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1) Fast search of thousands of short-read sequencing experiments (Nature Biotechnology) Monday February 8th 2016
Brad Solomon, Carl Kingsford

2) Haplotyping germline and cancer genomes with high-throughput linked-read sequencing (Nature Biotechnology) Monday February 1st 2016
Grace X Y Zheng, Billy T Lau, Michael Schnall-Levin, Mirna Jarosz, John M Bell, Christopher M Hindson, Sofia Kyriazopoulou-Panagiotopoulou, Donald A Masquelier, Landon Merrill, Jessica M Terry, Patrice A Mudivarti, Paul W Wyatt, Rajiv Bharadwaj, Anthony J Makarewicz, Yuan Li, Phillip Belgrader, Andrew D Price, Adam J Lowe, Patrick Marks, Gerard M Vurens, Paul Hardenbol, Luz Montesclaros, Melissa Luo, Lawrence Greenfield, Alexander Wong, David E Birch, Steven W Short, Keith P Bjornson, Pranav Patel, Erik S Hopmans, Christina Wood, Sukhvinder Kaur, Glenn K Lockwood, David Stafford, Joshua P Delaney, Indira Wu, Heather S Ordonez, Susan M Grimes, Stephanie Greer, Josephine Y Lee, Kamila Belhocine, Kristina M Giorda, William H Heaton, Geoffrey P McDermott, Zachary W Bent, Francesca Meschi, Nikola O Kondov, Ryan Wilson, Jorge A Bernate, Shawn Gauby, Alex Kindwall, Clara Bermejo, Adrian N Fehr, Adrian Chan, Serge Saxonov, Kevin D Ness, Benjamin J Hindson, Hanlee P Ji

3) Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain (Nature Biotechnology) Monday February 1st 2016
Benjamin E Deverman, Piers L Pravdo, Bryan P Simpson, Sripriya Ravindra Kumar, Ken Y Chan, Abhik Banerjee, Wei-Li Wu, Bin Yang, Nina Huber, Sergiu P Pasca, Viviana Gradinaru

4) A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice (Nature Biotechnology) Monday February 1st 2016
Yang Yang, Lili Wang, Peter Bell, Deirdre McMenamin, Zhenning He, John White, Hongwei Yu, Chenyu Xu, Hiroki Morizono, Kiran Musunuru, Mark L Batshaw, James M Wilson

5) Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo (Nature Biotechnology) Monday February 1st 2016
Hao Yin, Chun-Qing Song, Joseph R Dorkin, Lihua J Zhu, Yingxiang Li, Qiongqiong Wu, Angela Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet F Bolukbasi, Stephen Walsh, Roman L Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A Wolfe, Robert Langer, Wen Xue, Daniel G Anderson

6) High-throughput mapping of regulatory DNA (Nature Biotechnology) Monday January 25th 2016
Nisha Rajagopal, Sharanya Srinivasan, Kameron Kooshesh, Yuchun Guo, Matthew D Edwards, Budhaditya Banerjee, Tahin Syed, Bart J M Emons, David K Gifford, Richard I Sherwood

7) Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates (Nature Biotechnology) Monday January 25th 2016
Arturo J Vegas, Omid Veiseh, Joshua C Doloff, Minglin Ma, Hok Hei Tam, Kaitlin Bratlie, Jie Li, Andrew R Bader, Erin Langan, Karsten Olejnik, Patrick Fenton, Jeon Woong Kang, Jennifer Hollister-Locke, Matthew A Bochenek, Alan Chiu, Sean Siebert, Katherine Tang, Siddharth Jhunjhunwala, Stephanie Aresta-Dasilva, Nimit Dholakia, Raj Thakrar, Thema Vietti, Michael Chen, Josh Cohen, Karolina Siniakowicz, Meirigeng Qi, James McGarrigle, Stephen Lyle, David M Harlan, Dale L Greiner, Jose Oberholzer, Gordon C Weir, Robert Langer, Daniel G Anderson

8) Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA (Nature Biotechnology) Wednesday January 20th 2016
Christopher D Richardson, Graham J Ray, Mark A DeWitt, Gemma L Curie, Jacob E Corn

9) Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 (Nature Biotechnology) Monday January 18th 2016
John G Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W Vaimberg, Katherine F Donovan, Ian Smith, Zuzana Tothova, Craig Wilen, Robert Orchard, Herbert W Virgin, Jennifer Listgarten, David E Root

10) Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9 (Nature Biotechnology) Monday January 18th 2016
Gozde Korkmaz, Rui Lopes, Alejandro P Ugalde, Ekaterina Nevedomskaya, Ruiqi Han, Ksenia Myacheva, Wilbert Zwart, Ran Elkon, Reuven Agami

11) Antisense oligonucleotide (Nature Biotechnology) Monday December 21st 2015
Tomoki T Nomakuchi, Frank Rigo, Isabel Aznarez, Adrian R Krainer

12) Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes (Nature Biotechnology) Monday December 21st 2015
J, Amit Zeisel, Zolt, Daniela Calvigioni, Yuchio Yanagawa, G, Sten Linnarsson, Tibor Harkany

13) Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines (Nature Biotechnology) Monday December 21st 2015
Jungseog Kang, Chien-Hsiang Hsu, Qi Wu, Shanshan Liu, Adam D Coster, Bruce A Posner, Steven J Altschuler, Lani F Wu

14) Synthetic long-read sequencing reveals intraspecies diversity in the human microbiome (Nature Biotechnology) Monday December 21st 2015
Volodymyr Kuleshov, Chao Jiang, Wenyu Zhou, Fereshteh Jahanbani, Serafim Batzoglou, Michael Snyder

15) Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq (Nature Biotechnology) Monday December 21st 2015
Cathryn R Cadwell, Athanasia Palasantza, Xiaolong Jiang, Philipp Berens, Qiaolin Deng, Marlene Yilmaz, Jacob Reimer, Shan Shen, Matthias Bethge, Kimberley F Tolias, Rickard Sandberg, Andreas S Tolias

16) Generation of serotonin neurons from human pluripotent stem cells (Nature Biotechnology) Monday December 21st 2015
Jianfeng Lu, Xuefei Zhong, Huisheng Liu, Ling Hao, Cindy Tzu-Ling Huang, Mohammad Amin Sherafat, Jeffrey Jones, Melvin Ayala, Lingjun Li, Su-Chun Zhang

17) A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae (Nature Biotechnology) Monday December 7th 2015
Andrew Hammond, Roberto Galizi, Kyros Kyrou, Alekos Simoni, Carla Siniscalchi, Dimitris Katsanos, Matthew Gribble, Dean Baker, Eric Marois, Steven Russell, Austin Burt, Nikolai Windbichler, Andrea Crisanti, Tony Nolan

18) The quantitative and condition-dependent Escherichia coli proteome (Nature Biotechnology) Monday December 7th 2015
Alexander Schmidt, Karl Kochanowski, Silke Vedelaar, Erik Ahrn, Benjamin Volkmer, Luciano Callipo, K, Manuel Bauer, Ruedi Aebersold, Matthias Heinemann

19) Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus (Nature Biotechnology) Monday December 7th 2015
Kristin M Whitworth, Raymond R R Rowland, Catherine L Ewen, Benjamin R Trible, Maureen A Kerrigan, Ada G Cino-Ozuna, Melissa S Samuel, Jonathan E Lightner, David G McLaren, Alan J Mileham, Kevin D Wells, Randall S Prather

20) Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity (Nature Biotechnology) Monday November 30th 2015
Matthew T Chang, Saurabh Asthana, Sizhi Paul Gao, Byron H Lee, Jocelyn S Chapman, Cyriac Kandoth, JianJiong Gao, Nicholas D Socci, David B Solit, Adam B Olshen, Nikolaus Schultz, Barry S Taylor

21) Mapping the effects of drugs on the immune system (Nature Biotechnology) Monday November 30th 2015
Brian A Kidd, Aleksandra Wroblewska, Mary R Boland, Judith Agudo, Miriam Merad, Nicholas P Tatonetti, Brian D Brown, Joel T Dudley

22) Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids (Nature Biotechnology) Tuesday November 17th 2015
Miriam Amiram, Adrian D Haimovich, Chenguang Fan, Yane-Shih Wang, Hans-Rudolf Aerni, Ioanna Ntai, Daniel W Moonan, Natalie J Ma, Alexis J Rovner, Seok Hoon Hong, Neil L Kelleher, Andrew L Goodman, Michael C Jewett, Dieter S, Jesse Rinehart, Farren J Isaacs

23) Safeguarding CRISPR-Cas9 gene drives in yeast (Nature Biotechnology) Tuesday November 17th 2015
James E DiCarlo, Alejandro Chavez, Sven L Dietz, Kevin M Esvelt, George M Church

24) Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors (Nature Biotechnology) Tuesday November 17th 2015
Jianbin Wang, Colin M Exline, Joshua J DeClercq, G Nicholas Llewellyn, Samuel B Hayward, Patrick Wai-Lun Li, David A Shivak, Richard T Surosky, Philip D Gregory, Michael C Holmes, Paula M Cannon

25) Comprehensive analysis of protein glycosylation by solid-phase extraction of N-linked glycans and glycosite-containing peptides (Nature Biotechnology) Tuesday November 17th 2015
Shisheng Sun, Punit Shah, Shadi Toghi Eshghi, Weiming Yang, Namita Trikannad, Shuang Yang, Lijun Chen, Paul Aiyetan, Naseruddin H, Zhen Zhang, Daniel W Chan, Hui Zhang

26) Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics (Nature Biotechnology) Tuesday November 17th 2015
Sung Il Park, Daniel S Brenner, Gunchul Shin, Clinton D Morgan, Bryan A Copits, Ha Uk Chung, Melanie Y Pullen, Kyung Nim Noh, Steve Davidson, Soong Ju Oh, Jangyeol Yoon, Kyung-In Jang, Vijay K Samineni, Megan Norman, Jose G Grajales-Reyes, Sherri K Vogt, Saranya S Sundaram, Kellie M Wilson, Jeong Sook Ha, Renxiao Xu, Taisong Pan, Tae-il Kim, Yonggang Huang, Michael C Montana, Judith P Golden, Michael R Bruchas, Robert W Gereau, John A Rogers

