J Rairdan, Karen E Broglie, Gusui Wu, H Peter van Esse, Jonathan D G Jones, S

4) Rapid cloning of disease-resistance genes in plants using mutagenesis and sequence capture (Nature Biotechnology) Monday April 25th 2016
Burkhard Steuernagel, Sambasivam K Periyannan, Inmaculada Hern, Kamil Witek, Matthew N Rouse, Guotai Yu, Asyraf Hatta, Mick Ayliffe, Harbans Bariana, Jonathan D G Jones, Evans S Lagudah, Brande B H Wulff

5) Accelerated cloning of a potato late blight (Nature Biotechnology) Monday April 25th 2016
Kamil Witek, Florian Jupe, Agnieszka I Witek, David Baker, Matthew D Clark, Jonathan D G Jones

6) Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow (Nature Biotechnology) Tuesday April 19th 2016
Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximiliaan Huisman, Shaojie Zhang, David Grunwald, Thoru Pederson

7) Characterizing genomic alterations in cancer by complementary functional associations (Nature Biotechnology) Tuesday April 19th 2016
Jong Wook Kim, Olga B Botvinnik, Omar Abudayyeh, Chet Birger, Joseph Rosenbluh, Yashaswi Shrestha, Mohamed E Abazeed, Peter S Hammerman, Daniel DiCara, David J Konieczkowski, Cory M Johannessen, Arthur Liberzon, Amir Reza Alizad-Rahvar, Gabriela Alexe, Andrew Aguirre, Mahmoud Ghandi, Heidi Greulich, Francisca Vazquez, Barbara A Weir, Eliezer M Van Allen, Aviad Tsherniak, Diane D Shao, Travis I Zack, Michael Noble, Gad Getz, Rameen Beroukhim, Levi A Garraway, Masoud Ardakani, Chiara Romualdi, Gabriele Sales, David A Barbie, Jesse S Boehm, William C Hahn, Jill P Mesirov, Pablo Tamayo

8) Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions (Nature Biotechnology) Tuesday April 19th 2016
Seokjung Cheong, James M Clomburg, Ramon Gonzalez

9) Sequencing wild and cultivated cassava and related species reveals extensive interspecific hybridization and genetic diversity (Nature Biotechnology) Monday April 18th 2016
Jessen V Bredeson, Jessica B Lyons, Simon E Prochnik, G Albert Wu, Cindy M Ha, Eric Edsinger-Gonzales, Jane Grimwood, Jeremy Schmutz, Ismail Y Rabbi, Chiedozie Egesi, Poasa Nauluvula, Vincent Lebot, Joseph Ndunguru, Geoffrey Mkamilo, Rebecca S Bart, Tim L Setter, Roslyn M Gleadow, Peter Kulakow, Morag E Ferguson, Steve Rounsley, Daniel S Rokhsar

10) Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases (Nature Biotechnology) Tuesday April 12th 2016
Rong Chen, Lisong Shi, J, Brian Naughton, Pamela Sklar, Jianguo Zhang, Hanlin Zhou, Lifeng Tian, Om Prakash, Mathieu Lemire, Patrick Sleiman, Wei-yi Cheng, Wanting Chen, Hardik Shah, Yulan Shen, Menachem Fromer, Larsson Omberg, Matthew A Deardorff, Elaine Zackai, Jason R Bobe, Elissa Levin, Thomas J Hudson, Leif Groop, Jun Wang, Hakon Hakonarson, Anne Wojcicki, George A Diaz, Lisa Edelmann, Eric E Schadt, Stephen H Friend

11) Superheroes of disease resistance (Nature Biotechnology) Monday April 11th 2016
Daniel MacArthur

12) Near-optimal probabilistic RNA-seq quantification (Nature Biotechnology) Monday April 4th 2016
Nicolas L Bray, Harold Pimentel, P, Lior Pachter

13) Integrated digital error suppression for improved detection of circulating tumor DNA (Nature Biotechnology) Saturday April 2nd 2016
Aaron M Newman, Alexander F Lovejoy, Daniel M Klass, David M Kurtz, Jacob J Chabon, Florian Scherer, Henning Stehr, Chih Long Liu, Scott V Bratman, Carmen Say, Li Zhou, Justin N Carter, Robert B West, George W Sledge Jr, Joseph B Shrager, Billy W Loo, Joel W Neal, Heather A Wakelee, Maximilian Diehn, Ash A Alizadeh

14) An injectable nanoparticle generator enhances delivery of cancer therapeutics (Nature Biotechnology) Monday March 14th 2016
Rong Xu, Guodong Zhang, Junhua Mai, Xiaoyong Deng, Victor Segura-Ibarra, Suhong Wu, Jianliang Shen, Haoran Liu, Zhenhua Hu, Lingxiao Chen, Yi Huang, Eugene Koay, Yu Huang, Jun Liu, Joe E Ensor, Elvin Blanco, Xuewu Liu, Mauro Ferrari, Haifa Shen

