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1) Regulation of Human Carbonyl Reductase 3 (CBR3 SDR21C2) Expression by Nrf2 in Cultured Cancer Cells (Biochemistry) Wednesday September 8th 2010 2) Positions 94−98 of the Lactose Repressor N-Subdomain Monomer−Monomer Interface Are Critical for Allosteric Communication (Biochemistry) Wednesday September 8th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 3) Steady-State Kinetic and Inhibition Studies of the Mammalian Target of Rapamycin (mTOR) Kinase Domain and mTOR Complexes (Biochemistry) Wednesday September 8th 2010 4) Topology of Transmembrane Channel-like Gene 1 Protein (Biochemistry) Wednesday September 8th 2010 5) Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis (Biochemistry) Wednesday September 8th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 6) Structural and Functional Characterization of the Recombinant Human Mitochondrial Trifunctional Protein (Biochemistry) Wednesday September 8th 2010 7) Defining a Stem Length-Dependent Binding Mechanism for the Cocaine-Binding Aptamer. A Combined NMR and Calorimetry Study (Biochemistry) Tuesday September 7th 2010 8) Characterization of the N-Acetyl-α-d-glucosaminyl l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis in Bacillus anthracis, (Biochemistry) Tuesday September 7th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 9) Physical Trapping of HIV-1 Synaptic Complex by Different Structural Classes of Integrase Strand Transfer Inhibitors (Biochemistry) Tuesday September 7th 2010 10) Binding of the Dimeric Deinococcus radiodurans Single-Stranded DNA Binding Protein to Single-Stranded DNA (Biochemistry) Tuesday September 7th 2010 11) DsrJ, an Essential Part of the DsrMKJOP Transmembrane Complex in the Purple Sulfur Bacterium Allochromatium vinosum, Is an Unusual Triheme Cytochrome c (Biochemistry) Tuesday September 7th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 12) Generation of a Manganese Specific Restriction Endonuclease with Nicking Activity (Biochemistry) Saturday September 4th 2010 13) Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain (Biochemistry) Saturday September 4th 2010 14) Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers (Biochemistry) Saturday September 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 15) Oncogenic CARD11 Mutations Induce Hyperactive Signaling by Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain (Biochemistry) Saturday September 4th 2010 16) Escherichia coli Mutants That Synthesize Dephosphorylated Lipid A Molecules (Biochemistry) Saturday September 4th 2010 17) Competitive and Noncompetitive Binding of eIF4B, eIF4A, and the Poly(A) Binding Protein to Wheat Translation Initiation Factor eIFiso4G (Biochemistry) Saturday September 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 18) Activation and Specificity of Human Caspase-10 (Biochemistry) Saturday September 4th 2010 19) Mutation of the ATP Cassette Binding Transporter A1 (ABCA1) C-Terminus Disrupts HIV-1 Nef Binding but Does Not Block the Nef Enhancement of ABCA1 Protein Degradation (Biochemistry) Saturday September 4th 2010 20) In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1 (Biochemistry) Saturday September 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 21) STPR, a 23-Amino Acid Tandem Repeat Domain, Found in the Human Function-Unknown Protein ZNF821 (Biochemistry) Saturday September 4th 2010 22) Correlation of Active Site Metal Content in Human Diamine Oxidase with Trihydroxyphenylalanine Quinone Cofactor Biogenesis, (Biochemistry) Saturday September 4th 2010 23) Comparative Kinetics of Cofactor Association and Dissociation for the Human and Trypanosomal S-Adenosylhomocysteine Hydrolases. 