1) New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration (Journal of Medicinal Chemistry) Tuesday March 9th 2010 2) Radiosynthesis and Bioimaging of the Tuberculosis Chemotherapeutics Isoniazid, Rifampicin and Pyrazinamide in Baboons (Journal of Medicinal Chemistry) Tuesday March 9th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 3) Erratum: Corrections to Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization (Journal of Medicinal Chemistry) Saturday March 6th 2010 4) Discovery, Biological Evaluation, and Structure−Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors (Journal of Medicinal Chemistry) Saturday March 6th 2010 5) Conformational Refinement of Hydroxamate-Based Histone Deacetylase Inhibitors and Exploration of 3-Piperidin-3-ylindole Analogues of Dacinostat (LAQ824) (Journal of Medicinal Chemistry) Saturday March 6th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 6) 2009 Reviewers (Journal of Medicinal Chemistry) Saturday March 6th 2010 7) Sulfonamide Linked Neoglycoconjugates−A New Class of Inhibitors for Cancer-Associated Carbonic Anhydrases (Journal of Medicinal Chemistry) Friday March 5th 2010 8) Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group (Journal of Medicinal Chemistry) Wednesday March 3rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 9) In Vitro and In Vivo Photocytotoxicity of Boron Dipyrromethene Derivatives for Photodynamic Therapy (Journal of Medicinal Chemistry) Wednesday March 3rd 2010 10) Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5) (Journal of Medicinal Chemistry) Wednesday March 3rd 2010 11) Book Review of Comprehensive Organic Name Reactions and Reagents (Journal of Medicinal Chemistry) Wednesday March 3rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 12) Structure−Activity Relationship of (N)-Methanocarba Phosphonate Analogues of 5′-AMP as Cardioprotective Agents Acting Through a Cardiac P2X Receptor (Journal of Medicinal Chemistry) Tuesday March 2nd 2010 13) Synthesis and QSAR of Quinazoline Sulfonamides As Highly Potent Human Histamine H4 Receptor Inverse Agonists (Journal of Medicinal Chemistry) Tuesday March 2nd 2010 14) Fragment-Based Deconstruction of Bcl-xL Inhibitors (Journal of Medicinal Chemistry) Tuesday March 2nd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 15) Discovery of a Biaryl Cyclohexene Carboxylic Acid (MK-6892): A Potent and Selective High Affinity Niacin Receptor Full Agonist with Reduced Flushing Profiles in Animals as a Preclinical Candidate (Journal of Medicinal Chemistry) Thursday February 25th 2010 16) Fluorescent Epigenetic Small Molecule Induces Expression of the Tumor Suppressor Ras-Association Domain Family 1A and Inhibits Human Prostate Xenograft (Journal of Medicinal Chemistry) Thursday February 25th 2010 17) Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds (Journal of Medicinal Chemistry) Thursday February 25th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 18) Dopamine Receptor Ligands. Part 18:(1) Modification of the Structural Skeleton of Indolobenzazecine-Type Dopamine Receptor Antagonists (Journal of Medicinal Chemistry) Wednesday February 24th 2010 19) Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1 (Journal of Medicinal Chemistry) Wednesday February 24th 2010 20) Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bacteria (Journal of Medicinal Chemistry) Wednesday February 24th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 21) Prediction and Evaluation of Protein Farnesyltransferase Inhibition by Commercial Drugs (Journal of Medicinal Chemistry) Wednesday February 24th 2010 22) Potent Arylsulfonamide Inhibitors of Tumor Necrosis Factor-α Converting Enzyme Able to Reduce Activated Leukocyte Cell Adhesion Molecule Shedding in Cancer Cell Models (Journal of Medicinal Chemistry) Wednesday February 24th 2010 23) Discovery of Dipeptides with High Affinity to the Specific Binding Site for Substance P1−7 (Journal of Medicinal Chemistry) Tuesday February 23rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 24) Discovery and SAR of Thiazolidine-2,4-dione Analogues as Insulin-like Growth Factor-1 Receptor (IGF-1R) Inhibitors via Hierarchical Virtual Screening (Journal of Medicinal Chemistry) Tuesday February 23rd 2010 25) Intramolecular Hydrogen Bonding in Medicinal Chemistry (Journal of Medicinal Chemistry) Monday February 22nd 2010 26) A Novel Insulin Secretagogue Based on a Dinucleoside Polyphosphate Scaffold(1) (Journal of Medicinal Chemistry) Monday February 22nd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 27) Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases Inhibitors (Journal of Medicinal Chemistry) Friday February 19th 2010 28) 1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Triple Reuptake Inhibitors (Journal of Medicinal Chemistry) Friday February 19th 2010 29) Development of Novel Adenosine Monophosphate-Activated Protein Kinase Activators (Journal of Medicinal Chemistry) Friday February 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 30) Identification of 2-Anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation (Journal of Medicinal Chemistry) Friday February 19th 2010 31) A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis (Journal of Medicinal Chemistry) Friday February 19th 2010 32) Noncovalent Tripeptidyl Benzyl- and Cyclohexyl-Amine Inhibitors of the Cysteine Protease Caspase-1 (Journal of Medicinal Chemistry) Friday February 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 33) N-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood−Brain Barrier Shuttles (Journal of Medicinal Chemistry) Friday February 19th 2010 34) Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) (Journal of Medicinal Chemistry) Friday February 19th 2010 35) Novel Diamidino-Substituted Derivatives of Phenyl Benzothiazolyl and Dibenzothiazolyl Furans and Thiophenes: Synthesis, Antiproliferative and DNA Binding Properties (Journal of Medicinal Chemistry) Friday February 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 36) Synthesis and Biological Activities of 2-Amino-1-arylidenamino Imidazoles as Orally Active Anticancer Agents (Journal of Medicinal Chemistry) Friday February 19th 2010 37) 5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT6 Receptor Antagonists (Journal of Medicinal Chemistry) Friday February 19th 2010 38) Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme−Ligand X-ray Studies (Journal of Medicinal Chemistry) Friday February 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 39) Synthesis and Characterization of Rhenium and Technetium-99m Labeled Insulin (Journal of Medicinal Chemistry) Friday February 19th 2010 40) Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor (Journal of Medicinal Chemistry) Thursday February 18th 2010 41) Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor (Journal of Medicinal Chemistry) Wednesday February 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 42) Piracetam Defines a New Binding Site for Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors (Journal of Medicinal Chemistry) Wednesday February 17th 2010 43) The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E2 Subtype 4 Receptor Antagonist† (Journal of Medicinal Chemistry) Wednesday February 17th 2010 44) Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Smoking Cessation (Journal of Medicinal Chemistry) Wednesday February 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 45) Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1 Receptors (Journal of Medicinal Chemistry) Wednesday February 17th 2010 46) Molecular Shape and Medicinal Chemistry: A Perspective (Journal of Medicinal Chemistry) Wednesday February 17th 2010 47) Synthesis, in Vitro and in Vivo Biological Evaluation, Docking Studies, and Structure−Activity Relationship (SAR) Discussion of Dipeptidyl Boronic Acid Proteasome Inhibitors Composed of β-Amino Acids (Journal of Medicinal Chemistry) Wednesday February 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 48) Structural Basis for Platelet Antiaggregation by Angiotensin II Type 1 Receptor Antagonist Losartan (DuP-753) via Glycoprotein VI (Journal of Medicinal Chemistry) Wednesday February 17th 2010 49) 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists (Journal of Medicinal Chemistry) Wednesday February 17th 2010 50) Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Brucella suis (Journal of Medicinal Chemistry) Wednesday February 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote View: prev | next

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