27) Affinity regression predicts the recognition code of nucleic acid (Nature Biotechnology) Tuesday November 17th 2015
Raphael Pelossof, Irtisha Singh, Julie L Yang, Matthew T Weirauch, Timothy R Hughes, Christina S Leslie

28) GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions (Nature Biotechnology) Monday November 2nd 2015
Judith Agudo, Albert Ruzo, Eun Sook Park, Robert Sweeney, Veronika Kana, Meng Wu, Yong Zhao, Dieter Egli, Miriam Merad, Brian D Brown

29) Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition (Nature Biotechnology) Monday November 2nd 2015
Benjamin P Kleinstiver, Michelle S Prew, Shengdar Q Tsai, Nhu T Nguyen, Ved V Topkar, Zongli Zheng, J Keith Joung

30) A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs (Nature Biotechnology) Monday October 26th 2015
Jiho Choi, Soohyun Lee, William Mallard, Kendell Clement, Guidantonio Malagoli Tagliazucchi, Hotae Lim, In Young Choi, Francesco Ferrari, Alexander M Tsankov, Ramona Pop, Gabsang Lee, John L Rinn, Alexander Meissner, Peter J Park, Konrad Hochedlinger

31) Long-term culture and expansion of primary human hepatocytes (Nature Biotechnology) Monday October 26th 2015
Gahl Levy, David Bomze, Stefan Heinz, Sarada Devi Ramachandran, Astrid Noerenberg, Merav Cohen, Oren Shibolet, Ella Sklan, Joris Braspenning, Yaakov Nahmias

32) In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity (Nature Biotechnology) Monday October 26th 2015
Geoffrey M Lynn, Richard Laga, Patricia A Darrah, Andrew S Ishizuka, Alexandra J Balaci, Andr, Michal Pechar, Robert Pola, Michael Y Gerner, Ayako Yamamoto, Connor R Buechler, Kylie M Quinn, Margery G Smelkinson, Ondrej Vanek, Ryan Cawood, Thomas Hills, Olga Vasalatiy, Kathrin Kastenm, Joseph R Francica, Lalisa Stutts, Janine K Tom, Keun Ah Ryu, Aaron P Esser-Kahn, Tomas Etrych, Kerry D Fisher, Leonard W Seymour, Robert A Seder

33) A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells (Nature Biotechnology) Monday October 26th 2015
Alexander M Tsankov, Veronika Akopian, Ramona Pop, Sundari Chetty, Casey A Gifford, Laurence Daheron, Nadejda M Tsankova, Alexander Meissner

34) Comprehensive characterization of the Published Kinase Inhibitor Set (Nature Biotechnology) Monday October 26th 2015
Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai Sepetov, Xi-Ping Huang, Bryan L Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A Teicher, Mark Kunkel, Eric Polley, Karen E Lackey, Francis L Atkinson, John P Overington, Paul Bamborough, Susanne M, Daniel J Price, Timothy M Willson, David H Drewry, Stefan Knapp, William J Zuercher

35) DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins (Nature Biotechnology) Monday October 19th 2015
Je Wook Woo, Jungeun Kim, Soon Il Kwon, Claudia Corval, Seung Woo Cho, Hyeran Kim, Sang-Gyu Kim, Sang-Tae Kim, Sunghwa Choe, Jin-Soo Kim

36) Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state (Nature Biotechnology) Monday October 12th 2015
Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Alon Goren, David A Weitz, Bradley E Bernstein

37) Nephron organoids derived from human pluripotent stem cells model kidney development and injury (Nature Biotechnology) Monday October 12th 2015
Ryuji Morizane, Albert Q Lam, Benjamin S Freedman, Seiji Kishi, M Todd Valerius, Joseph V Bonventre

38) Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease (Nature Biotechnology) Monday October 5th 2015
James E Dahlman, Omar O Abudayyeh, Julia Joung, Jonathan S Gootenberg, Feng Zhang, Silvana Konermann

39) Subangstrom single-molecule measurements of motor proteins using a nanopore (Nature Biotechnology) Tuesday September 29th 2015
Ian M Derrington, Jonathan M Craig, Eric Stava, Andrew H Laszlo, Brian C Ross, Henry Brinkerhoff, Ian C Nova, Kenji Doering, Benjamin I Tickman, Mostafa Ronaghi, Jeffrey G Mandell, Kevin L Gunderson, Jens H Gundlach