3. Role of Lysyl and Tyrosyl Residues of the C-Terminal Extension (Biochemistry) Saturday September 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 24) A Novel Disulfide Pattern in Laminin-Type Epidermal Growth Factor-like (LE) Modules of Laminin β1 and γ1 Chains (Biochemistry) Saturday September 4th 2010 25) Selective Targeting of G-Quadruplex Using Furan-Based Cyclic Homooligopeptides: Effect on c-MYC Expression (Biochemistry) Saturday September 4th 2010 26) The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression (Biochemistry) Saturday September 4th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 27) Structure and RNA Interactions of the Plant MicroRNA Processing-Associated Protein HYL1 (Biochemistry) Saturday September 4th 2010 28) Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the Bacillus subtilis RNase P RNA Specificity Domain (Biochemistry) Tuesday August 31st 2010 29) Backbone Amide Dynamics Studies of Apo-L75F-TrpR, a Temperature-Sensitive Mutant of the Tryptophan Repressor Protein (TrpR): Comparison with the 15N NMR Relaxation Profiles of Wild-Type and A77V Mutant Apo-TrpR Repressors (Biochemistry) Tuesday August 31st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 30) Kinetic Analysis Reveals Differences in the Binding Mechanism of Calmodulin and Calmodulin-like Protein to the IQ Motifs of Myosin-10 (Biochemistry) Tuesday August 31st 2010 31) Direct Measurement of Mercury(II) Removal from Organomercurial Lyase (MerB) by Tryptophan Fluorescence: NmerA Domain of Coevolved γ-Proteobacterial Mercuric Ion Reductase (MerA) Is More Efficient Than MerA Catalytic Core or Glutathione (Biochemistry) Tuesday August 31st 2010 32) Crystal Structures of Covalent Complexes of β-Lactam Antibiotics with Escherichia coli Penicillin-Binding Protein 5: Toward an Understanding of Antibiotic Specificity (Biochemistry) Tuesday August 31st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 33) The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity (Biochemistry) Tuesday August 31st 2010 34) NMR Studies of Translocation of the Zif268 Protein between Its Target DNA Sites (Biochemistry) Tuesday August 31st 2010 35) Direct Evidence of Conformational Heterogeneity in Human Pancreatic Glucokinase from High-Resolution Nuclear Magnetic Resonance (Biochemistry) Tuesday August 31st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 36) Role of the Highly Conserved Middle Region of Prion Protein (PrP) in PrP−Lipid Interaction (Biochemistry) Tuesday August 31st 2010 37) The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis (Biochemistry) Friday August 27th 2010 38) Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes (Biochemistry) Friday August 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 39) Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein (Biochemistry) Friday August 27th 2010 40) A Kinetic and Isotope Effect Investigation of the Urease-Catalyzed Hydrolysis of Hydroxyurea (Biochemistry) Friday August 27th 2010 41) Brønsted Analysis and Rate-Limiting Steps for the T5 Flap Endonuclease Catalyzed Hydrolysis of Exonucleolytic Substrates (Biochemistry) Friday August 27th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 42) Structural Analysis of the Smad2−MAN1 Interaction That Regulates Transforming Growth Factor-β Signaling at the Inner Nuclear Membrane (Biochemistry) Friday August 27th 2010 43) Double Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate (Biochemistry) Thursday August 26th 2010 44) Zwitterion Modulation of O2-Evolving Activity of Cyanobacterial Photosystem II (Biochemistry) Thursday August 26th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 45) Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in Neisseria gonorrhoeae: Role of Epistatic Mutations (Biochemistry) Thursday August 26th 2010 46) Kinetic Analysis of 14-3-3-Inhibited Arabidopsis thaliana Nitrate Reductase (Biochemistry) Wednesday August 25th 2010 47) Distinct Extracytoplasmic Siderophore Binding Proteins Recognize Ferrioxamines and Ferricoelichelin in Streptomyces coelicolor A3(2) (Biochemistry) Wednesday August 25th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 48) Multiconformation Continuum Electrostatics Analysis of the Effects of a Buried Asp Introduced near Heme a in Rhodobacter sphaeroides Cytochrome c Oxidase (Biochemistry) Wednesday August 25th 2010 49) Characterization of Glycosyltransferase DesVII and Its Auxiliary Partner