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1) Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes (Nature Biotechnology) Monday April 14th 2014
Jason D Buenrostro, Carlos L Araya, Lauren M Chircus, Curtis J Layton, Howard Y Chang, Michael P Snyder, William J Greenleaf

2) Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal (Nature Biotechnology) Monday April 14th 2014
Thomas S Elliott, Fiona M Townsley, Ambra Bianco, Russell J Ernst, Amit Sachdeva, Simon J Els, Lloyd Davis, Kathrin Lang, Rudolf Pisa, Sebastian Greiss, Kathryn S Lilley, Jason W Chin

3) Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption (Nature Biotechnology) Monday April 7th 2014
Benjamin L Wang, Adel Ghaderi, Hang Zhou, Jeremy Agresti, David A Weitz, Gerald R Fink, Gregory Stephanopoulos

4) Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype (Nature Biotechnology) Sunday March 30th 2014
Hao Yin, Wen Xue, Sidi Chen, Roman L Bogorad, Eric Benedetti, Markus Grompe, Victor Koteliansky, Phillip A Sharp, Tyler Jacks, Daniel G Anderson

5) Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing (Nature Biotechnology) Sunday March 23rd 2014
Adam J Shuhendler, Kanyi Pu, Lina Cui, Jack P Uetrecht, Jianghong Rao

6) The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells (Nature Biotechnology) Sunday March 23rd 2014
Cole Trapnell, Davide Cacchiarelli, Jonna Grimsby, Prapti Pokharel, Shuqiang Li, Michael Morse, Niall J Lennon, Kenneth J Livak, Tarjei S Mikkelsen, John L Rinn

7) Development and function of human innate immune cells in a humanized mouse model (Nature Biotechnology) Monday March 17th 2014
Anthony Rongvaux, Tim Willinger, Jan Martinek, Till Strowig, Sofia V Gearty, Lino L Teichmann, Yasuyuki Saito, Florentina Marches, Stephanie Halene, A Karolina Palucka, Markus G Manz, Richard A Flavell

8) Massively parallel functional annotation of 3 (Nature Biotechnology) Monday March 17th 2014
Wenxue Zhao, Joshua L Pollack, Denitza P Blagev, Noah Zaitlen, Michael T McManus, David J Erle

9) Genome-guided transcript assembly by integrative analysis of RNA sequence data (Nature Biotechnology) Monday March 17th 2014
Nathan Boley, Marcus H Stoiber, Benjamin W Booth, Kenneth H Wan, Roger A Hoskins, Peter J Bickel, Susan E Celniker, James B Brown

10) CRISPR-Cas systems for editing, regulating and targeting genomes (Nature Biotechnology) Monday March 3rd 2014
Jeffry D Sander, J Keith Joung

11) Mesenchymal stem cells: immune evasive, not immune privileged (Nature Biotechnology) Sunday February 23rd 2014
James A Ankrum, Joon Faii Ong, Jeffrey M Karp

12) Whole-genome haplotyping using long reads and statistical methods (Nature Biotechnology) Sunday February 23rd 2014
Volodymyr Kuleshov, Dan Xie, Rui Chen, Dmitry Pushkarev, Zhihai Ma, Tim Blauwkamp, Michael Kertesz, Michael Snyder

13) The binary protein-protein interaction landscape of Escherichia coli (Nature Biotechnology) Sunday February 23rd 2014
Seesandra V Rajagopala, Patricia Sikorski, Ashwani Kumar, Roberto Mosca, James Vlasblom, Roland Arnold, Jonathan Franca-Koh, Suman B Pakala, Sadhna Phanse, Arnaud Ceol, Roman H, Gabriella Siszler, Stefan Wuchty, Andrew Emili, Mohan Babu, Patrick Aloy, Rembert Pieper, Peter Uetz

14) Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice (Nature Biotechnology) Sunday February 16th 2014
Shrivats Mohan Iyer, Kate L Montgomery, Chris Towne, Soo Yeun Lee, Charu Ramakrishnan, Karl Deisseroth, Scott L Delp

