1) Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2,3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [13C2]-VC (Chemical Research in Toxicology) Tuesday August 31st 2010 2) In Vitro Studies of DNA Damage Caused by Tricyclic Antidepressants: A Role of Peroxidase in the Side Effects of the Drugs (Chemical Research in Toxicology) Tuesday August 31st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 3) Intramolecular Conversion of Pentaaquahydroperoxidochromium(III) Ion to Aqueous Chromium(V): Potential Source of Carcinogenic Forms of Chromium in Aerobic Organisms (Chemical Research in Toxicology) Saturday August 28th 2010 4) Effect of a Microemulsion System on Hapten-Peptide Reactivity Studies: Examples of Hydroxycitronellal and Citral, Fragrance Skin Sensitizers, with Glutathione (Chemical Research in Toxicology) Friday August 27th 2010 5) Potent Mutagenicity of 3-Methylindole Requires Pulmonary Cytochrome P450-Mediated Bioactivation: A Comparison to the Prototype Cigarette Smoke Mutagens B(a)P and NNK (Chemical Research in Toxicology) Friday August 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 6) Proliferation Inhibition, DNA Damage, and Cell-Cycle Arrest of Human Astrocytoma Cells after Acrylamide Exposure (Chemical Research in Toxicology) Wednesday August 25th 2010 7) Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell Growth (Chemical Research in Toxicology) Friday August 20th 2010 8) Glyphosate-Based Herbicides Produce Teratogenic Effects on Vertebrates by Impairing Retinoic Acid Signaling (Chemical Research in Toxicology) Tuesday August 10th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 9) Differential Cellular Responses to Protein Adducts of Naphthoquinone and Monocrotaline Pyrrole (Chemical Research in Toxicology) Tuesday August 10th 2010 10) Cytotoxicity of Cu(II) and Zn(II) 2,2′-Bipyridyl Complexes: Dependence of IC50 on Recovery Time (Chemical Research in Toxicology) Tuesday August 3rd 2010 11) Mechanistic Category Formation for the Prediction of Respiratory Sensitization (Chemical Research in Toxicology) Tuesday August 3rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 12) Characterization of Glutathione Conjugates of Duloxetine by Mass Spectrometry and Evaluation of in Silico Approaches to Rationalize the Site of Conjugation for Thiophene Containing Drugs (Chemical Research in Toxicology) Friday July 30th 2010 13) Determination of Cisplatin 1,2-Intrastrand Guanine−Guanine DNA Adducts in Human Leukocytes by High-Performance Liquid Chromatography Coupled to Inductively Coupled Plasma Mass Spectrometry (Chemical Research in Toxicology) Thursday July 29th 2010 14) Detection of Lipid Peroxidation-Induced DNA Adducts Caused by 4-Oxo-2(E)-nonenal and 4-Oxo-2(E)-hexenal in Human Autopsy Tissues (Chemical Research in Toxicology) Saturday July 24th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 15) Teratogenic Effects of Blue Cohosh (Caulophyllum thalictroides) in Japanese Medaka (Oryzias latipes) Are Probably Mediated through GATA2/EDN1 Signaling Pathway (Chemical Research in Toxicology) Saturday July 24th 2010 16) The Inhaled Glucocorticoid Fluticasone Propionate Efficiently Inactivates Cytochrome P450 3A5, a Predominant Lung P450 Enzyme (Chemical Research in Toxicology) Saturday July 24th 2010 17) Unexpected Toxicity of Monolayer Protected Gold Clusters Eliminated by PEG-Thiol Place Exchange Reactions (Chemical Research in Toxicology) Saturday July 24th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 18) Estrogenic Activity of Anthraquinone Derivatives: In Vitro and In Silico Studies (Chemical Research in Toxicology) Saturday July 24th 2010 19) Malondialdehyde−Deoxyguanosine Adduct Formation in Workers of Pathology Wards: The Role of Air Formaldehyde Exposure (Chemical Research in Toxicology) Tuesday July 20th 2010 20) In This Issue (Chemical Research in Toxicology) Tuesday July 20th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 21) Spotlight (Chemical Research in Toxicology) Tuesday July 20th 2010 22) Sensitization of Non-small Cell Lung Cancer Cells to Cisplatin by Naturally Occurring Isothiocyanates (Chemical Research in Toxicology) Friday July 16th 2010 23) Role of Human Glutathione S-Transferases in the Inactivation of Reactive Metabolites of Clozapine (Chemical Research in Toxicology) Friday July 16th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 24) Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity (Chemical Research in