Protein DesVIII in the Methymycin/Pikromycin Biosynthetic Pathway (Biochemistry) Wednesday August 25th 2010 50) Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase (Biochemistry) Wednesday August 25th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 51) Structural Determinants for the Stereoselective Hydrolysis of Chiral Substrates by Phosphotriesterase (Biochemistry) Wednesday August 25th 2010 52) Converting GLX2-1 into an Active Glyoxalase II (Biochemistry) Wednesday August 25th 2010 53) Binding of the Gene Repressor BlaI to the bla Operon in Methicillin-Resistant Staphylococcus aureus (Biochemistry) Wednesday August 25th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 54) Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA (Biochemistry) Tuesday August 24th 2010 55) Evidence of Adaptability in Metal Coordination Geometry and Active-Site Loop Conformation among B1 Metallo-β-lactamases (Biochemistry) Tuesday August 24th 2010 56) Redox Reactions of the α-Synuclein−Cu2+ Complex and Their Effects on Neuronal Cell Viability (Biochemistry) Tuesday August 24th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 57) Selection for Nonamyloidogenic Mutants of Islet Amyloid Polypeptide (IAPP) Identifies an Extended Region for Amyloidogenicity (Biochemistry) Saturday August 21st 2010 58) TNF Receptor-1 (TNF-R1) Ubiquitous Scaffolding and Signaling Protein Interacts with TNF-R1 and TRAF2 via an N-Terminal Docking Interface (Biochemistry) Saturday August 21st 2010 59) Cell-Selective Lysis by Novel Analogues of Melittin against Human Red Blood Cells and Escherichia coli (Biochemistry) Saturday August 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 60) Targeting of an Interrupted Polypurine:Polypyrimidine Sequence in Mammalian Cells by a Triplex-Forming Oligonucleotide Containing a Novel Base Analogue (Biochemistry) Saturday August 21st 2010 61) Modeling of the Endosomolytic Activity of HA2-TAT Peptides with Red Blood Cells and Ghosts (Biochemistry) Saturday August 21st 2010 62) Off-Pathway Status for the Alkali Molten Globule of Horse Ferricytochrome c (Biochemistry) Saturday August 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 63) The Off-Pathway Status of the Alkali Molten Globule Is Unrelated to Heme Misligation and Trans-pH Effects: Experiments with Ferrocytochrome c (Biochemistry) Saturday August 21st 2010 64) Nonspecific DNA Binding and Coordination of the First Two Steps of Base Excision Repair (Biochemistry) Saturday August 21st 2010 65) Structural Basis of Low-Affinity Nickel Binding to the Nickel-Responsive Transcription Factor NikR from Escherichia coli (Biochemistry) Saturday August 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 66) Searching for the nik Operon: How a Ligand-Responsive Transcription Factor Hunts for Its DNA Binding Site (Biochemistry) Saturday August 21st 2010 67) Structural Basis for the Specificity of the GAE Domain of yGGA2 for Its Accessory Proteins Ent3 and Ent5 (Biochemistry) Saturday August 21st 2010 68) Visualizing the Metal-Binding Versatility of Copper Trafficking Sites (Biochemistry) Saturday August 21st 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 69) Mechanism of Potentiation of a Dysfunctional Epilepsy-Linked Mutated GABAA Receptor by a Neurosteroid (3α, 21-Dihydroxy-5α-pregnan-20-one): Transient Kinetic Investigations (Biochemistry) Saturday August 21st 2010 70) Structural and Functional Characterization of the Ga-Substituted Ferredoxin from Synechocystis sp. PCC6803, a Mimic of the Native Protein (Biochemistry) Friday August 20th 2010 71) Substituent Effects on the Reaction of β-Benzoylalanines with Pseudomonas fluorescens Kynureninase (Biochemistry) Friday August 20th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 72) 3′-Sulfo-Lex Is Important for Regulation of Integrin Subunit αV (Biochemistry) Friday August 20th 2010 73) Structural and Functional Studies of WlbA: A Dehydrogenase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-mannuronic Acid (Biochemistry) Friday August 20th 2010 74) Tyrosine 112 Is Essential for Organic