15) Integrating human sequence data sets provides a resource of benchmark SNP and indel genotype calls (Nature Biotechnology) Sunday February 16th 2014
Justin M Zook, Brad Chapman, Jason Wang, David Mittelman, Oliver Hofmann, Winston Hide, Marc Salit

16) Smac mimetics and innate immune stimuli synergize to promote tumor death (Nature Biotechnology) Sunday January 26th 2014
Shawn T Beug, Vera A Tang, Eric C LaCasse, Herman H Cheung, Caroline E Beauregard, Jan Brun, Jeffrey P Nuyens, Nathalie Earl, Martine St-Jean, Janelle Holbrook, Himika Dastidar, Douglas J Mahoney, Carolina Ilkow, Fabrice Le Boeuf, John C Bell, Robert G Korneluk

17) Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface (Nature Biotechnology) Sunday January 26th 2014
Steven M Lewis, Xiufeng Wu, Anna Pustilnik, Arlene Sereno, Flora Huang, Heather L Rick, Gurkan Guntas, Andrew Leaver-Fay, Eric M Smith, Carolyn Ho, Christophe Hansen-Estruch, Aaron K Chamberlain, Stephanie M Truhlar, Elaine M Conner, Shane Atwell, Brian Kuhlman, Stephen J Demarest

18) Improving CRISPR-Cas nuclease specificity using truncated guide RNAs (Nature Biotechnology) Sunday January 26th 2014
Yanfang Fu, Jeffry D Sander, Deepak Reyon, Vincent M Cascio, J Keith Joung

19) The promise and challenge of high-throughput sequencing of the antibody repertoire (Nature Biotechnology) Sunday January 19th 2014
George Georgiou, Gregory C Ippolito, John Beausang, Christian E Busse, Hedda Wardemann, Stephen R Quake

20) Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells (Nature Biotechnology) Sunday January 19th 2014
Evan W Newell, Mark M Davis

21) Single-molecule site-specific detection of protein phosphorylation with a nanopore (Nature Biotechnology) Sunday January 19th 2014
Christian B Rosen, David Rodriguez-Larrea, Hagan Bayley

22) Computational resources for high-dimensional immune analysis from the Human Immunology Project Consortium (Nature Biotechnology) Sunday January 19th 2014
Vladimir Brusic, Raphael Gottardo, Steven H Kleinstein, Mark M Davis

23) New dimensions in immunology (Nature Biotechnology) Sunday January 19th 2014


24) Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library (Nature Biotechnology) Tuesday December 24th 2013
Hiroko Koike-Yusa, Yilong Li, E-Pien Tan, Martin Del Castillo Velasco-Herrera, Kosuke Yusa

25) Genome-wide localization of small molecules (Nature Biotechnology) Sunday December 15th 2013
Lars Anders, Matthew G Guenther, Jun Qi, Zi Peng Fan, Jason J Marineau, Peter B Rahl, Jakob Lov, Alla A Sigova, William B Smith, Tong Ihn Lee, James E Bradner, Richard A Young

26) Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair (Nature Biotechnology) Sunday December 15th 2013
Paz Polak, Michael S Lawrence, Eric Haugen, Nina Stoletzki, Petar Stojanov, Robert E Thurman, Levi A Garraway, Sergei Mirkin, Gad Getz, John A Stamatoyannopoulos, Shamil R Sunyaev

27) Toxin delivery by the coat protein of an aphid-vectored plant virus provides plant resistance to aphids (Nature Biotechnology) Monday December 9th 2013
Bryony C Bonning, Narinder Pal, Sijun Liu, Zhaohui Wang, S Sivakumar, Philip M Dixon, Glenn F King, W Allen Miller

28) High-throughput genome scaffolding from in vivo DNA interaction frequency (Nature Biotechnology) Monday November 25th 2013
Noam Kaplan, Job Dekker

29) Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data (Nature Biotechnology) Monday November 25th 2013
Joshua C Denny, Lisa Bastarache, Marylyn D Ritchie, Robert J Carroll, Raquel Zink, Jonathan D Mosley, Julie R Field, Jill M Pulley, Andrea H Ramirez, Erica Bowton, Melissa A Basford, David S Carrell, Peggy L Peissig, Abel N Kho, Jennifer A Pacheco, Luke V Rasmussen, David R Crosslin, Paul K Crane, Jyotishman Pathak, Suzette J Bielinski, Sarah A Pendergrass, Hua Xu, Lucia A Hindorff, Rongling Li, Teri A Manolio, Christopher G Chute, Rex L Chisholm, Eric B Larson, Gail P Jarvik, Murray H Brilliant, Catherine A McCarty, Iftikhar J Kullo, Jonathan L Haines, Dana C Crawford, Daniel R Masys, Dan M Roden

30) Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology) Monday November 18th 2013
Luc Baeyens, Marie Lemper, Gunter Leuckx, Sofie De Groef, Paola Bonfanti, Geert Stang, Ruth Shemer, Christoffer Nord, David W Scheel, Fong C Pan, Ulf Ahlgren, Guoqiang Gu, Doris A Stoffers, Yuval Dor, Jorge Ferrer, Gerard Gradwohl, Christopher V E Wright, Mark Van de Casteele, Michael S German, Luc Bouwens, Harry Heimberg

31) Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells (Nature Biotechnology) Sunday November 10th 2013
Jeff Gole, Athurva Gore, Andrew Richards, Yu-Jui Chiu, Ho-Lim Fung, Diane Bushman, Hsin-I Chiang, Jerold Chun, Yu-Hwa Lo, Kun Zhang

32) Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions (Nature Biotechnology) Sunday November 3rd 2013
Joshua N Burton, Andrew Adey, Rupali P Patwardhan, Ruolan Qiu, Jacob O Kitzman, Jay Shendure

33) Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing (Nature Biotechnology) Sunday November 3rd 2013
Siddarth Selvaraj, Jesse R Dixon, Vikas Bansal, Bing Ren

34) Directed evolution of genetic parts and circuits by compartmentalized partnered replication (Nature Biotechnology) Sunday November 3rd 2013
Jared W Ellefson, Adam J Meyer, Randall A Hughes, Joe R Cannon, Jennifer S Brodbelt, Andrew D Ellington

35) Reassessing target antigens for adoptive T-cell therapy (Nature Biotechnology) Sunday October 20th 2013
Christian S Hinrichs, Nicholas P Restifo

36) Engineering dynamic pathway regulation using stress-response promoters (Nature Biotechnology) Sunday October 20th 2013
Robert H Dahl, Fuzhong Zhang, Jorge Alonso-Gutierrez, Edward Baidoo, Tanveer S Batth, Alyssa M Redding-Johanson, Christopher J Petzold, Aindrila Mukhopadhyay, Taek Soon Lee, Paul D Adams, Jay D Keasling

37) Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing (Nature Biotechnology) Sunday October 20th 2013
Garrett M Frampton, Alex Fichtenholtz, Geoff A Otto, Kai Wang, Sean R Downing, Jie He, Michael Schnall-Levin, Jared White, Eric M Sanford, Peter An, James Sun, Frank Juhn, Kristina Brennan, Kiel Iwanik, Ashley Maillet, Jamie Buell, Emily White, Mandy Zhao, Sohail Balasubramanian, Selmira Terzic, Tina Richards, Vera Banning, Lazaro Garcia, Kristen Mahoney, Zac Zwirko, Amy Donahue, Himisha Beltran, Juan Miguel Mosquera, Mark A Rubin, Snjezana Dogan, Cyrus V Hedvat, Michael F Berger, Lajos Pusztai, Matthias Lechner, Chris Boshoff, Mirna Jarosz, Christine Vietz, Alex Parker, Vincent A Miller, Jeffrey S Ross, John Curran, Maureen T Cronin, Philip J Stephens, Doron Lipson, Roman Yelensky

38) A single-molecule long-read survey of the human transcriptome (Nature Biotechnology) Wednesday October 9th 2013
Donald Sharon, Hagen Tilgner, Fabian Grubert, Michael Snyder

39) Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy (Nature Biotechnology) Wednesday October 9th 2013
Yicong Wu, Peter Wawrzusin, Justin Senseney, Robert S Fischer, Ryan Christensen, Anthony Santella, Andrew G York, Peter W Winter, Clare M Waterman, Zhirong Bao, Daniel A Col, Matthew McAuliffe, Hari Shroff

40) Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins (Nature Biotechnology) Wednesday October 9th 2013
Morgan L Maeder, James F Angstman, Marcy E Richardson, Samantha J Linder, Vincent M Cascio, Shengdar Q Tsai, Quan H Ho, Jeffry D Sander, Deepak Reyon, Bradley E Bernstein, Joseph F Costello, Miles F Wilkinson, J Keith Joung

41) Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1 (Nature Biotechnology) Sunday October 6th 2013
Ruijiang Song, Deena A Oren, David Franco, Michael S Seaman, David D Ho

42) Identifying producers of antibacterial compounds by screening for antibiotic resistance (Nature Biotechnology) Sunday October 6th 2013
Maulik N Thaker, Wenliang Wang, Peter Spanogiannopoulos, Nicholas Waglechner, Andrew M King, Ricardo Medina, Gerard D Wright

43) Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science (Nature Biotechnology) Sunday September 8th 2013
Paul A Guerette, Shawn Hoon, Yiqi Seow, Manfred Raida, Admir Masic, Fong T Wong, Vincent H B Ho, Kiat Whye Kong, Melik C Demirel, Abdon Pena-Francesch, Shahrouz Amini, Gavin Z Tay, Dawei Ding, Ali Miserez

44) Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction (Nature Biotechnology) Sunday September 8th 2013
Lior Zangi, Kathy O Lui, Alexander von Gise, Qing Ma, Wataru Ebina, Leon M Ptaszek, Daniela Sp, Huansheng Xu, Mohammadsharif Tabebordbar, Rostic Gorbatov, Brena Sena, Matthias Nahrendorf, David M Briscoe, Ronald A Li, Amy J Wagers, Derrick J Rossi, William T Pu, Kenneth R Chien

45) Locus-specific editing of histone modifications at endogenous enhancers (Nature Biotechnology) Sunday September 8th 2013
Eric M Mendenhall, Kaylyn E Williamson, Deepak Reyon, James Y Zou, Oren Ram, J Keith Joung, Bradley E Bernstein

46) Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences (Nature Biotechnology) Sunday August 25th 2013
Morgan G I Langille, Jesse Zaneveld, J Gregory Caporaso, Daniel McDonald, Dan Knights, Joshua A Reyes, Jose C Clemente, Deron E Burkepile, Rebecca L Vega Thurber, Rob Knight, Robert G Beiko, Curtis Huttenhower

47) Nature-inspired design of motif-specific antibody scaffolds (Nature Biotechnology) Monday August 19th 2013
James T Koerber, Nathan D Thomsen, Brett T Hannigan, William F Degrado, James A Wells

48) Conditional targeted genome editing using somatically expressed TALENs in C. elegans (Nature Biotechnology) Monday August 19th 2013
Ze Cheng, Peishan Yi, Xiangming Wang, Yongping Chai, Guoxin Feng, Yihong Yang, Xing Liang, Zhiwen Zhu, Wei Li, Guangshuo Ou

49) MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies (Nature Biotechnology) Sunday August 11th 2013
Ryan A Langlois, Randy A Albrecht, Brian Kimble, Troy Sutton, Jillian S Shapiro, Courtney Finch, Matthew Angel, Mark A Chua, Ana Silvia Gonzalez-Reiche, Kemin Xu, Daniel Perez, Adolfo Garc, Benjamin R tenOever

50) High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity (Nature Biotechnology) Sunday August 11th 2013
Vikram Pattanayak, Steven Lin, John P Guilinger, Enbo Ma, Jennifer A Doudna, David R Liu

51) Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy (Nature Biotechnology) Sunday August 11th 2013
Maria Themeli, Christopher C Kloss, Giovanni Ciriello, Victor D Fedorov, Fabiana Perna, Mithat Gonen, Michel Sadelain

52) CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering (Nature Biotechnology) Thursday August 1st 2013
Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, Sriram Kosuri, Luhan Yang, George M Church

53) Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica (Nature Biotechnology) Sunday July 21st 2013
Zhixiong Xue, Pamela L Sharpe, Seung-Pyo Hong, Narendra S Yadav, Dongming Xie, David R Short, Howard G Damude, Ross A Rupert, John E Seip, Jamie Wang, Dana W Pollak, Michael W Bostick, Melissa D Bosak, Daniel J Macool, Dieter H Hollerbach, Hongxiang Zhang, Dennis M Arcilla, Sidney A Bledsoe, Kevin Croker, Elizabeth F McCord, Bjorn D Tyreus, Ethel N Jackson, Quinn Zhu

54) Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina (Nature Biotechnology) Sunday July 21st 2013
Anai Gonzalez-Cordero, Emma L West, Rachael A Pearson, Yanai Duran, Livia S Carvalho, Colin J Chu, Arifa Naeem, Samuel J I Blackford, Anastasios Georgiadis, Jorn Lakowski, Mike Hubank, Alexander J Smith, James W B Bainbridge, Jane C Sowden, Robin R Ali

55) DNA targeting specificity of RNA-guided Cas9 nucleases (Nature Biotechnology) Sunday July 21st 2013
Patrick D Hsu, David A Scott, Joshua A Weinstein, F Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J Fine, Xuebing Wu, Ophir Shalem, Thomas J Cradick, Luciano A Marraffini, Gang Bao, Feng Zhang

56) Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments (Nature Biotechnology) Sunday July 21st 2013
Quin F Wills, Kenneth J Livak, Alex J Tipping, Tariq Enver, Andrew J Goldson, Darren W Sexton, Chris Holmes

57) Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching (Nature Biotechnology) Sunday July 21st 2013
Yu-Chan Zhang, Yang Yu, Cong-Ying Wang, Ze-Yuan Li, Qing Liu, Jie Xu, Jian-You Liao, Xiao-Jing Wang, Liang-Hu Qu, Fan Chen, Peiyong Xin, Cunyu Yan, Jinfang Chu, Hong-Qing Li, Yue-Qin Chen

58) Network link prediction by global silencing of indirect correlations (Nature Biotechnology) Sunday July 14th 2013
Baruch Barzel, Albert-L

59) Network deconvolution as a general method to distinguish direct dependencies in networks (Nature Biotechnology) Sunday July 14th 2013
Soheil Feizi, Daniel Marbach, Muriel M, Manolis Kellis

60) Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies (Nature Biotechnology) Sunday July 7th 2013
Christoph Spiess, Mark Merchant, Arthur Huang, Zhong Zheng, Nai-Ying Yang, Jing Peng, Diego Ellerman, Whitney Shatz, Dorothea Reilly, Daniel G Yansura, Justin M Scheer

61) Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells (Nature Biotechnology) Sunday June 30th 2013
Mikko Taipale, Irina Krykbaeva, Luke Whitesell, Sandro Santagata, Jianming Zhang, Qingsong Liu, Nathanael S Gray, Susan Lindquist

62) Image-based analysis of lipid nanoparticle (Nature Biotechnology) Monday June 24th 2013
Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, Kevin Manygoats, Sarah Seifert, Cordula Andree, Martin St, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin Maier, Marino Zerial

63) High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells (Nature Biotechnology) Monday June 24th 2013
Yanfang Fu, Jennifer A Foden, Cyd Khayter, Morgan L Maeder, Deepak Reyon, J Keith Joung, Jeffry D Sander

64) Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling (Nature Biotechnology) Monday June 24th 2013
Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko, Emmanouil Karagiannis, Kevin Love, Delai Chen, Roberto Zoncu, Yosef Buganim, Avi Schroeder, Robert Langer, Daniel G Anderson

