1) Vaccine Delivery by Polymeric Vehicles in the Mouse Reproductive Tract Induces Sustained Local and Systemic Immunity (Molecular Pharmaceutics) Friday August 27th 2010 2) Virtual Screening of Selective Multitarget Kinase Inhibitors by Combinatorial Support Vector Machines (Molecular Pharmaceutics) Friday August 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 3) Evolutionary Selection of New Breast Cancer Cell-Targeting Peptides and Phages with the Cell-Targeting Peptides Fully Displayed on the Major Coat and Their Effects on Actin Dynamics during Cell Internalization (Molecular Pharmaceutics) Thursday August 26th 2010 4) The Antitumoral Depsipeptide IB-01212 Kills Leishmania through an Apoptosis-like Process Involving Intracellular Targets (Molecular Pharmaceutics) Wednesday August 18th 2010 5) Effects of PEGylation and Acetylation of PAMAM Dendrimers on DNA Binding, Cytotoxicity and in Vitro Transfection Efficiency (Molecular Pharmaceutics) Wednesday August 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 6) A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling (Molecular Pharmaceutics) Wednesday August 18th 2010 7) Immunoliposomes That Target Endothelium In Vitro Are Dependent on Lipid Raft Formation (Molecular Pharmaceutics) Wednesday August 18th 2010 8) Interaction of Poly(glycoamidoamine) DNA Delivery Vehicles with Cell-Surface Glycosaminoglycans Leads to Polyplex Internalization in a Manner Not Solely Dependent on Charge (Molecular Pharmaceutics) Tuesday August 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 9) Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption (Molecular Pharmaceutics) Friday August 13th 2010 10) Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo Absorption (Molecular Pharmaceutics) Friday August 13th 2010 11) Dissolution Modeling of Bead Formulations and Predictions of Bioequivalence for a Highly Soluble, Highly Permeable Drug (Molecular Pharmaceutics) Friday August 13th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 12) Nanoparticles Based on PLGA:Poloxamer Blends for the Delivery of Proangiogenic Growth Factors (Molecular Pharmaceutics) Friday August 13th 2010 13) Development and Evaluation of a Novel Method for Preclinical Measurement of Tissue Vascular Volume (Molecular Pharmaceutics) Friday August 13th 2010 14) A New Intestinal Cell Culture Model To Discriminate the Relative Contribution of P-gp and BCRP on Transport of Substrates Such as Imatinib (Molecular Pharmaceutics) Thursday August 12th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 15) Efficient Delivery of Payload into Tumor Cells in a Controlled Manner by TAT and Thiolytic Cleavable PEG Co-Modified Liposomes (Molecular Pharmaceutics) Thursday August 12th 2010 16) Dynamic Dissolution: A Step Closer to Predictive Dissolution Testing? (Molecular Pharmaceutics) Wednesday August 11th 2010 17) Aqueous Boundary Layers Related to Oral Absorption of a Drug: From Dissolution of a Drug to Carrier Mediated Transport and Intestinal Wall Metabolism (Molecular Pharmaceutics) Tuesday August 10th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 18) Transnasal Delivery of Methotrexate to Brain Tumors in Rats: A New Strategy for Brain Tumor Chemotherapy (Molecular Pharmaceutics) Tuesday August 10th 2010 19) Effect of Variations in the Amounts of P-Glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the Human Small Intestine on PBPK Models for Predicting Intestinal First Pass (Molecular Pharmaceutics) Thursday August 5th 2010 20) Simultaneous Release and ADME Processes of Poorly Water-Soluble Drugs: Mathematical Modeling (Molecular Pharmaceutics) Wednesday August 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 21) Analysis of Amorphous Solid Dispersions Using 2D Solid-State NMR and 1H T1 Relaxation Measurements (Molecular Pharmaceutics) Wednesday August 4th 2010 22) XIAP Gene Expression Protects β-Cells and Human Islets from Apoptotic Cell Death (Molecular Pharmaceutics) Tuesday August 3rd 2010 23) Study of the Amorphous Glibenclamide Drug: Analysis of the Molecular Dynamics of Quenched and Cryomilled Material (Molecular Pharmaceutics) Friday July 30th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 24) Use of Artificial Stomach−Duodenum Model for Investigation of Dosing Fluid Effect on Clinical Trial Variability (Molecular Pharmaceutics) Friday July 30th 2010 25) Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery (Molecular Pharmaceutics) Friday July 30th 2010 26) MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells (Molecular Pharmaceutics) Friday July 30th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 27) Sodium N-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use (Molecular Pharmaceutics) Wednesday July 28th 2010 28) Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance (Molecular Pharmaceutics) Wednesday July 28th 2010 29) Thermoresponsive Hydrogel as a Delivery Scaffold for Transfected Rat Mesenchymal Stem Cells (Molecular Pharmaceutics) Tuesday July 20th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 30) Iodinated NanoClusters as an Inhaled Computed Tomography Contrast Agent for Lung Visualization (Molecular Pharmaceutics) Friday July 16th 2010 31) Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir (Molecular Pharmaceutics) Friday July 16th 2010 32) Silk-Elastin-like Hydrogel Improves the Safety of Adenovirus-Mediated Gene-Directed Enzyme−Prodrug Therapy (Molecular Pharmaceutics) Friday July 16th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 33) Specific Detection of Gastric α-Antitrypsin by Immobilized Trypsin on PolyHEMA Films (Molecular Pharmaceutics) Friday July 9th 2010 34) Importance of Avidity for an Endogenous Drug Carrier: An Antibody Carrier for CpG Oligonucleotides (Molecular Pharmaceutics) Thursday July 8th 2010 35) Effect of Cholesterol Nanodomains on the Targeting of Lipid-Based Gene Delivery in Cultured Cells (Molecular Pharmaceutics) Thursday July 8th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 36) ABC and SLC Transporter Expression and Pot Substrate Characterization across the Human CMEC/D3 Blood−Brain Barrier Cell Line (Molecular Pharmaceutics) Wednesday July 7th 2010 37) Silencing Heat Shock Protein 27 Decreases Metastatic Behavior of Human Head and Neck Squamous Cell Cancer Cells in Vitro (Molecular Pharmaceutics) Wednesday July 7th 2010 38) Boosting Oncolytic Adenovirus Potency with Magnetic Nanoparticles and Magnetic Force (Molecular Pharmaceutics) Saturday July 3rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 39) Synergistic Action of Doxorubicin Bound to the Polymeric Carrier Based on N-(2-Hydroxypropyl)methacrylamide Copolymers through an Amide or Hydrazone Bond (Molecular Pharmaceutics) Friday July 2nd 2010 40) Pharmacokinetic and Biodistribution Studies of N-(2-Hydroxypropyl)methacrylamide Copolymer-Dexamethasone Conjugates in Adjuvant-Induced Arthritis Rat Model (Molecular Pharmaceutics) Friday July 2nd 2010 41) Enhanced Stability of PEG-block-poly(N-hexyl stearate l-aspartamide) Micelles in the Presence of Serum Proteins (Molecular Pharmaceutics) Thursday July 1st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 42) Uptake, Distribution and Diffusivity of Reactive Fluorophores in Cells: Implications toward Target Identification (Molecular Pharmaceutics) Thursday July 1st 2010 43) Cytochrome c Encapsulating Theranostic Nanoparticles: A Novel Bifunctional System for Targeted Delivery of Therapeutic Membrane-Impermeable Proteins to Tumors and Imaging of Cancer Therapy (Molecular Pharmaceutics) Wednesday June 30th 2010 44) Biological Assessment of Triazine Dendrimer: Toxicological Profiles, Solution Behavior, Biodistribution, Drug Release and Efficacy in a PEGylated, Paclitaxel Construct (Molecular Pharmaceutics) Wednesday June 30th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 45) The Biowaiver Extension for BCS Class III Drugs: The Effect of Dissolution Rate on the Bioequivalence of BCS Class III Immediate-Release Drugs Predicted by Computer Simulation (Molecular Pharmaceutics) Tuesday June 29th 2010 46) Evaluation of the Microstructure of Semicrystalline Solid Dispersions (Molecular Pharmaceutics) Tuesday June 29th 2010 47) Small Scale Screening To Determine the Ability of Different Polymers To Inhibit Drug Crystallization upon Rapid Solvent Evaporation (Molecular Pharmaceutics) Friday June 25th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 48) Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media (Molecular Pharmaceutics) Friday June 25th 2010 49) Uptake of Microemulsion Components into the Stratum Corneum and Their Molecular Effects on Skin Barrier Function (Molecular Pharmaceutics) Wednesday June 23rd 2010 50) Investigation of the Effect of Mutations of Rat Albumin on the Binding Affinity to the α4β1 Integrin Antagonist, 4-[1-[3-Chloro-4-[N′-(2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidine-2-yl]methoxybenzoic Acid (D01-4582), Using Recombinant Rat Albumins (Molecular Pharmaceutics) Wednesday June 23rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 51) Cyclosporin A-Loaded Poly(ethylene glycol)-b-poly(d,l-lactic acid) Micelles: Preparation, in Vitro and in Vivo Characterization and Transport Mechanism across the Intestinal Barrier (Molecular Pharmaceutics) Wednesday June 23rd 2010 52) Inclusion Complex of a Bcl-2 Inhibitor with Cyclodextrin: Characterization, Cellular Accumulation, and in Vivo Antitumor Activity (Molecular Pharmaceutics) Wednesday June 23rd 2010 53) Theoretical and Experimental Investigation on the Solid Solubility and Miscibility of Naproxen in Poly(vinylpyrrolidone) (Molecular Pharmaceutics) Tuesday June 22nd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 54) Affinity Enhancement Pretargeting: Synthesis and Testing of a 99mTc-Labeled Bivalent MORF (Molecular Pharmaceutics) Tuesday June 22nd 2010 55) Interfacial Activity Assisted Surface Functionalization: A Novel Approach To Incorporate Maleimide Functional Groups and cRGD Peptide on Polymeric Nanoparticles for Targeted Drug Delivery (Molecular Pharmaceutics) Saturday June 19th 2010 56) Anionic Amino Acid Dendrimer−Trastuzumab Conjugates for Specific Internalization in HER2-Positive Cancer Cells (Molecular Pharmaceutics) Saturday June 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 57) Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity (Molecular Pharmaceutics) Saturday June 19th 2010 58) Protein Modification with Amphiphilic Block Copoly(2-oxazoline)s as a New Platform for Enhanced Cellular Delivery (Molecular Pharmaceutics) Wednesday June 16th 2010 59) Cytoplasmic Delivery of Liposomes into MCF-7 Breast Cancer Cells Mediated by Cell-Specific Phage Fusion Coat Protein (Molecular Pharmaceutics) Tuesday June 15th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 60) A Novel Octreotide Modified Lipid Vesicle Improved the Anticancer Efficacy of Doxorubicin in Somatostatin Receptor 2 Positive Tumor Models (Molecular Pharmaceutics) Tuesday June 15th 2010 61) HPMA Copolymer Conjugates of Paclitaxel and Docetaxel with pH-Controlled Drug Release (Molecular Pharmaceutics) Friday June 11th 2010 62) Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity (Molecular Pharmaceutics) Friday June 11th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 63) Polymeric Nanoparticles Containing Conjugated Phospholipase A2 for Nonviral Gene Delivery (Molecular Pharmaceutics) Wednesday June 9th 2010 64) Positive Feedback System Provides Efficient and Persistent Transgene Expression (Molecular Pharmaceutics) Wednesday June 9th 2010 65) A Truncated HGP Peptide Sequence That Retains Endosomolytic Activity and Improves Gene Delivery Efficiencies (Molecular Pharmaceutics) Friday June 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 66) Uptake of Pramipexole by Human Organic Cation Transporters (Molecular Pharmaceutics) Friday June 4th 2010 67) An Effective Targeted Nanoglobular Manganese(II) Chelate Conjugate for Magnetic Resonance Molecular Imaging of Tumor Extracellular Matrix (Molecular Pharmaceutics) Wednesday June 2nd 2010 68) A Novel Poly(l-glutamic acid) Dendrimer Based Drug Delivery System with Both pH-Sensitive and Targeting Functions (Molecular Pharmaceutics) Saturday May 29th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 69) Reduced Skin Photosensitivity with meta-Tetra(hydroxyphenyl)chlorin-Loaded Micelles Based on a Poly(2-ethyl-2-oxazoline)-b-poly(d,l-lactide) Diblock Copolymer in Vivo (Molecular Pharmaceutics) Saturday May 29th 2010 70) The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles (Molecular Pharmaceutics) Thursday May 27th 2010 71) In Vivo Evaluation of pH-Sensitive Polymer-Based Immunoliposomes Targeting the CD33 Antigen (Molecular Pharmaceutics) Thursday May 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 72) Lipopolysaccharide-QD Micelles Induce Marked Induction of TLR2 and Lipid Droplet Accumulation in Olfactory Bulb Microglia (Molecular Pharmaceutics) Saturday May 22nd 2010 73) Crystallization of Amorphous Indomethacin during Dissolution: Effect of Processing and Annealing (Molecular Pharmaceutics) Saturday May 22nd 2010 74) Thermally Controlled Intracellular Uptake System of Polymeric Micelles Possessing Poly(N-isopropylacrylamide)-Based Outer Coronas (Molecular Pharmaceutics) Wednesday May 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 75) Toxicity Pathway Focused Gene Expression Profiling of PEI-Based Polymers for Pulmonary Applications (Molecular Pharmaceutics) Saturday May 15th 2010 76) Improved