15) One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli (Nature Biotechnology) Monday March 14th 2016
So Young Choi, Si Jae Park, Won Jun Kim, Jung Eun Yang, Hyuk Lee, Jihoon Shin, Sang Yup Lee

16) Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease (Nature Biotechnology) Monday March 14th 2016
Suk See De Ravin, Andreas Reik, Pei-Qi Liu, Linhong Li, Xiaolin Wu, Ling Su, Castle Raley, Narda Theobald, Uimook Choi, Alexander H Song, Andy Chan, Jocelynn R Pearl, David E Paschon, Janet Lee, Hannah Newcombe, Sherry Koontz, Colin Sweeney, David A Shivak, Kol A Zarember, Madhusudan V Peshwa, Philip D Gregory, Fyodor D Urnov, Harry L Malech

17) First, design for data sharing (Nature Biotechnology) Thursday March 3rd 2016
John Wilbanks, Stephen H Friend

18) High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines (Nature Biotechnology) Monday February 29th 2016
Channing Yu, Aristotle M Mannan, Griselda Metta Yvone, Kenneth N Ross, Yan-Ling Zhang, Melissa A Marton, Bradley R Taylor, Andrew Crenshaw, Joshua Z Gould, Pablo Tamayo, Barbara A Weir, Aviad Tsherniak, Bang Wong, Levi A Garraway, Alykhan F Shamji, Michelle A Palmer, Michael A Foley, Wendy Winckler, Stuart L Schreiber, Andrew L Kung, Todd R Golub

19) Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity (Nature Biotechnology) Monday February 22nd 2016
Janet Karpinski, Ilona Hauber, Jan Chemnitz, Carola Sch, Maciej Paszkowski-Rogacz, Deboyoti Chakraborty, Niklas Beschorner, Helga Hofmann-Sieber, Ulrike C Lange, Adam Grundhoff, Karl Hackmann, Evelin Schrock, Josephine Abi-Ghanem, M Teresa Pisabarro, Vineeth Surendranath, Axel Schambach, Christoph Lindner, Jan van Lunzen, Joachim Hauber, Frank Buchholz

20) Transcriptome-scale RNase-footprinting of RNA-protein complexes (Nature Biotechnology) Monday February 22nd 2016
Zhe Ji, Ruisheng Song, Hailiang Huang, Aviv Regev, Kevin Struhl

21) Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy (Nature Biotechnology) Monday February 22nd 2016
Lingfeng Liu, Daniel Sommermeyer, Alexandra Cabanov, Paula Kosasih, Tyler Hill, Stanley R Riddell

22) A 3D bioprinting system to produce human-scale tissue constructs with structural integrity (Nature Biotechnology) Monday February 15th 2016
Hyun-Wook Kang, Sang Jin Lee, In Kap Ko, Carlos Kengla, James J Yoo, Anthony Atala

23) Fast search of thousands of short-read sequencing experiments (Nature Biotechnology) Monday February 8th 2016
Brad Solomon, Carl Kingsford

24) Haplotyping germline and cancer genomes with high-throughput linked-read sequencing (Nature Biotechnology) Monday February 1st 2016
Grace X Y Zheng, Billy T Lau, Michael Schnall-Levin, Mirna Jarosz, John M Bell, Christopher M Hindson, Sofia Kyriazopoulou-Panagiotopoulou, Donald A Masquelier, Landon Merrill, Jessica M Terry, Patrice A Mudivarti, Paul W Wyatt, Rajiv Bharadwaj, Anthony J Makarewicz, Yuan Li, Phillip Belgrader, Andrew D Price, Adam J Lowe, Patrick Marks, Gerard M Vurens, Paul Hardenbol, Luz Montesclaros, Melissa Luo, Lawrence Greenfield, Alexander Wong, David E Birch, Steven W Short, Keith P Bjornson, Pranav Patel, Erik S Hopmans, Christina Wood, Sukhvinder Kaur, Glenn K Lockwood, David Stafford, Joshua P Delaney, Indira Wu, Heather S Ordonez, Susan M Grimes, Stephanie Greer, Josephine Y Lee, Kamila Belhocine, Kristina M Giorda, William H Heaton, Geoffrey P McDermott, Zachary W Bent, Francesca Meschi, Nikola O Kondov, Ryan Wilson, Jorge A Bernate, Shawn Gauby, Alex Kindwall, Clara Bermejo, Adrian N Fehr, Adrian Chan, Serge Saxonov, Kevin D Ness, Benjamin J Hindson, Hanlee P Ji

25) Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain (Nature Biotechnology) Monday February 1st 2016
Benjamin E Deverman, Piers L Pravdo, Bryan P Simpson, Sripriya Ravindra Kumar, Ken Y Chan, Abhik Banerjee, Wei-Li Wu, Bin Yang, Nina Huber, Sergiu P Pasca, Viviana Gradinaru

26) A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice (Nature Biotechnology) Monday February 1st 2016
Yang Yang, Lili Wang, Peter Bell, Deirdre McMenamin, Zhenning He, John White, Hongwei Yu, Chenyu Xu, Hiroki Morizono, Kiran Musunuru, Mark L Batshaw, James M Wilson

27) Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo (Nature Biotechnology) Monday February 1st 2016
Hao Yin, Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet F Bolukbasi, Stephen Walsh, Roman L Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A Wolfe, Robert Langer, Wen Xue, Daniel G Anderson

28) High-throughput mapping of regulatory DNA (Nature Biotechnology) Monday January 25th 2016
Nisha Rajagopal, Sharanya Srinivasan, Kameron Kooshesh, Yuchun Guo, Matthew D Edwards, Budhaditya Banerjee, Tahin Syed, Bart J M Emons, David K Gifford, Richard I Sherwood

29) Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates (Nature Biotechnology) Monday January 25th 2016
Arturo J Vegas, Omid Veiseh, Joshua C Doloff, Minglin Ma, Hok Hei Tam, Kaitlin Bratlie, Jie Li, Andrew R Bader, Erin Langan, Karsten Olejnik, Patrick Fenton, Jeon Woong Kang, Jennifer Hollister-Locke, Matthew A Bochenek, Alan Chiu, Sean Siebert, Katherine Tang, Siddharth Jhunjhunwala, Stephanie Aresta-Dasilva, Nimit Dholakia, Raj Thakrar, Thema Vietti, Michael Chen, Josh Cohen, Karolina Siniakowicz, Meirigeng Qi, James McGarrigle, Stephen Lyle, David M Harlan, Dale L Greiner, Jose Oberholzer, Gordon C Weir, Robert Langer, Daniel G Anderson

30) Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA (Nature Biotechnology) Wednesday January 20th 2016
Christopher D Richardson, Graham J Ray, Mark A DeWitt, Gemma L Curie, Jacob E Corn

31) Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 (Nature Biotechnology) Monday January 18th 2016
John G Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W Vaimberg, Katherine F Donovan, Ian Smith, Zuzana Tothova, Craig Wilen, Robert Orchard, Herbert W Virgin, Jennifer Listgarten, David E Root

32) Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9 (Nature Biotechnology) Monday January 18th 2016
Gozde Korkmaz, Rui Lopes, Alejandro P Ugalde, Ekaterina Nevedomskaya, Ruiqi Han, Ksenia Myacheva, Wilbert Zwart, Ran Elkon, Reuven Agami

33) Antisense oligonucleotide (Nature Biotechnology) Monday December 21st 2015
Tomoki T Nomakuchi, Frank Rigo, Isabel Aznarez, Adrian R Krainer

34) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes (Nature Biotechnology) Monday December 21st 2015
J, Amit Zeisel, Zolt, Daniela Calvigioni, Yuchio Yanagawa, G, Sten Linnarsson, Tibor Harkany

35) Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines (Nature Biotechnology) Monday December 21st 2015
Jungseog Kang, Chien-Hsiang Hsu, Qi Wu, Shanshan Liu, Adam D Coster, Bruce A Posner, Steven J Altschuler, Lani F Wu

36) Synthetic long-read sequencing reveals intraspecies diversity in the human microbiome (Nature Biotechnology) Monday December 21st 2015
Volodymyr Kuleshov, Chao Jiang, Wenyu Zhou, Fereshteh Jahanbani, Serafim Batzoglou, Michael Snyder

37) Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq (Nature Biotechnology) Monday December 21st 2015
Cathryn R Cadwell, Athanasia Palasantza, Xiaolong Jiang, Philipp Berens, Qiaolin Deng, Marlene Yilmaz, Jacob Reimer, Shan Shen, Matthias Bethge, Kimberley F Tolias, Rickard Sandberg, Andreas S Tolias

38) Generation of serotonin neurons from human pluripotent stem cells (Nature Biotechnology) Monday December 21st 2015
Jianfeng Lu, Xuefei Zhong, Huisheng Liu, Ling Hao, Cindy Tzu-Ling Huang, Mohammad Amin Sherafat, Jeffrey Jones, Melvin Ayala, Lingjun Li, Su-Chun Zhang

39) A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae (Nature Biotechnology) Monday December 7th 2015
Andrew Hammond, Roberto Galizi, Kyros Kyrou, Alekos Simoni, Carla Siniscalchi, Dimitris Katsanos, Matthew Gribble, Dean Baker, Eric Marois, Steven Russell, Austin Burt, Nikolai Windbichler, Andrea Crisanti, Tony Nolan