Cation Transport by the Plasma Membrane Monoamine Transporter (Biochemistry) Thursday August 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 75) Polyhistidine Peptide Inhibitor of the Aβ Calcium Channel Potently Blocks the Aβ-Induced Calcium Response in Cells. Theoretical Modeling Suggests a Cooperative Binding Process (Biochemistry) Thursday August 19th 2010 76) Oxidation Reactions Performed by Soluble Methane Monooxygenase Hydroxylase Intermediates Hperoxo and Q Proceed by Distinct Mechanisms (Biochemistry) Thursday August 19th 2010 77) Recombinant Expression, in Vitro Refolding, and Biophysical Characterization of the Human Glucagon-like Peptide-1 Receptor (Biochemistry) Thursday August 19th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 78) The Diheme Cytochrome c4 from Vibrio cholerae Is a Natural Electron Donor to the Respiratory cbb3 Oxygen Reductase (Biochemistry) Wednesday August 18th 2010 79) Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases (Biochemistry) Wednesday August 18th 2010 80) Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1) (Biochemistry) Wednesday August 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 81) Creation and Biophysical Characterization of a High-Affinity, Monomeric EGF Receptor Ectodomain Using Fluorescent Proteins (Biochemistry) Wednesday August 18th 2010 82) Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus marinus (Biochemistry) Wednesday August 18th 2010 83) Engineering the Enolase Magnesium II Binding Site: Implications for Its Evolution (Biochemistry) Wednesday August 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 84) Identification of a Regulatory Segment of Poly(ADP-ribose) Glycohydrolase (Biochemistry) Wednesday August 18th 2010 85) Noncovalent Interaction of α2-Antiplasmin with Fibrin(ogen): Localization of α2-Antiplasmin-Binding Sites (Biochemistry) Wednesday August 18th 2010 86) Structure of CyanoP at 2.8 Å: Implications for the Evolution and Function of the PsbP Subunit of Photosystem II (Biochemistry) Wednesday August 18th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 87) Effects of Mutations in Aedes aegypti Sterol Carrier Protein-2 on the Biological Function of the Protein (Biochemistry) Wednesday August 18th 2010 88) Stoichiometry and Topology of the Complex of the Endogenous ATP Synthase Inhibitor Protein IF1 with Calmodulin (Biochemistry) Tuesday August 17th 2010 89) Lipid Bilayer-Assisted Release of an Enediyne Antibiotic from Neocarzinostatin Chromoprotein (Biochemistry) Tuesday August 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 90) Salt-Induced Modulation of the Pathway of Amyloid Fibril Formation by the Mouse Prion Protein (Biochemistry) Tuesday August 17th 2010 91) Leucine-Rich Pentatricopeptide-Repeat Containing Protein Regulates Mitochondrial Transcription (Biochemistry) Tuesday August 17th 2010 92) Cysteine sulfenic Acid as an Intermediate in Disulfide Bond Formation and Nonenzymatic Protein Folding (Biochemistry) Tuesday August 17th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 93) Mechanistic Diversity of Red Fluorescence Acquisition by GFP-like Proteins (Biochemistry) Tuesday August 17th 2010 94) Bovine Serum Albumin-Catalyzed Deprotonation of [1-13C]Glycolaldehyde: Protein Reactivity toward Deprotonation of the α-Hydroxy α-Carbonyl Carbon (Biochemistry) Tuesday August 17th 2010 95) Identification of Catalytic Residues and Mechanistic Analysis of Family GH82 ι-Carrageenases (Biochemistry) Saturday August 14th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 96) Structural Insight into Methyl-Coenzyme M Reductase Chemistry Using Coenzyme B Analogues (Biochemistry) Saturday August 14th 2010 97) S-Adenosyl-l-methionine Regulation of the Cardiac Ryanodine Receptor Involves Multiple Mechanisms (Biochemistry) Saturday August 14th 2010 98) Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus (Biochemistry) Saturday August 14th 2010 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote 0 comments, related, 1 Up Vote View: prev | next

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