Toxicology) Thursday July 15th 2010 25) Cloning, Expression and Functional Characterization of Cytochrome P450 3A37 from Turkey Liver with High Aflatoxin B1 Epoxidation Activity† (Chemical Research in Toxicology) Thursday July 15th 2010 26) Erratum: Proteomic Analysis of DNA−Protein Cross-Linking by Antitumor Nitrogen Mustards (Chemical Research in Toxicology) Friday July 9th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 27) Cross-Linking of Dithiols by Mitomycin C (Chemical Research in Toxicology) Thursday July 8th 2010 28) Exposure of a Monoclonal Antibody, IgG1, to UV-Light Leads to Protein Dithiohemiacetal and Thioether Cross-Links: A Role for Thiyl Radicals? (Chemical Research in Toxicology) Wednesday July 7th 2010 29) Evaluation of DNA Adducts, DNA and RNA Oxidative Lesions, and 3-Hydroxybenzo(a)pyrene as Biomarkers of DNA Damage in Lung Following Intravenous Injection of the Parent Compound in Rats (Chemical Research in Toxicology) Saturday July 3rd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 30) Ability of Hypochlorous Acid and N-Chloramines to Chlorinate DNA and Its Constituents (Chemical Research in Toxicology) Friday July 2nd 2010 31) Probing Platinum−Adenine-N3 Adduct Formation with DNA Minor-Groove Binding Agents (Chemical Research in Toxicology) Tuesday June 29th 2010 32) Comparison of the in Vitro Replication of the 7-(2-Oxoheptyl)-1,N2-etheno-2′-deoxyguanosine and 1,N2-Etheno-2′-deoxyguanosine Lesions by Sulfolobus solfataricus P2 DNA Polymerase IV (Dpo4) (Chemical Research in Toxicology) Monday June 28th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 33) Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes (Chemical Research in Toxicology) Saturday June 26th 2010 34) In This Issue (Chemical Research in Toxicology) Monday June 21st 2010 35) Spotlight (Chemical Research in Toxicology) Monday June 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 36) Methyl Antcinate A from Antrodia camphorata Induces Apoptosis in Human Liver Cancer Cells through Oxidant-Mediated Cofilin- and Bax-Triggered Mitochondrial Pathway (Chemical Research in Toxicology) Friday June 18th 2010 37) Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel† (Chemical Research in Toxicology) Friday June 18th 2010 38) Effect of Clozapine on Neutrophil Kinetics in Rabbits (Chemical Research in Toxicology) Friday June 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 39) Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity (Chemical Research in Toxicology) Thursday June 17th 2010 40) Ultrasensitive Simultaneous Quantification of 1,N2-Etheno-2′-deoxyguanosine and 1,N2-Propano-2′-deoxyguanosine in DNA by an Online Liquid Chromatography−Electrospray Tandem Mass Spectrometry Assay (Chemical Research in Toxicology) Wednesday June 16th 2010 41) Alkylating Potential of Oxetanes (Chemical Research in Toxicology) Wednesday June 16th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 42) Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone (Chemical Research in Toxicology) Tuesday June 15th 2010 43) Lead Detoxification Activity and ADMET Hepatotoxicity of N-(α-l-Arabino-furanos-1-yl)-l-cysteine (Chemical Research in Toxicology) Tuesday June 15th 2010 44) Unexpected Hormonal Activity of a Catechol Equine Estrogen Metabolite Reveals Reversible Glutathione Conjugation (Chemical Research in Toxicology) Saturday June 12th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 45) DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1 (Chemical Research in Toxicology) Friday June 11th 2010 46) Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury (Chemical Research in Toxicology) Friday June 4th 2010 47) Involvement of Various Molecular Events in Cellular Injury Induced by Smokeless Tobacco (Chemical Research in Toxicology) Friday June 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 48) Application of Genomics for Identification of Systemic Toxicity Triggers Associated With VEGF-R Inhibitors (Chemical Research in Toxicology) Friday June 4th 2010 49) Redox Cycling of Catechol Estrogens Generating Apurinic/Apyrimidinic Sites and 8-oxo-Deoxyguanosine via Reactive Oxygen Species Differentiates Equine and Human Estrogens (Chemical Research in Toxicology) Saturday May 29th 2010 50) Antimony Impairs Nucleotide Excision Repair: XPA and XPE as Potential Molecular Targets (Chemical Research in Toxicology) Saturday May 29th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 51) Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis (Chemical Research in Toxicology) Friday May 28th 2010 52) Chemical Demethylation of Methylmercury by Selenoamino Acids (Chemical Research in Toxicology) Thursday May 27th 2010 53) 1,4-Benzoquinone (PBQ) Induced Toxicity in Lung Epithelial Cells Is Mediated by the Disruption of the Microtubule Network and Activation of Caspase-3 (Chemical Research in Toxicology) Thursday May 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 54) Drug Metabolite-Specific Lymphocyte Responses in Sulfamethoxazole Allergic Patients with Cystic Fibrosis (Chemical Research in Toxicology) Friday May 21st 2010 55) In This Issue (Chemical Research in Toxicology) Monday May 17th 2010 56) Spotlight (Chemical Research in Toxicology) Monday May 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 57) Biological and Molecular Mechanisms of Sulfur Mustard Analogue-Induced Toxicity in JB6 and HaCaT Cells: Possible Role of Ataxia Telangiectasia-Mutated/Ataxia Telangiectasia-Rad3-Related Cell Cycle Checkpoint Pathway (Chemical Research in Toxicology) Saturday May 15th 2010 58) Nitrogen Dioxide-Dependent Oxidation of Uric Acid in the Human Oral Cavity under Acidic Conditions: Implications for Its Occurrence in Acidic Dental Plaque (Chemical Research in Toxicology) Friday May 7th 2010 59) Human Liver Microsomal Cytochrome P450 3A Enzymes Involved in Thalidomide 5-Hydroxylation and Formation of a Glutathione Conjugate (Chemical Research in Toxicology) Friday May 7th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 60) Products of the Direct Reaction of the Diazonium Ion of a Metabolite of the Carcinogen N-Nitrosomorpholine with Purines of Nucleosides and DNA (Chemical Research in Toxicology) Thursday May 6th 2010 61) Identification of Carcinogen DNA Adducts in Human Saliva by Linear Quadrupole Ion Trap/Multistage Tandem Mass Spectrometry (Chemical Research in Toxicology) Thursday May 6th 2010 62) Detection of 7-(2′-Carboxyethyl)guanine but Not 7-Carboxymethylguanine in Human Liver DNA (Chemical Research in Toxicology) Tuesday May 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 63) Hydroxywarfarin Metabolites Potently Inhibit CYP2C9 Metabolism of S-Warfarin (Chemical Research in Toxicology) Friday April 30th 2010 64) Development of a Selective Modulator of Aryl Hydrocarbon (Ah) Receptor Activity that Exhibits Anti-Inflammatory Properties (Chemical Research in Toxicology) Thursday April 29th 2010 65) Caenorhabditis elegans Bicarbonate Transporter ABTS-1 Is Involved in Arsenite Toxicity and Cholinergic Signaling (Chemical Research in Toxicology) Thursday April 29th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 66) Ex Vivo Oxidation in Tissue and Plasma Assays of Hydroxyoctadecadienoates: Z,E/E,E Stereoisomer Ratios (Chemical Research in Toxicology) Thursday April 29th 2010 67) Evaluating Cytotoxicity and Cellular Uptake from the Presence of Variously Processed TiO2 Nanostructured Morphologies (Chemical Research in Toxicology) Saturday April 24th 2010 68) Applying Tobacco Carcinogen and Toxicant Biomarkers in Product Regulation and Cancer Prevention (Chemical Research in Toxicology) Saturday April 24th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 69) QSAR Modeling and Prediction of the Endocrine-Disrupting Potencies of Brominated Flame Retardants (Chemical Research in Toxicology) Saturday April 24th 2010 70) Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine by Oxyl Radicals Produced by Photolysis of Azo Compounds (Chemical Research in Toxicology) Saturday April 24th 2010 71) Nimesulide-Induced Electrophile Stress Activates Nrf2 in Human Hepatocytes and Mice but Is Not Sufficient to Induce Hepatotoxicity in Nrf2-Deficient Mice (Chemical Research in Toxicology) Wednesday April 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 72) Interfacing Carbon Nanotubes with Living Mammalian Cells and Cytotoxicity Issues (Chemical Research in Toxicology) Tuesday April 20th 2010 73) Rapid and Simple Kinetics Screening Assay for Electrophilic Dermal Sensitizers Using Nitrobenzenethiol (Chemical Research in Toxicology) Tuesday April 20th 2010 74) Cytochrome P450 2A5 Constitutive Expression and Induction by Heavy Metals Is Dependent on Redox-Sensitive Transcription Factor Nrf2 in Liver (Chemical Research in Toxicology) Tuesday April 20th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 75) In This Issue (Chemical Research in Toxicology) Monday April 19th 2010 76) Spotlight (Chemical