40) The quantitative and condition-dependent Escherichia coli proteome (Nature Biotechnology) Monday December 7th 2015
Alexander Schmidt, Karl Kochanowski, Silke Vedelaar, Erik Ahrn, Benjamin Volkmer, Luciano Callipo, K, Manuel Bauer, Ruedi Aebersold, Matthias Heinemann

41) Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus (Nature Biotechnology) Monday December 7th 2015
Kristin M Whitworth, Raymond R R Rowland, Catherine L Ewen, Benjamin R Trible, Maureen A Kerrigan, Ada G Cino-Ozuna, Melissa S Samuel, Jonathan E Lightner, David G McLaren, Alan J Mileham, Kevin D Wells, Randall S Prather

42) Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity (Nature Biotechnology) Monday November 30th 2015
Matthew T Chang, Saurabh Asthana, Sizhi Paul Gao, Byron H Lee, Jocelyn S Chapman, Cyriac Kandoth, JianJiong Gao, Nicholas D Socci, David B Solit, Adam B Olshen, Nikolaus Schultz, Barry S Taylor

43) Mapping the effects of drugs on the immune system (Nature Biotechnology) Monday November 30th 2015
Brian A Kidd, Aleksandra Wroblewska, Mary R Boland, Judith Agudo, Miriam Merad, Nicholas P Tatonetti, Brian D Brown, Joel T Dudley

44) Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids (Nature Biotechnology) Tuesday November 17th 2015
Miriam Amiram, Adrian D Haimovich, Chenguang Fan, Yane-Shih Wang, Hans-Rudolf Aerni, Ioanna Ntai, Daniel W Moonan, Natalie J Ma, Alexis J Rovner, Seok Hoon Hong, Neil L Kelleher, Andrew L Goodman, Michael C Jewett, Dieter S, Jesse Rinehart, Farren J Isaacs

45) Safeguarding CRISPR-Cas9 gene drives in yeast (Nature Biotechnology) Tuesday November 17th 2015
James E DiCarlo, Alejandro Chavez, Sven L Dietz, Kevin M Esvelt, George M Church

46) Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors (Nature Biotechnology) Tuesday November 17th 2015
Jianbin Wang, Colin M Exline, Joshua J DeClercq, G Nicholas Llewellyn, Samuel B Hayward, Patrick Wai-Lun Li, David A Shivak, Richard T Surosky, Philip D Gregory, Michael C Holmes, Paula M Cannon

47) Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides (Nature Biotechnology) Tuesday November 17th 2015
Shisheng Sun, Punit Shah, Shadi Toghi Eshghi, Weiming Yang, Namita Trikannad, Shuang Yang, Lijun Chen, Paul Aiyetan, Naseruddin H, Zhen Zhang, Daniel W Chan, Hui Zhang

48) Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics (Nature Biotechnology) Tuesday November 17th 2015
Sung Il Park, Daniel S Brenner, Gunchul Shin, Clinton D Morgan, Bryan A Copits, Ha Uk Chung, Melanie Y Pullen, Kyung Nim Noh, Steve Davidson, Soong Ju Oh, Jangyeol Yoon, Kyung-In Jang, Vijay K Samineni, Megan Norman, Jose G Grajales-Reyes, Sherri K Vogt, Saranya S Sundaram, Kellie M Wilson, Jeong Sook Ha, Renxiao Xu, Taisong Pan, Tae-il Kim, Yonggang Huang, Michael C Montana, Judith P Golden, Michael R Bruchas, Robert W Gereau, John A Rogers

49) Affinity regression predicts the recognition code of nucleic acid (Nature Biotechnology) Tuesday November 17th 2015
Raphael Pelossof, Irtisha Singh, Julie L Yang, Matthew T Weirauch, Timothy R Hughes, Christina S Leslie

50) GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions (Nature Biotechnology) Monday November 2nd 2015
Judith Agudo, Albert Ruzo, Eun Sook Park, Robert Sweeney, Veronika Kana, Meng Wu, Yong Zhao, Dieter Egli, Miriam Merad, Brian D Brown

51) Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition (Nature Biotechnology) Monday November 2nd 2015
Benjamin P Kleinstiver, Michelle S Prew, Shengdar Q Tsai, Nhu T Nguyen, Ved V Topkar, Zongli Zheng, J Keith Joung

52) A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs (Nature Biotechnology) Monday October 26th 2015
Jiho Choi, Soohyun Lee, William Mallard, Kendell Clement, Guidantonio Malagoli Tagliazucchi, Hotae Lim, In Young Choi, Francesco Ferrari, Alexander M Tsankov, Ramona Pop, Gabsang Lee, John L Rinn, Alexander Meissner, Peter J Park, Konrad Hochedlinger