65) Uniform, optimal signal processing of mapped deep-sequencing data (Nature Biotechnology) Monday June 17th 2013
Vibhor Kumar, Masafumi Muratani, Nirmala Arul Rayan, Petra Kraus, Thomas Lufkin, Huck Hui Ng, Shyam Prabhakar

66) Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization (Nature Biotechnology) Sunday June 9th 2013
Evan W Newell, Natalia Sigal, Nitya Nair, Brian A Kidd, Harry B Greenberg, Mark M Davis

67) Broad protection against influenza infection by vectored immunoprophylaxis in mice (Nature Biotechnology) Sunday June 2nd 2013
Alejandro B Balazs, Jesse D Bloom, Christin M Hong, Dinesh S Rao, David Baltimore

68) Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes (Nature Biotechnology) Sunday May 26th 2013
Mads Albertsen, Philip Hugenholtz, Adam Skarshewski, K, Gene W Tyson, Per H Nielsen

69) A large synthetic peptide and phosphopeptide reference library for mass spectrometry (Nature Biotechnology) Sunday May 19th 2013
Harald Marx, Simone Lemeer, Jan Erik Schliep, Lucrece Matheron, Shabaz Mohammed, J, Matthias Mann, Albert J R Heck, Bernhard Kuster

70) TALEN-mediated editing of the mouse Y chromosome (Nature Biotechnology) Sunday May 12th 2013
Haoyi Wang, Yueh-Chiang Hu, Styliani Markoulaki, G Grant Welstead, Albert W Cheng, Chikdu S Shivalila, Tatyana Pyntikova, Daniel B Dadon, Daniel F Voytas, Adam J Bogdanove, David C Page, Rudolf Jaenisch

71) Zwitterionic hydrogels implanted in mice resist the foreign-body reaction (Nature Biotechnology) Sunday May 12th 2013
Lei Zhang, Zhiqiang Cao, Tao Bai, Louisa Carr, Jean-Rene Ella-Menye, Colleen Irvin, Buddy D Ratner, Shaoyi Jiang

72) Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay (Nature Biotechnology) Sunday April 21st 2013
Ir, Andreas Schneeweiss, Sabine Riethdorf, Albrecht Stenzinger, Anja Schillert, Vanessa Vogel, Corinna Klein, Massimo Saini, Tobias B, Markus Wallwiener, Tim Holland-Letz, Thomas H, Martin Sprick, Martina Scharpff, Frederik Marm, Hans Peter Sinn, Klaus Pantel, Wilko Weichert, Andreas Trumpp

73) Medial ganglionic eminence (Nature Biotechnology) Sunday April 21st 2013
Yan Liu, Jason P Weick, Huisheng Liu, Robert Krencik, Xiaoqing Zhang, Lixiang Ma, Guo-min Zhou, Melvin Ayala, Su-Chun Zhang

74) Identification of direct targets and modified bases of RNA cytosine methyltransferases (Nature Biotechnology) Sunday April 21st 2013
Vahid Khoddami, Bradley R Cairns

75) Transcription factor (Nature Biotechnology) Sunday April 14th 2013
Fadi J Najm, Angela M Lager, Anita Zaremba, Krysta Wyatt, Andrew V Caprariello, Daniel C Factor, Robert T Karl, Tadao Maeda, Robert H Miller, Paul J Tesar

76) Generation of oligodendroglial cells by direct lineage conversion (Nature Biotechnology) Sunday April 14th 2013
Nan Yang, J Bradley Zuchero, Henrik Ahlenius, Samuele Marro, Yi Han Ng, Thomas Vierbuchen, John S Hawkins, Richard Geissler, Ben A Barres, Marius Wernig

77) Generation of high-affinity DNA aptamers using an expanded genetic alphabet (Nature Biotechnology) Sunday April 7th 2013
Michiko Kimoto, Rie Yamashige, Ken-ichiro Matsunaga, Shigeyuki Yokoyama, Ichiro Hirao