Research in Toxicology) Monday April 19th 2010 77) Amino Acid Adduct Formation by the Nevirapine Metabolite, 12-Hydroxynevirapine—A Possible Factor in Nevirapine Toxicity (Chemical Research in Toxicology) Friday April 16th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 78) Predicting the Rate and Extent of Fragrance Chemical Absorption into and through the Skin (Chemical Research in Toxicology) Friday April 16th 2010 79) The C8-2′-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[1,2-d]naphthalene, a Carbocyclic Analogue of the Potent Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline, Is a Block to Replication in Vitro (Chemical Research in Toxicology) Friday April 9th 2010 80) Analysis of Phenanthrene and Benzo[a]pyrene Tetraol Enantiomers in Human Urine: Relevance to the Bay Region Diol Epoxide Hypothesis of Benzo[a]pyrene Carcinogenesis and to Biomarker Studies (Chemical Research in Toxicology) Wednesday April 7th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 81) Formation of a Quinoneimine Intermediate of 4-Fluoro-N-methylaniline by FMO1: Carbon Oxidation Plus Defluorination (Chemical Research in Toxicology) Wednesday April 7th 2010 82) Characterization of Aziridinylbenzoquinone DNA Cross-Links by Liquid Chromatography−Infrared Multiphoton Dissociation−Mass Spectrometry (Chemical Research in Toxicology) Wednesday April 7th 2010 83) Phospholipidosis as a Function of Basicity, Lipophilicity, and Volume of Distribution of Compounds (Chemical Research in Toxicology) Friday April 2nd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 84) Formation of a Vitamin C Conjugate of Acrolein and Its Paraoxonase-Mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal (Chemical Research in Toxicology) Wednesday March 31st 2010 85) Selective Targeting of Selenocysteine in Thioredoxin Reductase by the Half Mustard 2-Chloroethyl Ethyl Sulfide in Lung Epithelial Cells (Chemical Research in Toxicology) Tuesday March 30th 2010 86) Investigation of Bioactivation of Ticlopidine Using Linear Ion Trap/Orbitrap Mass Spectrometry and an Improved Mass Defect Filtering Technique (Chemical Research in Toxicology) Friday March 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 2 Up Votes 0 comments, related, 1 Up Vote 87) Polychlorinated Biphenyls PCB 52, PCB 180, and PCB 138 Impair the Glutamate−Nitric Oxide−cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms (Chemical Research in Toxicology) Friday March 19th 2010 88) Direct Trapping of Acrylamide as a Key Mechanism for Niacin’s Inhibitory Activity in Carcinogenic Acrylamide Formation (Chemical Research in Toxicology) Thursday March 18th 2010 89) Recommendations for Standardized Description of and Nomenclature Concerning Oxidatively Damaged Nucleobases in DNA (Chemical Research in Toxicology) Thursday March 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 90) Xenobiotic Metabolism: A View through the Metabolometer (Chemical Research in Toxicology) Thursday March 18th 2010 91) Excision of a Lyase-Resistant Oxidized Abasic Lesion from DNA (Chemical Research in Toxicology) Wednesday March 17th 2010 92) Column Switching HPLC-ESI+-MS/MS Methods for Quantitative Analysis of Exocyclic dA Adducts in the DNA of Laboratory Animals Exposed to 1,3-Butadiene (Chemical Research in Toxicology) Tuesday March 16th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 93) In this Issue (Chemical Research in Toxicology) Monday March 15th 2010 94) Spotlight (Chemical Research in Toxicology) Monday March 15th 2010 95) Effect of Green Tea Catechins and Hydrolyzable Tannins on Benzo[a]pyrene-Induced DNA Adducts and Structure−Activity Relationship (Chemical Research in Toxicology) Thursday March 11th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 96) Nitric Oxide, Oxygen, and Superoxide Formation and Consumption in Macrophages and Colonic Epithelial Cells (Chemical Research in Toxicology) Friday March 5th 2010 97) Investigating the Mechanisms of Aromatic Amine-Induced Protein Free Radical Formation by Quantitative Structure−Activity Relationships: Implications for Drug-Induced Agranulocytosis (Chemical Research in Toxicology) Wednesday March 3rd 2010 98) Erratum: Analysis of 23 Polycyclic Aromatic Hydrocarbons in Smokeless Tobacco by Gas Chromatography−Mass Spectrometry (Chemical Research in Toxicology) Tuesday March 2nd 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 2 Up Votes View: prev | next

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