53) Long-term culture and expansion of primary human hepatocytes (Nature Biotechnology) Monday October 26th 2015
Gahl Levy, David Bomze, Stefan Heinz, Sarada Devi Ramachandran, Astrid Noerenberg, Merav Cohen, Oren Shibolet, Ella Sklan, Joris Braspenning, Yaakov Nahmias

54) In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity (Nature Biotechnology) Monday October 26th 2015
Geoffrey M Lynn, Richard Laga, Patricia A Darrah, Andrew S Ishizuka, Alexandra J Balaci, Andr, Michal Pechar, Robert Pola, Michael Y Gerner, Ayako Yamamoto, Connor R Buechler, Kylie M Quinn, Margery G Smelkinson, Ondrej Vanek, Ryan Cawood, Thomas Hills, Olga Vasalatiy, Kathrin Kastenm, Joseph R Francica, Lalisa Stutts, Janine K Tom, Keun Ah Ryu, Aaron P Esser-Kahn, Tomas Etrych, Kerry D Fisher, Leonard W Seymour, Robert A Seder

55) A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells (Nature Biotechnology) Monday October 26th 2015
Alexander M Tsankov, Veronika Akopian, Ramona Pop, Sundari Chetty, Casey A Gifford, Laurence Daheron, Nadejda M Tsankova, Alexander Meissner

56) Comprehensive characterization of the Published Kinase Inhibitor Set (Nature Biotechnology) Monday October 26th 2015
Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai Sepetov, Xi-Ping Huang, Bryan L Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A Teicher, Mark Kunkel, Eric Polley, Karen E Lackey, Francis L Atkinson, John P Overington, Paul Bamborough, Susanne M, Daniel J Price, Timothy M Willson, David H Drewry, Stefan Knapp, William J Zuercher

57) DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins (Nature Biotechnology) Monday October 19th 2015
Je Wook Woo, Jungeun Kim, Soon Il Kwon, Claudia Corval, Seung Woo Cho, Hyeran Kim, Sang-Gyu Kim, Sang-Tae Kim, Sunghwa Choe, Jin-Soo Kim

58) Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state (Nature Biotechnology) Monday October 12th 2015
Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Alon Goren, David A Weitz, Bradley E Bernstein

59) Nephron organoids derived from human pluripotent stem cells model kidney development and injury (Nature Biotechnology) Monday October 12th 2015
Ryuji Morizane, Albert Q Lam, Benjamin S Freedman, Seiji Kishi, M Todd Valerius, Joseph V Bonventre

60) Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease (Nature Biotechnology) Monday October 5th 2015
James E Dahlman, Omar O Abudayyeh, Julia Joung, Jonathan S Gootenberg, Feng Zhang, Silvana Konermann

61) Subangstrom single-molecule measurements of motor proteins using a nanopore (Nature Biotechnology) Tuesday September 29th 2015
Ian M Derrington, Jonathan M Craig, Eric Stava, Andrew H Laszlo, Brian C Ross, Henry Brinkerhoff, Ian C Nova, Kenji Doering, Benjamin I Tickman, Mostafa Ronaghi, Jeffrey G Mandell, Kevin L Gunderson, Jens H Gundlach

62) A catalog of the mouse gut metagenome (Nature Biotechnology) Tuesday September 29th 2015
Liang Xiao, Qiang Feng, Suisha Liang, Si Brask Sonne, Zhongkui Xia, Xinmin Qiu, Xiaoping Li, Hua Long, Jianfeng Zhang, Dongya Zhang, Chuan Liu, Zhiwei Fang, Joyce Chou, Jacob Glanville, Qin Hao, Dorota Kotowska, Camilla Colding, Tine Rask Licht, Donghai Wu, Jun Yu, Joseph Jao Yiu Sung, Qiaoyi Liang, Junhua Li, Huijue Jia, Zhou Lan, Valentina Tremaroli, Piotr Dworzynski, H Bj, Fredrik B, Jo, Emmanuelle Le Chatelier, S Dusko Ehrlich, John C Lin, Manimozhiyan Arumugam, Jun Wang, Lise Madsen, Karsten Kristiansen

63) Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering (Nature Biotechnology) Monday September 21st 2015
Dieter Blancquaert, Jeroen Van Daele, Simon Strobbe, Filip Kiekens, Sergei Storozhenko, Hans De Steur, Xavier Gellynck, Willy Lambert, Christophe Stove, Dominique Van Der Straeten

64) Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes (Nature Biotechnology) Tuesday September 15th 2015
Sachet A Shukla, Michael S Rooney, Mohini Rajasagi, Grace Tiao, Philip M Dixon, Michael S Lawrence, Jonathan Stevens, William J Lane, Jamie L Dellagatta, Scott Steelman, Carrie Sougnez, Kristian Cibulskis, Adam Kiezun, Nir Hacohen, Vladimir Brusic, Catherine J Wu, Gad Getz