78) Protein interaction discovery using parallel analysis of translated ORFs (PLATO) (Nature Biotechnology) Sunday March 17th 2013
Jian Zhu, H Benjamin Larman, Geng Gao, Romel Somwar, Zijuan Zhang, Uri Laserson, Alberto Ciccia, Natalya Pavlova, George Church, Wei Zhang, Santosh Kesari, Stephen J Elledge

79) Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli (Nature Biotechnology) Sunday March 17th 2013
Irit Gat-Viks, Nicolas Chevrier, Roni Wilentzik, Thomas Eisenhaure, Raktima Raychowdhury, Yael Steuerman, Alex K Shalek, Nir Hacohen, Ido Amit, Aviv Regev

80) Efficient and specific gene knockdown by small interfering RNAs produced in bacteria (Nature Biotechnology) Monday March 11th 2013
Linfeng Huang, Jingmin Jin, Padraig Deighan, Evgeny Kiner, Larry McReynolds, Judy Lieberman

81) Mutation identification by direct comparison of whole-genome sequencing data from mutant and wild-type individuals using k-mers (Nature Biotechnology) Monday March 11th 2013
Karl J V Nordstr, Maria C Albani, Geo Velikkakam James, Caroline Gutjahr, Benjamin Hartwig, Franziska Turck, Uta Paszkowski, George Coupland, Korbinian Schneeberger

82) Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo (Nature Biotechnology) Sunday March 3rd 2013
Hannes Link, Karl Kochanowski, Uwe Sauer

83) A community-driven global reconstruction of human metabolism (Nature Biotechnology) Sunday March 3rd 2013
Ines Thiele, Neil Swainston, Ronan M T Fleming, Andreas Hoppe, Swagatika Sahoo, Maike K Aurich, Hulda Haraldsdottir, Monica L Mo, Ottar Rolfsson, Miranda D Stobbe, Stefan G Thorleifsson, Rasmus Agren, Christian B, Sergio Bordel, Arvind K Chavali, Paul Dobson, Warwick B Dunn, Lukas Endler, David Hala, Michael Hucka, Duncan Hull, Daniel Jameson, Neema Jamshidi, Jon J Jonsson, Nick Juty, Sarah Keating, Intawat Nookaew, Nicolas Le Nov, Naglis Malys, Alexander Mazein, Jason A Papin, Nathan D Price, Evgeni Selkov, Martin I Sigurdsson, Evangelos Simeonidis, Nikolaus Sonnenschein, Kieran Smallbone, Anatoly Sorokin, Johannes H G M van Beek, Dieter Weichart, Igor Goryanin, Jens Nielsen, Hans V Westerhoff, Douglas B Kell, Pedro Mendes, Bernhard

84) Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols (Nature Biotechnology) Sunday February 17th 2013
Jos, Gerald R Fink, Gregory Stephanopoulos

85) A library of TAL effector nucleases spanning the human genome (Nature Biotechnology) Sunday February 17th 2013
Yongsub Kim, Jiyeon Kweon, Annie Kim, Jae Kyung Chon, Ji Yeon Yoo, Hye Joo Kim, Sojung Kim, Choongil Lee, Euihwan Jeong, Eugene Chung, Doyoung Kim, Mi Seon Lee, Eun Mi Go, Hye Jung Song, Hwangbeom Kim, Namjin Cho, Duhee Bang, Seokjoong Kim, Jin-Soo Kim

86) Synthetic circuits integrating logic and memory in living cells (Nature Biotechnology) Sunday February 10th 2013
Piro Siuti, John Yazbek, Timothy K Lu

87) Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples (Nature Biotechnology) Sunday February 10th 2013
Kristian Cibulskis, Michael S Lawrence, Scott L Carter, Andrey Sivachenko, David Jaffe, Carrie Sougnez, Stacey Gabriel, Matthew Meyerson, Eric S Lander, Gad Getz

88) Unfoldase-mediated protein translocation through an (Nature Biotechnology) Sunday February 3rd 2013
Jeff Nivala, Douglas B Marks, Mark Akeson

89) Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (Nature Biotechnology) Tuesday January 29th 2013
Seung Woo Cho, Sojung Kim, Jong Min Kim, Jin-Soo Kim