40) A catalog of the mouse gut metagenome (Nature Biotechnology) Tuesday September 29th 2015
Liang Xiao, Qiang Feng, Suisha Liang, Si Brask Sonne, Zhongkui Xia, Xinmin Qiu, Xiaoping Li, Hua Long, Jianfeng Zhang, Dongya Zhang, Chuan Liu, Zhiwei Fang, Joyce Chou, Jacob Glanville, Qin Hao, Dorota Kotowska, Camilla Colding, Tine Rask Licht, Donghai Wu, Jun Yu, Joseph Jao Yiu Sung, Qiaoyi Liang, Junhua Li, Huijue Jia, Zhou Lan, Valentina Tremaroli, Piotr Dworzynski, H Bj, Fredrik B, Jo, Emmanuelle Le Chatelier, S Dusko Ehrlich, John C Lin, Manimozhiyan Arumugam, Jun Wang, Lise Madsen, Karsten Kristiansen

41) Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering (Nature Biotechnology) Monday September 21st 2015
Dieter Blancquaert, Jeroen Van Daele, Simon Strobbe, Filip Kiekens, Sergei Storozhenko, Hans De Steur, Xavier Gellynck, Willy Lambert, Christophe Stove, Dominique Van Der Straeten

42) Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes (Nature Biotechnology) Tuesday September 15th 2015
Sachet A Shukla, Michael S Rooney, Mohini Rajasagi, Grace Tiao, Philip M Dixon, Michael S Lawrence, Jonathan Stevens, William J Lane, Jamie L Dellagatta, Scott Steelman, Carrie Sougnez, Kristian Cibulskis, Adam Kiezun, Nir Hacohen, Vladimir Brusic, Catherine J Wu, Gad Getz

43) Optogenetic control of endogenous Ca2+ channels in vivo (Nature Biotechnology) Monday September 14th 2015
Taeyoon Kyung, Sangkyu Lee, Jung Eun Kim, Taesup Cho, Hyerim Park, Yun-Mi Jeong, Dongkyu Kim, Anna Shin, Sungsoo Kim, Jinhee Baek, Jihoon Kim, Na Yeon Kim, Doyeon Woo, Sujin Chae, Cheol-Hee Kim, Hee-Sup Shin, Yong-Mahn Han, Daesoo Kim, Won Do Heo

44) Engineering pulmonary vasculature in decellularized rat and human lungs (Nature Biotechnology) Monday September 14th 2015
Xi Ren, Philipp T Moser, Sarah E Gilpin, Tatsuya Okamoto, Tong Wu, Luis F Tapias, Francois E Mercier, Linjie Xiong, Raja Ghawi, David T Scadden, Douglas J Mathisen, Harald C Ott

45) Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning (Nature Biotechnology) Monday September 14th 2015
Brian Cleary, Ilana Lauren Brito, Katherine Huang, Dirk Gevers, Terrance Shea, Sarah Young, Eric J Alm

46) De novo sequencing and variant calling with nanopores using PoreSeq (Nature Biotechnology) Thursday September 10th 2015
Tamas Szalay, Jene A Golovchenko

47) ConStrains identifies microbial strains in metagenomic datasets (Nature Biotechnology) Monday September 7th 2015
Chengwei Luo, Rob Knight, Heli Siljander, Mikael Knip, Ramnik J Xavier, Dirk Gevers

48) Massively parallel high-order combinatorial genetics in human cells (Nature Biotechnology) Monday August 17th 2015
Alan S L Wong, Gigi C G Choi, Allen A Cheng, Oliver Purcell, Timothy K Lu

49) High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics (Nature Biotechnology) Monday August 17th 2015
Sean J Humphrey, S Babak Azimifar, Matthias Mann

50) Overexpression of receptor-like kinase ERECTA improves thermotolerance in rice and tomato (Nature Biotechnology) Monday August 17th 2015
Hui Shen, Xiangbin Zhong, Fangfang Zhao, Yanmei Wang, Bingxiao Yan, Qun Li, Genyun Chen, Bizeng Mao, Jianjun Wang, Yangsheng Li, Guoying Xiao, Yuke He, Han Xiao, Jianming Li, Zuhua He