65) Optogenetic control of endogenous Ca2+ channels in vivo (Nature Biotechnology) Monday September 14th 2015
Taeyoon Kyung, Sangkyu Lee, Jung Eun Kim, Taesup Cho, Hyerim Park, Yun-Mi Jeong, Dongkyu Kim, Anna Shin, Sungsoo Kim, Jinhee Baek, Jihoon Kim, Na Yeon Kim, Doyeon Woo, Sujin Chae, Cheol-Hee Kim, Hee-Sup Shin, Yong-Mahn Han, Daesoo Kim, Won Do Heo

66) Engineering pulmonary vasculature in decellularized rat and human lungs (Nature Biotechnology) Monday September 14th 2015
Xi Ren, Philipp T Moser, Sarah E Gilpin, Tatsuya Okamoto, Tong Wu, Luis F Tapias, Francois E Mercier, Linjie Xiong, Raja Ghawi, David T Scadden, Douglas J Mathisen, Harald C Ott

67) Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning (Nature Biotechnology) Monday September 14th 2015
Brian Cleary, Ilana Lauren Brito, Katherine Huang, Dirk Gevers, Terrance Shea, Sarah Young, Eric J Alm

68) De novo sequencing and variant calling with nanopores using PoreSeq (Nature Biotechnology) Thursday September 10th 2015
Tamas Szalay, Jene A Golovchenko

69) ConStrains identifies microbial strains in metagenomic datasets (Nature Biotechnology) Monday September 7th 2015
Chengwei Luo, Rob Knight, Heli Siljander, Mikael Knip, Ramnik J Xavier, Dirk Gevers

70) Massively parallel high-order combinatorial genetics in human cells (Nature Biotechnology) Monday August 17th 2015
Alan S L Wong, Gigi C G Choi, Allen A Cheng, Oliver Purcell, Timothy K Lu

71) High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics (Nature Biotechnology) Monday August 17th 2015
Sean J Humphrey, S Babak Azimifar, Matthias Mann

72) Overexpression of receptor-like kinase ERECTA improves thermotolerance in rice and tomato (Nature Biotechnology) Monday August 17th 2015
Hui Shen, Xiangbin Zhong, Fangfang Zhao, Yanmei Wang, Bingxiao Yan, Qun Li, Genyun Chen, Bizeng Mao, Jianjun Wang, Yangsheng Li, Guoying Xiao, Yuke He, Han Xiao, Jianming Li, Zuhua He

73) Prediction of human population responses to toxic compounds by a collaborative competition (Nature Biotechnology) Monday August 10th 2015
Federica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher Bare, Ruili Huang, Thea Norman, Mike Kellen, Michael P Menden, Jichen Yang, Xiaowei Zhan, Rui Zhong, Guanghua Xiao, Menghang Xia, Nour Abdo, Oksana Kosyk, Federica Eduati, Lara M Mangravite, J Christopher Bare, Thea Norman, Mike Kellen, Michael P Menden, Stephen Friend, Gustavo Stolovitzky, Allen Dearry, Raymond R Tice, Ruili Huang, Menghang Xia, Anton Simeonov, Nour Abdo, Oksana Kosyk, Ivan Rusyn, Fred A Wright, Tao Wang, Hao Tang, Xiaowei Zhan, Jichen Yang, Rui Zhong, Guanghua Xiao, Yang Xie, Hao Tang, Jichen Yang, Tao Wang, Guanghua Xiao, Yang Xie, Salvatore Alaimo, Alicia Amadoz, Muhammad Ammad-ud-din, Chlo, Jaume Bacardit, Pelham Barron, Elsa Bernard, Andreas Beyer, Shao Bin, Alena van B, Karsten Borgwardt, April M Brys, Brian Caffrey, Jeffrey Chang, Jungsoo Chang, Eleni G Christodoulou, Mathieu Cl, Trevor Cohen, Marianne Cowherd, Sofie Demeyer, Joaquin Dopazo, Joel D Elhard, Andre O Falcao, Alfredo Ferro, David A Friedenberg, Rosalba Giugno, Yunguo Gong, Jenni W Gorospe, Courtney A Granville, Dominik Grimm, Matthias Heinig, Rosa D Hernansaiz, Sepp Hochreiter, Liang-Chin Huang, Matthew Huska, Yunlong Jiao, G, Michael Kuhn, Miron Bartosz Kursa, Rintu Kutum, Nicola Lazzarini, Inhan Lee, Michael K K Leung, Weng Khong Lim, Charlie Liu, Felipe Llinares L, Alessandro Mammana, Andreas Mayr, Tom Michoel, Misael Mongiov, Jonathan D Moore, Ravi Narasimhan, Stephen O Opiyo, Gaurav Pandey, Andrea L Peabody, Juliane Perner, Alfredo Pulvirenti, Konrad Rawlik, Susanne Reinhardt, Carol G Riffle, Douglas Ruderfer, Aaron J Sander, Richard S Savage, Erwan Scornet, Patricia Sebastian-Leon, Roded Sharan, Carl Johann Simon-Gabriel, Veronique Stoven, Jingchun Sun, Hao Tang, Ana L Teixeira, Albert Tenesa, Jean-Philippe Vert, Martin Vingron, Tao Wang, Thomas Walter, Sean Whalen, Zofia Wi, Yonghui Wu, Guanghua Xiao, Yang Xie, Hua Xu, Jichen Yang, Xiaowei Zhan, Shihua Zhang, Junfei Zhao, W Jim Zheng, Rui Zhong, Dai Ziwei, Stephen Friend, Allen Dearry, Anton Simeonov, Raymond R Tice, Ivan Rusyn, Fred A Wright, Gustavo Stolovitzky, Yang Xie, Julio Saez-Rodriguez

74) Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery (Nature Biotechnology) Monday August 3rd 2015
Liliana Wroblewska, Tasuku Kitada, Kei Endo, Velia Siciliano, Breanna Stillo, Hirohide Saito, Ron Weiss

75) Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy (Nature Biotechnology) Monday August 3rd 2015
J, Masayuki Oginuma, Ziad Al Tanoury, B, Olga Sumara, Aurore Hick, Fanny Bousson, Yasmine Zidouni, Caroline Mursch, Philippe Moncuquet, Olivier Tassy, St, Ayako Miyanari, Agata Bera, Jean-Marie Garnier, Getzabel Guevara, Marie Hestin, Leif Kennedy, Shinichiro Hayashi, Bernadette Drayton, Thomas Cherrier, Barbara Gayraud-Morel, Emanuela Gussoni, Fr, Shahragim Tajbakhsh, Olivier Pourqui

76) High-throughput determination of RNA structure by proximity ligation (Nature Biotechnology) Monday August 3rd 2015
Vijay Ramani, Ruolan Qiu, Jay Shendure

77) Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning (Nature Biotechnology) Monday July 27th 2015
Babak Alipanahi, Andrew Delong, Matthew T Weirauch, Brendan J Frey

78) Engineered CHO cells for production of diverse, homogeneous glycoproteins (Nature Biotechnology) Monday July 20th 2015
Zhang Yang, Shengjun Wang, Adnan Halim, Morten Alder Schulz, Morten Frodin, Shamim H Rahman, Malene B Vester-Christensen, Carsten Behrens, Claus Kristensen, Sergey Y Vakhrushev, Eric Paul Bennett, Hans H Wandall, Henrik Clausen

79) Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells (Nature Biotechnology) Monday July 20th 2015
Matthew J Birket, Marcelo C Ribeiro, Arie O Verkerk, Dorien Ward, Ana Rita Leitoguinho, Sabine C den Hartogh, Valeria V Orlova, Harsha D Devalla, Verena Schwach, Milena Bellin, Robert Passier, Christine L Mummery

80) High-throughput sequencing of DNA G-quadruplex structures in the human genome (Nature Biotechnology) Monday July 20th 2015
Vicki S Chambers, Giovanni Marsico, Jonathan M Boutell, Marco Di Antonio, Geoffrey P Smith, Shankar Balasubramanian

81) Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown (Nature Biotechnology) Monday July 20th 2015
Anders Wittrup, Angela Ai, Xing Liu, Peter Hamar, Radiana Trifonova, Klaus Charisse, Muthiah Manoharan, Tomas Kirchhausen, Judy Lieberman

82) Directed differentiation of cholangiocytes from human pluripotent stem cells (Nature Biotechnology) Wednesday July 15th 2015
Mina Ogawa, Shinichiro Ogawa, Christine E Bear, Saumel Ahmadi, Stephanie Chin, Bin Li, Markus Grompe, Gordon Keller, Binita M Kamath, Anand Ghanekar

83) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation (Nature Biotechnology) Wednesday July 15th 2015
Fotios Sampaziotis, Miguel Cardoso de Brito, Pedro Madrigal, Alessandro Bertero, Kourosh Saeb-Parsy, Filipa A C Soares, Elisabeth Schrumpf, Espen Melum, Tom H Karlsen, J Andrew Bradley, William T H Gelson, Susan Davies, Alastair Baker, Arthur Kaser, Graeme J Alexander, Nicholas R F Hannan, Ludovic Vallier

84) Expression of trehalose-6-phosphate phosphatase in maize ears improves yield in well-watered and drought conditions (Nature Biotechnology) Monday July 6th 2015
Michael L Nuccio, Jeff Wu, Ron Mowers, Hua-Ping Zhou, Moez Meghji, Lucia F Primavesi, Matthew J Paul, Xi Chen, Yan Gao, Emdadul Haque, Shib Sankar Basu, L Mark Lagrimini

85) Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation (Nature Biotechnology) Monday June 29th 2015
Dimos Gaidatzis, Lukas Burger, Maria Florescu, Michael B Stadler

86) Kinetic fingerprinting to identify and count single nucleic acids (Nature Biotechnology) Monday June 29th 2015
Alexander Johnson-Buck, Xin Su, Maria D Giraldez, Meiping Zhao, Muneesh Tewari, Nils G Walter

87) Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells (Nature Biotechnology) Monday June 29th 2015
Ayal Hendel, Rasmus O Bak, Joseph T Clark, Andrew B Kennedy, Daniel E Ryan, Subhadeep Roy, Israel Steinfeld, Benjamin D Lunstad, Robert J Kaiser, Alec B Wilkens, Rosa Bacchetta, Anya Tsalenko, Douglas Dellinger, Laurakay Bruhn, Matthew H Porteus

88) Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage (Nature Biotechnology) Monday June 29th 2015
Ori Bar-Nur, Cassandra Verheul, Andreia G Sommer, Justin Brumbaugh, Benjamin A Schwarz, Inna Lipchina, Aaron J Huebner, Gustavo Mostoslavsky, Konrad Hochedlinger

89) Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors (Nature Biotechnology) Monday June 29th 2015
Itay Maza, Inbal Caspi, Asaf Zviran, Elad Chomsky, Yoach Rais, Sergey Viukov, Shay Geula, Jason D Buenrostro, Leehee Weinberger, Vladislav Krupalnik, Suhair Hanna, Mirie Zerbib, James R Dutton, William J Greenleaf, Rada Massarwa, Noa Novershtern, Jacob H Hanna

90) Optogenetics for in vivo cardiac pacing and resynchronization therapies (Nature Biotechnology) Monday June 29th 2015
Udi Nussinovitch, Lior Gepstein

91) Flexible guide-RNA design for CRISPR applications using Protospacer Workbench (Nature Biotechnology) Monday June 29th 2015
Cameron Ross MacPherson, Artur Scherf

92) Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index (Nature Biotechnology) Monday June 15th 2015
Robert P Lyon, Tim D Bovee, Svetlana O Doronina, Patrick J Burke, Joshua H Hunter, Haley D Neff-LaFord, Mechthild Jonas, Martha E Anderson, Jocelyn R Setter, Peter D Senter

93) A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides (Nature Biotechnology) Monday June 15th 2015
Joel M Chick, Deepak Kolippakkam, David P Nusinow, Bo Zhai, Ramin Rad, Edward L Huttlin, Steven P Gygi

94) Photoactivatable CRISPR-Cas9 for optogenetic genome editing (Nature Biotechnology) Monday June 15th 2015
Yuta Nihongaki, Fuun Kawano, Takahiro Nakajima, Moritoshi Sato

95) Assembling large genomes with single-molecule sequencing and locality-sensitive hashing (Nature Biotechnology) Monday May 25th 2015
Konstantin Berlin, Sergey Koren, Chen-Shan Chin, James P Drake, Jane M Landolin, Adam M Phillippy

96) De novo assembly of a haplotype-resolved human genome (Nature Biotechnology) Monday May 25th 2015
Hongzhi Cao, Honglong Wu, Ruibang Luo, Shujia Huang, Yuhui Sun, Xin Tong, Yinlong Xie, Binghang Liu, Hailong Yang, Hancheng Zheng, Jian Li, Bo Li, Yu Wang, Fang Yang, Peng Sun, Siyang Liu, Peng Gao, Haodong Huang, Jing Sun, Dan Chen, Guangzhu He, Weihua Huang, Zheng Huang, Yue Li, Laurent C A M Tellier, Xiao Liu, Qiang Feng, Xun Xu, Xiuqing Zhang, Lars Bolund, Anders Krogh, Karsten Kristiansen, Radoje Drmanac, Snezana Drmanac, Rasmus Nielsen, Songgang Li, Jian Wang, Huanming Yang, Yingrui Li, Gane Ka-Shu Wong, Jun Wang

97) Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting (Nature Biotechnology) Monday May 25th 2015
Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel J Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Xi Kathy Zhou, Robert Edwards, Jonlin Chen, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew D Miller, Zeynep H G, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen, Steven M Lipkin

98) Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events (Nature Biotechnology) Monday May 18th 2015
Hagen Tilgner, Fereshteh Jahanbani, Tim Blauwkamp, Ali Moshrefi, Erich Jaeger, Feng Chen, Itamar Harel, Carlos D Bustamante, Morten Rasmussen, Michael P Snyder

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Mitch Andre Garcia's Chem Feeds 2008-present

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