Extrapolation of Hepatobiliary Clearance from in Vitro Sandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters (Molecular Pharmaceutics) Friday May 14th 2010 77) Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures (Molecular Pharmaceutics) Tuesday May 11th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 78) Poly(glycoamidoamine) Vehicles Promote pDNA Uptake through Multiple Routes and Efficient Gene Expression via Caveolae-Mediated Endocytosis (Molecular Pharmaceutics) Saturday May 8th 2010 79) Paclitaxel Nanocrystals for Overcoming Multidrug Resistance in Cancer (Molecular Pharmaceutics) Saturday May 8th 2010 80) In Silico Identification of the Potential Drug Resistance Sites over 2009 Influenza A (H1N1) Virus Neuraminidase (Molecular Pharmaceutics) Thursday May 6th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 81) Diabetes Correction in Pancreatectomized Canines by Orally Absorbable Insulin−Deoxycholate Complex (Molecular Pharmaceutics) Tuesday May 4th 2010 82) Evaluating the Gene-Expression Profiles of HeLa Cancer Cells Treated with Activated and Nonactivated Poly(amidoamine) Dendrimers, and Their DNA Complexes (Molecular Pharmaceutics) Wednesday April 28th 2010 83) Dendrimer Internalization and Intracellular Trafficking in Living Cells (Molecular Pharmaceutics) Wednesday April 28th 2010 0 comments, related, 6 Up Votes 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 84) Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells (Molecular Pharmaceutics) Tuesday April 27th 2010 85) Vitamin E TPGS P-Glycoprotein Inhibition Mechanism: Influence on Conformational Flexibility, Intracellular ATP Levels, and Role of Time and Site of Access (Molecular Pharmaceutics) Friday April 23rd 2010 86) Use of Glucuronidation Fingerprinting To Describe and Predict Mono- and Dihydroxyflavone Metabolism by Recombinant UGT Isoforms and Human Intestinal and Liver Microsomes (Molecular Pharmaceutics) Tuesday April 20th 2010 0 comments, related, 2 Up Votes 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 87) Topical Delivery of Interferon Alpha by Biphasic Vesicles: Evidence for a Novel Nanopathway across the Stratum Corneum (Molecular Pharmaceutics) Saturday April 17th 2010 88) Polycation-Induced Cell Membrane Permeability Does Not Enhance Cellular Uptake or Expression Efficiency of Delivered DNA (Molecular Pharmaceutics) Friday April 16th 2010 89) Predicting the Formation and Stability of Amorphous Small Molecule Binary Mixtures from Computationally Determined Flory−Huggins Interaction Parameter and Phase Diagram (Molecular Pharmaceutics) Wednesday April 14th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 90) Nanoscaled Polyion Complex Micelles for Targeted Delivery of Recombinant Hirudin to Platelets Based on Cationic Copolymer (Molecular Pharmaceutics) Wednesday April 14th 2010 91) The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by in Vivo Imaging (Molecular Pharmaceutics) Saturday April 10th 2010 92) Anticoagulant Efficacy of Solid Oral Formulations Containing a New Heparin Derivative (Molecular Pharmaceutics) Saturday April 10th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 2 comments, related, 1 Up Vote 93) Development of a Novel Self-Microemulsifying Drug Delivery System for Reducing HIV Protease Inhibitor-Induced Intestinal Epithelial Barrier Dysfunction (Molecular Pharmaceutics) Thursday April 8th 2010 94) Intracellular Delivery of the Reactive Oxygen Species Generating Agent d-Penicillamine upon Conjugation to Poly-l-glutamic Acid (Molecular Pharmaceutics) Wednesday April 7th 2010 95) ApoE3 Mediated Poly(butyl) Cyanoacrylate Nanoparticles Containing Curcumin: Study of Enhanced Activity of Curcumin against Beta Amyloid Induced Cytotoxicity Using In Vitro Cell Culture Model (Molecular Pharmaceutics) Tuesday April 6th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 96) In Vitro Analysis of Acetalated Dextran Microparticles as a Potent Delivery Platform for Vaccine Adjuvants (Molecular Pharmaceutics) Friday April 2nd 2010 97) Nitric Oxide-Releasing Silica Nanoparticle Inhibition of Ovarian Cancer Cell Growth (Molecular Pharmaceutics) Friday April 2nd 2010 98) Effect of Anabolic−Androgenic Steroids and Glucocorticoids on the Kinetics of hAR and hGR Nucleocytoplasmic Translocation (Molecular Pharmaceutics) Wednesday March 31st 2010 0 comments, related, 2 Up Votes 0 comments, related, 1 Up Vote 0 comments, related, 2 Up Votes View: prev | next

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