51) Prediction of human population responses to toxic compounds by a collaborative competition (Nature Biotechnology) Monday August 10th 2015
Federica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher Bare, Ruili Huang, Thea Norman, Mike Kellen, Michael P Menden, Jichen Yang, Xiaowei Zhan, Rui Zhong, Guanghua Xiao, Menghang Xia, Nour Abdo, Oksana Kosyk, Federica Eduati, Lara M Mangravite, J Christopher Bare, Thea Norman, Mike Kellen, Michael P Menden, Stephen Friend, Gustavo Stolovitzky, Allen Dearry, Raymond R Tice, Ruili Huang, Menghang Xia, Anton Simeonov, Nour Abdo, Oksana Kosyk, Ivan Rusyn, Fred A Wright, Tao Wang, Hao Tang, Xiaowei Zhan, Jichen Yang, Rui Zhong, Guanghua Xiao, Yang Xie, Hao Tang, Jichen Yang, Tao Wang, Guanghua Xiao, Yang Xie, Salvatore Alaimo, Alicia Amadoz, Muhammad Ammad-ud-din, Chlo, Jaume Bacardit, Pelham Barron, Elsa Bernard, Andreas Beyer, Shao Bin, Alena van B, Karsten Borgwardt, April M Brys, Brian Caffrey, Jeffrey Chang, Jungsoo Chang, Eleni G Christodoulou, Mathieu Cl, Trevor Cohen, Marianne Cowherd, Sofie Demeyer, Joaquin Dopazo, Joel D Elhard, Andre O Falcao, Alfredo Ferro, David A Friedenberg, Rosalba Giugno, Yunguo Gong, Jenni W Gorospe, Courtney A Granville, Dominik Grimm, Matthias Heinig, Rosa D Hernansaiz, Sepp Hochreiter, Liang-Chin Huang, Matthew Huska, Yunlong Jiao, G, Michael Kuhn, Miron Bartosz Kursa, Rintu Kutum, Nicola Lazzarini, Inhan Lee, Michael K K Leung, Weng Khong Lim, Charlie Liu, Felipe Llinares L, Alessandro Mammana, Andreas Mayr, Tom Michoel, Misael Mongiov, Jonathan D Moore, Ravi Narasimhan, Stephen O Opiyo, Gaurav Pandey, Andrea L Peabody, Juliane Perner, Alfredo Pulvirenti, Konrad Rawlik, Susanne Reinhardt, Carol G Riffle, Douglas Ruderfer, Aaron J Sander, Richard S Savage, Erwan Scornet, Patricia Sebastian-Leon, Roded Sharan, Carl Johann Simon-Gabriel, Veronique Stoven, Jingchun Sun, Hao Tang, Ana L Teixeira, Albert Tenesa, Jean-Philippe Vert, Martin Vingron, Tao Wang, Thomas Walter, Sean Whalen, Zofia Wi, Yonghui Wu, Guanghua Xiao, Yang Xie, Hua Xu, Jichen Yang, Xiaowei Zhan, Shihua Zhang, Junfei Zhao, W Jim Zheng, Rui Zhong, Dai Ziwei, Stephen Friend, Allen Dearry, Anton Simeonov, Raymond R Tice, Ivan Rusyn, Fred A Wright, Gustavo Stolovitzky, Yang Xie, Julio Saez-Rodriguez

52) Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery (Nature Biotechnology) Monday August 3rd 2015
Liliana Wroblewska, Tasuku Kitada, Kei Endo, Velia Siciliano, Breanna Stillo, Hirohide Saito, Ron Weiss

53) Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy (Nature Biotechnology) Monday August 3rd 2015
J, Masayuki Oginuma, Ziad Al Tanoury, B, Olga Sumara, Aurore Hick, Fanny Bousson, Yasmine Zidouni, Caroline Mursch, Philippe Moncuquet, Olivier Tassy, St, Ayako Miyanari, Agata Bera, Jean-Marie Garnier, Getzabel Guevara, Marie Hestin, Leif Kennedy, Shinichiro Hayashi, Bernadette Drayton, Thomas Cherrier, Barbara Gayraud-Morel, Emanuela Gussoni, Fr, Shahragim Tajbakhsh, Olivier Pourqui

54) High-throughput determination of RNA structure by proximity ligation (Nature Biotechnology) Monday August 3rd 2015
Vijay Ramani, Ruolan Qiu, Jay Shendure

55) Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning (Nature Biotechnology) Monday July 27th 2015
Babak Alipanahi, Andrew Delong, Matthew T Weirauch, Brendan J Frey

56) Engineered CHO cells for production of diverse, homogeneous glycoproteins (Nature Biotechnology) Monday July 20th 2015
Zhang Yang, Shengjun Wang, Adnan Halim, Morten Alder Schulz, Morten Frodin, Shamim H Rahman, Malene B Vester-Christensen, Carsten Behrens, Claus Kristensen, Sergey Y Vakhrushev, Eric Paul Bennett, Hans H Wandall, Henrik Clausen

57) Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells (Nature Biotechnology) Monday July 20th 2015
Matthew J Birket, Marcelo C Ribeiro, Arie O Verkerk, Dorien Ward, Ana Rita Leitoguinho, Sabine C den Hartogh, Valeria V Orlova, Harsha D Devalla, Verena Schwach, Milena Bellin, Robert Passier, Christine L Mummery

58) High-throughput sequencing of DNA G-quadruplex structures in the human genome (Nature Biotechnology) Monday July 20th 2015
Vicki S Chambers, Giovanni Marsico, Jonathan M Boutell, Marco Di Antonio, Geoffrey P Smith, Shankar Balasubramanian

59) Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown (Nature Biotechnology) Monday July 20th 2015
Anders Wittrup, Angela Ai, Xing Liu, Peter Hamar, Radiana Trifonova, Klaus Charisse, Muthiah Manoharan, Tomas Kirchhausen, Judy Lieberman

60) Directed differentiation of cholangiocytes from human pluripotent stem cells (Nature Biotechnology) Wednesday July 15th 2015
Mina Ogawa, Shinichiro Ogawa, Christine E Bear, Saumel Ahmadi, Stephanie Chin, Bin Li, Markus Grompe, Gordon Keller, Binita M Kamath, Anand Ghanekar

61) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation (Nature Biotechnology) Wednesday July 15th 2015
Fotios Sampaziotis, Miguel Cardoso de Brito, Pedro Madrigal, Alessandro Bertero, Kourosh Saeb-Parsy, Filipa A C Soares, Elisabeth Schrumpf, Espen Melum, Tom H Karlsen, J Andrew Bradley, William T H Gelson, Susan Davies, Alastair Baker, Arthur Kaser, Graeme J Alexander, Nicholas R F Hannan, Ludovic Vallier

62) Expression of trehalose-6-phosphate phosphatase in maize ears improves yield in well-watered and drought conditions (Nature Biotechnology) Monday July 6th 2015
Michael L Nuccio, Jeff Wu, Ron Mowers, Hua-Ping Zhou, Moez Meghji, Lucia F Primavesi, Matthew J Paul, Xi Chen, Yan Gao, Emdadul Haque, Shib Sankar Basu, L Mark Lagrimini

63) Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation (Nature Biotechnology) Monday June 29th 2015
Dimos Gaidatzis, Lukas Burger, Maria Florescu, Michael B Stadler

64) Kinetic fingerprinting to identify and count single nucleic acids (Nature Biotechnology) Monday June 29th 2015
Alexander Johnson-Buck, Xin Su, Maria D Giraldez, Meiping Zhao, Muneesh Tewari, Nils G Walter

65) Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells (Nature Biotechnology) Monday June 29th 2015
Ayal Hendel, Rasmus O Bak, Joseph T Clark, Andrew B Kennedy, Daniel E Ryan, Subhadeep Roy, Israel Steinfeld, Benjamin D Lunstad, Robert J Kaiser, Alec B Wilkens, Rosa Bacchetta, Anya Tsalenko, Douglas Dellinger, Laurakay Bruhn, Matthew H Porteus

66) Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage (Nature Biotechnology) Monday June 29th 2015
Ori Bar-Nur, Cassandra Verheul, Andreia G Sommer, Justin Brumbaugh, Benjamin A Schwarz, Inna Lipchina, Aaron J Huebner, Gustavo Mostoslavsky, Konrad Hochedlinger

67) Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors (Nature Biotechnology) Monday June 29th 2015
Itay Maza, Inbal Caspi, Asaf Zviran, Elad Chomsky, Yoach Rais, Sergey Viukov, Shay Geula, Jason D Buenrostro, Leehee Weinberger, Vladislav Krupalnik, Suhair Hanna, Mirie Zerbib, James R Dutton, William J Greenleaf, Rada Massarwa, Noa Novershtern, Jacob H Hanna

68) Optogenetics for in vivo cardiac pacing and resynchronization therapies (Nature Biotechnology) Monday June 29th 2015
Udi Nussinovitch, Lior Gepstein

69) Flexible guide-RNA design for CRISPR applications using Protospacer Workbench (Nature Biotechnology) Monday June 29th 2015
Cameron Ross MacPherson, Artur Scherf

70) Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index (Nature Biotechnology) Monday June 15th 2015
Robert P Lyon, Tim D Bovee, Svetlana O Doronina, Patrick J Burke, Joshua H Hunter, Haley D Neff-LaFord, Mechthild Jonas, Martha E Anderson, Jocelyn R Setter, Peter D Senter

71) A mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides (Nature Biotechnology) Monday June 15th 2015
Joel M Chick, Deepak Kolippakkam, David P Nusinow, Bo Zhai, Ramin Rad, Edward L Huttlin, Steven P Gygi

72) Photoactivatable CRISPR-Cas9 for optogenetic genome editing (Nature Biotechnology) Monday June 15th 2015
Yuta Nihongaki, Fuun Kawano, Takahiro Nakajima, Moritoshi Sato

73) Assembling large genomes with single-molecule sequencing and locality-sensitive hashing (Nature Biotechnology) Monday May 25th 2015
Konstantin Berlin, Sergey Koren, Chen-Shan Chin, James P Drake, Jane M Landolin, Adam M Phillippy

74) De novo assembly of a haplotype-resolved human genome (Nature Biotechnology) Monday May 25th 2015
Hongzhi Cao, Honglong Wu, Ruibang Luo, Shujia Huang, Yuhui Sun, Xin Tong, Yinlong Xie, Binghang Liu, Hailong Yang, Hancheng Zheng, Jian Li, Bo Li, Yu Wang, Fang Yang, Peng Sun, Siyang Liu, Peng Gao, Haodong Huang, Jing Sun, Dan Chen, Guangzhu He, Weihua Huang, Zheng Huang, Yue Li, Laurent C A M Tellier, Xiao Liu, Qiang Feng, Xun Xu, Xiuqing Zhang, Lars Bolund, Anders Krogh, Karsten Kristiansen, Radoje Drmanac, Snezana Drmanac, Rasmus Nielsen, Songgang Li, Jian Wang, Huanming Yang, Yingrui Li, Gane Ka-Shu Wong, Jun Wang

75) Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting (Nature Biotechnology) Monday May 25th 2015
Huanhuan Joyce Chen, Jian Sun, Zhiliang Huang, Harry Hou, Myra Arcilla, Nikolai Rakhilin, Daniel J Joe, Jiahn Choi, Poornima Gadamsetty, Jeff Milsom, Govind Nandakumar, Randy Longman, Xi Kathy Zhou, Robert Edwards, Jonlin Chen, Kai Yuan Chen, Pengcheng Bu, Lihua Wang, Yitian Xu, Robert Munroe, Christian Abratte, Andrew D Miller, Zeynep H G, Michael Shuler, Nozomi Nishimura, Winfried Edelmann, Xiling Shen, Steven M Lipkin

76) Comprehensive transcriptome analysis using synthetic long-read sequencing reveals molecular co-association of distant splicing events (Nature Biotechnology) Monday May 18th 2015
Hagen Tilgner, Fereshteh Jahanbani, Tim Blauwkamp, Ali Moshrefi, Erich Jaeger, Feng Chen, Itamar Harel, Carlos D Bustamante, Morten Rasmussen, Michael P Snyder

77) In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency (Nature Biotechnology) Monday May 18th 2015
Azita J Mahiny, Alexander Dewerth, Lauren E Mays, Mohammed Alkhaled, Benedikt Mothes, Emad Malaeksefat, Brigitta Loretz, Jennifer Rottenberger, Darina M Brosch, Philipp Reautschnig, Pacharapan Surapolchai, Franziska Zeyer, Andrea Schams, Melanie Carevic, Martina Bakele, Matthias Griese, Matthias Schwab, Bernd N, Sandra Beer-Hammer, Rupert Handgretinger, Dominik Hartl, Claus-Michael Lehr, Michael S D Kormann

78) Generation of articular chondrocytes from human pluripotent stem cells (Nature Biotechnology) Monday May 11th 2015
April M Craft, Jason S Rockel, Yulia Nartiss, Rita A Kandel, Benjamin A Alman, Gordon M Keller

79) Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains (Nature Biotechnology) Monday May 11th 2015
Junwei Shi, Eric Wang, Joseph P Milazzo, Zihua Wang, Justin B Kinney, Christopher R Vakoc

80) Genome sequence of cultivated Upland cotton (Gossypiumhirsutum TM-1) provides insights into genome evolution (Nature Biotechnology) Monday April 20th 2015
Fuguang Li, Guangyi Fan, Cairui Lu, Guanghui Xiao, Changsong Zou, Russell J Kohel, Zhiying Ma, Haihong Shang, Xiongfeng Ma, Jianyong Wu, Xinming Liang, Gai Huang, Richard G Percy, Kun Liu, Weihua Yang, Wenbin Chen, Xiongming Du, Chengcheng Shi, Youlu Yuan, Wuwei Ye, Xin Liu, Xueyan Zhang, Weiqing Liu, Hengling Wei, Shoujun Wei, Guodong Huang, Xianlong Zhang, Shuijin Zhu, He Zhang, Fengming Sun, Xingfen Wang, Jie Liang, Jiahao Wang, Qiang He, Leihuan Huang, Jun Wang, Jinjie Cui, Guoli Song, Kunbo Wang, Xun Xu, John Z Yu, Yuxian Zhu, Shuxun Yu

81) A prevascularized subcutaneous device-less site for islet and cellular transplantation (Nature Biotechnology) Monday April 20th 2015
Andrew R Pepper, Boris Gala-Lopez, Rena Pawlick, Shaheed Merani, Tatsuya Kin, A M James Shapiro

82) Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement (Nature Biotechnology) Monday April 20th 2015
Tianzhen Zhang, Yan Hu, Wenkai Jiang, Lei Fang, Xueying Guan, Jiedan Chen, Jinbo Zhang, Christopher A Saski, Brian E Scheffler, David M Stelly, Amanda M Hulse-Kemp, Qun Wan, Bingliang Liu, Chunxiao Liu, Sen Wang, Mengqiao Pan, Yangkun Wang, Dawei Wang, Wenxue Ye, Lijing Chang, Wenpan Zhang, Qingxin Song, Ryan C Kirkbride, Xiaoya Chen, Elizabeth Dennis, Danny J Llewellyn, Daniel G Peterson, Peggy Thaxton, Don C Jones, Qiong Wang, Xiaoyang Xu, Hua Zhang, Huaitong Wu, Lei Zhou, Gaofu Mei, Shuqi Chen, Yue Tian, Dan Xiang, Xinghe Li, Jian Ding, Qiyang Zuo, Linna Tao, Yunchao Liu, Ji Li, Yu Lin, Yuanyuan Hui, Zhisheng Cao, Caiping Cai, Xiefei Zhu, Zhi Jiang, Baoliang Zhou, Wangzhen Guo, Ruiqiang Li, Z Jeffrey Chen

83) High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin (Nature Biotechnology) Monday April 13th 2015
Kaia Achim, Jean-Baptiste Pettit, Luis R Saraiva, Daria Gavriouchkina, Tomas Larsson, Detlev Arendt, John C Marioni