90) Efficient genome editing in zebrafish using a CRISPR-Cas system (Nature Biotechnology) Tuesday January 29th 2013
Woong Y Hwang, Yanfang Fu, Deepak Reyon, Morgan L Maeder, Shengdar Q Tsai, Jeffry D Sander, Randall T Peterson, J-R Joanna Yeh, J Keith Joung

91) RNA-guided editing of bacterial genomes using CRISPR-Cas systems (Nature Biotechnology) Tuesday January 29th 2013
Wenyan Jiang, David Bikard, David Cox, Feng Zhang, Luciano A Marraffini

92) Single-base resolution methylomes of tomato fruit development reveal epigenome modifications associated with ripening (Nature Biotechnology) Sunday January 27th 2013
Silin Zhong, Zhangjun Fei, Yun-Ru Chen, Yi Zheng, Mingyun Huang, Julia Vrebalov, Ryan McQuinn, Nigel Gapper, Bao Liu, Jenny Xiang, Ying Shao, James J Giovannoni

93) Evaluation of methods for modeling transcription factor sequence specificity (Nature Biotechnology) Sunday January 27th 2013
Matthew T Weirauch, Atina Cote, Raquel Norel, Matti Annala, Yue Zhao, Todd R Riley, Julio Saez-Rodriguez, Thomas Cokelaer, Anastasia Vedenko, Shaheynoor Talukder, Phaedra Agius, Aaron Arvey, Philipp Bucher, Curtis G Callan, Cheng Wei Chang, Chien-Yu Chen, Yong-Syuan Chen, Yu-Wei Chu, Jan Grau, Ivo Grosse, Vidhya Jagannathan, Jens Keilwagen, Szymon M Kie, Justin B Kinney, Holger Klein, Miron B Kursa, Harri L, Kirsti Laurila, Chengwei Lei, Christina Leslie, Chaim Linhart, Anand Murugan, Alena My, William Stafford Noble, Matti Nykter, Yaron Orenstein, Stefan Posch, Jianhua Ruan, Witold R Rudnicki, Christoph D Schmid, Ron Shamir, Wing-Kin Sung, Martin Vingron, Zhizhuo Zhang, Harmen J Bussemaker, Quaid D Morris, Martha L Bulyk, Gustavo Stolovitzky, Timothy R Hughes

94) Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis (Nature Biotechnology) Sunday January 20th 2013
Yun Liu, Martin J Aryee, Leonid Padyukov, M Daniele Fallin, Espen Hesselberg, Arni Runarsson, Lovisa Reinius, Nathalie Acevedo, Margaret Taub, Marcus Ronninger, Klementy Shchetynsky, Annika Scheynius, Juha Kere, Lars Alfredsson, Lars Klareskog, Tomas J Ekstr, Andrew P Feinberg

95) High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire (Nature Biotechnology) Sunday January 20th 2013
Brandon J DeKosky, Gregory C Ippolito, Ryan P Deschner, Jason J Lavinder, Yariv Wine, Brandon M Rawlings, Navin Varadarajan, Claudia Giesecke, Thomas D, Sarah F Andrews, Patrick C Wilson, Scott P Hunicke-Smith, C Grant Willson, Andrew D Ellington, George Georgiou

96) Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs (Nature Biotechnology) Sunday January 20th 2013
Dokyun Na, Seung Min Yoo, Hannah Chung, Hyegwon Park, Jin Hwan Park, Sang Yup Lee

97) Targeted zwitterionic near-infrared fluorophores for improved optical imaging (Nature Biotechnology) Thursday December 27th 2012
Hak Soo Choi, Summer L Gibbs, Jeong Heon Lee, Soon Hee Kim, Yoshitomo Ashitate, Fangbing Liu, Hoon Hyun, GwangLi Park, Yang Xie, Soochan Bae, Maged Henary, John V Frangioni

98) Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production (Nature Biotechnology) Thursday December 27th 2012
Mark P Brynildsen, Jonathan A Winkler, Catherine S Spina, I Cody MacDonald, James J Collins

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