84) Spatial reconstruction of single-cell gene expression data (Nature Biotechnology) Monday April 13th 2015
Rahul Satija, Jeffrey A Farrell, David Gennert, Alexander F Schier, Aviv Regev

85) Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells (Nature Biotechnology) Tuesday March 24th 2015
Van Trung Chu, Timm Weber, Benedikt Wefers, Wolfgang Wurst, Sandrine Sander, Klaus Rajewsky, Ralf K

86) Multiplexed tracking of combinatorial genomic mutations in engineered cell populations (Nature Biotechnology) Monday March 23rd 2015
Ramsey I Zeitoun, Andrew D Garst, George D Degen, Gur Pines, Thomas J Mansell, Tirzah Y Glebes, Nanette R Boyle, Ryan T Gill

87) Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells (Nature Biotechnology) Monday March 23rd 2015
Andriana G Kotini, Chan-Jung Chang, Ibrahim Boussaad, Jeffrey J Delrow, Emily K Dolezal, Abhinav B Nagulapally, Fabiana Perna, Gregory A Fishbein, Virginia M Klimek, R David Hawkins, Danwei Huangfu, Charles E Murry, Timothy Graubert, Stephen D Nimer, Eirini P Papapetrou

88) Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody (Nature Biotechnology) Monday March 23rd 2015
Laurent Mailly, Fei Xiao, Joachim Lupberger, Garrick K Wilson, Philippe Aubert, Fran, Diego Calabrese, C, Isabel Fofana, Christine Thumann, Simonetta Bandiera, Marc L, Tassilo Volz, Christopher Davis, Helen J Harris, Christopher J Mee, Erika Girardi, B, Maria Ericsson, Nicola Fletcher, Ralf Bartenschlager, Patrick Pessaux, Koen Vercauteren, Philip Meuleman, Pascal Villa, Lars Kaderali, S, Markus H Heim, Michel Neunlist, Mirjam B Zeisel, Maura Dandri, Jane A McKeating, Eric Robinet, Thomas F Baumert

89) Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining (Nature Biotechnology) Monday March 23rd 2015
Takeshi Maruyama, Stephanie K Dougan, Matthias C Truttmann, Angelina M Bilate, Jessica R Ingram, Hidde L Ploegh

90) MutMap accelerates breeding of a salt-tolerant rice cultivar (Nature Biotechnology) Monday March 23rd 2015
Hiroki Takagi, Muluneh Tamiru, Akira Abe, Kentaro Yoshida, Aiko Uemura, Hiroki Yaegashi, Tsutomu Obara, Kaori Oikawa, Hiroe Utsushi, Eiko Kanzaki, Chikako Mitsuoka, Satoshi Natsume, Shunichi Kosugi, Hiroyuki Kanzaki, Hideo Matsumura, Naoya Urasaki, Sophien Kamoun, Ryohei Terauchi

91) Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice (Nature Biotechnology) Monday March 16th 2015
Matthias Obenaus, Catarina Leit, Matthias Leisegang, Xiaojing Chen, Ioannis Gavvovidis, Pierre van der Bruggen, Wolfgang Uckert, Dolores J Schendel, Thomas Blankenstein

92) High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells (Nature Biotechnology) Monday March 16th 2015
Malte Wachsmuth, Christian Conrad, Jutta Bulkescher, Birgit Koch, Robert Mahen, Mayumi Isokane, Rainer Pepperkok, Jan Ellenberg

93) ChIP-nexus enables improved detection of in vivo transcription factor binding footprints (Nature Biotechnology) Monday March 9th 2015
Qiye He, Jeff Johnston, Julia Zeitlinger

94) Acetylation site specificities of lysine deacetylase inhibitors in human cells (Nature Biotechnology) Monday March 9th 2015
Christian Sch, Brian T Weinert, Sebastian A Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars J Jensen, Werner Streicher, Anna R McCarthy, Nicholas J Westwood, Sonia Lain, J, Patrick Matthias, Matthias Mann, James E Bradner, Chunaram Choudhary

95) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads (Nature Biotechnology) Wednesday February 18th 2015
Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg

96) C2H2 zinc finger proteins greatly expand the human regulatory lexicon (Nature Biotechnology) Wednesday February 18th 2015
Hamed S Najafabadi, Sanie Mnaimneh, Frank W Schmitges, Michael Garton, Kathy N Lam, Ally Yang, Mihai Albu, Matthew T Weirauch, Ernest Radovani, Philip M Kim, Jack Greenblatt, Brendan J Frey, Timothy R Hughes

97) Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues (Nature Biotechnology) Wednesday February 18th 2015
Jason Ernst, Manolis Kellis

98) Epigenomic annotation of genetic variants using the Roadmap Epigenome Browser (Nature Biotechnology) Wednesday February 18th 2015
Xin Zhou, Daofeng Li, Bo Zhang, Rebecca F Lowdon, Nicole B Rockweiler, Renee L Sears, Pamela A F Madden, Ivan Smirnov, Joseph F Costello, Ting Wang

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Mitch Andre Garcia's Chem Feeds 2008-present

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